Secondary follicles of the lymphoepithelial organs of the pharynx as the structural basis of the humoral component of adaptive immunity in immunotropic therapy

Ryazanskaya A.G.; Bykova V.P.; Yunusov A.S.

doi:https://doi.org/10.17116/rosrino202028031137

Ryazanskaya A.G.

Scientific and Clinical Center of Otorhinolaryngology

Bykova V.P.

Scientific and Clinical Center of Otorhinolaryngology

Yunusov A.S.

Scientific and Clinical Center of Otorhinolaryngology

Secondary follicles of the lymphoepithelial organs of the pharynx as the structural basis of the humoral component of adaptive immunity in immunotropic therapy

Authors:

Ryazanskaya A.G., Bykova V.P., Yunusov A.S.

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Journal: Russian Rhinology. 2020;28(3): 137‑144

DOI: 10.17116/rosrino202028031137

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To cite this article:

Ryazanskaya AG, Bykova VP, Yunusov AS. Secondary follicles of the lymphoepithelial organs of the pharynx as the structural basis of the humoral component of adaptive immunity in immunotropic therapy. Russian Rhinology. 2020;28(3):137‑144. (In Russ.)
https://doi.org/10.17116/rosrino202028031137

Подписка 2026 Российская ринология (Russian Rhinology)

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THE PURPOSE OF THE STUDY

Was to assess the morphofunctional state of the structures of the adaptive immune response of the pharyngeal tonsil based on the age-related dynamics of secondary follicles in adenoids under immunotropic therapy.

PATIENTS AND METHODS

Adenoids removed in 120 children aged 22 months to 16 years were studied histologically with selective use of immunohistochemistry methods.

THE RESULT OF THE STUDY

The use of immunomodulators creates an additional antigenic load, which is reflected in the hyperplasia of the secondary follicles and contributes to an increase in the volume of adenoid vegetation and adversely affects the function of nasal breathing.

Keywords:

secondary lymphoid follicles

germinal center

proliferative activity of B-lymphocytes

apoptosis

immunomodulation

Authors:

Ryazanskaya A.G.

Scientific and Clinical Center of Otorhinolaryngology

Bykova V.P.

Scientific and Clinical Center of Otorhinolaryngology

Yunusov A.S.

Scientific and Clinical Center of Otorhinolaryngology

Received:

23.03.2020

Accepted:

18.04.2020

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References:

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