Systemic analysis of anti-stress, normothymic, and hypnotic effects of passionflower extracts standardized for luteolin-7-glucoside

Gromova O.A.; Torshin I.Yu.

doi:https://doi.org/10.17116/profmed202528031112

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MATERIALS AND METHODS

Using topological and metric approaches, we analyzed 1141 publications on fundamental and clinical studies of PE in the PubMed database.

AIM

To analyze publications on fundamental and clinical studies of anti-stress, normothymic, and hypnotic effects of passionflower extracts.

RESULTS

Standardized passionflower extracts have a mild calming effect and no side effects (provided that the phytoextract is properly standardized for the active ingredients and impurities). The bioflavonoids (in particular, luteolin and luteolin-7-glucoside (L7G)) contained in the passionflower phytoextracts contribute to increasing the body’s adaptive capabilities, including stress resistance of the central nervous system, sedative and hypnotic effects, neuroprotection, and elimination of chronic inflammation.

CONCLUSION

The results of fundamental and clinical studies indicate that the effectiveness of passionflower extracts is comparable to that of synthetic hypnotic drugs.

Keywords:

sleep-wake cycle regulation

adaptation disorders

bioflavonoids

passionflower

StressOff forte

luteolin

luteolin-7-glucoside (L7G)

Authors:

Gromova O.A.

Federal Research Center «Information Science and Control» of the Russian Academy of Sciences

ORCID: 0000-0002-7663-710X

Torshin I.Yu.

Federal Research Center «Information Science and Control» of the Russian Academy of Sciences

ORCID: 0000-0002-2659-7998

Received:

09.09.2024

Accepted:

04.10.2024

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References:

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