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Sedoykin A.G.

Russian University of Medicine, Moscow, Russia

Kiselnikova L.P.

Russian University of Medicine, Moscow, Russia

Andreeva V.V.

Russian University of Medicine, Moscow, Russia

Clinical study of the anti-carious efficacy of nano-hydroxyapatite toothpaste in preschool children

Authors:

Sedoykin A.G., Kiselnikova L.P., Andreeva V.V.

More about the authors

Journal: Russian Journal of Stomatology. 2026;19(1): 52‑57

Read: 554 times


To cite this article:

Sedoykin AG, Kiselnikova LP, Andreeva VV. Clinical study of the anti-carious efficacy of nano-hydroxyapatite toothpaste in preschool children. Russian Journal of Stomatology. 2026;19(1):52‑57. (In Russ.)
https://doi.org/10.17116/rosstomat20261901152

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References:

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  2. Aliyyu WC, Riva FA, Anabel SMP et al. Nano-Hydroxyapatite toothpaste of rice field snail shell combined with basil leaf extract as a remineralizing and antibacterial agent to prevent dental caries // J Clin Exp Dent. 2024 Nov 1;16(11):e1323-e1331. doi: 10.4317/jced.62073.
  3. Unterbrink P, Schulze ZWE, Meyer F et al. Prevention of dental caries: a review on the improvements of toothpaste formulations from 1900 to 2023 // Dent J (Basel) 2024;12(3):64. doi: 10.3390/dj12030064.
  4. https://doi.org/10.33925/1683-3031-2024-723 
  5. Schlagenhauf U et al. Impact of a non-fluoridated microcrystalline hydroxyapatite dentifrice on enamel caries progression in highly caries-susceptible orthodontic patients: a randomized, controlled 6-month trial // J. Invest. Clin. Dent. 10, e12399 (2019).
  6. Paszynska E, Pawinska M, Gawriolek M et al. Impact of a toothpaste with microcrystalline hydroxyapatite on the occurrence of early childhood caries: a 1-year randomized clinical trial // Sci Rep. 2021 Jan 29;11(1):265 
  7. Limeback H, Enax J, Meyer F. Biomimetic hydroxyapatite and caries prevention: a systematic review and meta-analysis // Can J Dent Hyg. 2021 Oct 1;55(3):148-159. PMID: 34925515; PMCID: PMC8641555.
  8. Andrea B, Carolina M, Gallo S et al. Biomimetic Action of Zinc Hydroxyapatite on Remineralization of Enamel and Dentin: A Review // Biomimetics (Basel). 2023 Feb 8;8(1):71. doi: 10.3390/biomimetics8010071.
  9. Wierichs RJ, Wolf TG, Campus G, Carvalho TS. Efficacy of nano-hydroxyapatite on caries prevention-a systematic review and meta-analysis // Clin Oral Investig. 2022 Apr;26(4):3373-3381. doi: 10.1007/s00784-022-04390-4. 
  10. Sudradjat H, Meyer F, Loza K et al. In Vivo Effects of a Hydroxyapatite-Based Oral Care Gel on the Calcium and Phosphorus Levels of Dental Plaque // Eur J Dent. 2020 Mar;14(2):206-211. doi: 10.1055/s-0040-1708456. Epub 2020 Apr 13. PMID: 32283562; PMCID: PMC7274817.
  11. Hannig C, Basche S, Burghardt T et al. Influence of a mouthwash containing hydroxyapatite microclusters on bacterial adherence in situ // Clin Oral Investig. 2013 Apr;17(3):805-14. doi: 10.1007/s00784-012-0781-6. Epub 2012 Jul 11. PMID: 22782257.
  12. Kensche A, Holder C, Basche S et al. Efficacy of a mouthrinse based on hydroxyapatite to reduce initial bacterial colonisation in situ. Arch Oral Biol. 2017 Aug;80:18-26. doi: 10.1016/j.archoralbio.2017.03.013. Epub 2017 Mar 23. PMID: 28364672.
  13. Signori C. CaCIA collaborative group; Uehara JLS., Romero VHD, Moro BLP et al. Comparison of two clinical approaches based on visual criteria for secondary caries assessments and treatment decisions in permanent posterior teeth // BMC Oral Health. 2022 Mar 18;22(1):77. doi: 10.1186/s12903-022-02112-6. 

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