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Samoilova Iu.G.

Siberian State Medical University

Matveeva M.V.

Siberian State Medical University

Stankova A.E.

Siberian State Medical University

Podchinenova D.V.

Siberian State Medical University

Kudlay D.A.

First Moscow State Medical University (Sechenov University);
Lomonosov Moscow State University;
State Scientific Center «Institute of Immunology»

Vaizova O.E.

Siberian State Medical University

Grishkevich I.R.

Siberian State Medical University

Effect of genetic polymorphisms on the effectiveness and safety of sodium-glucose co-transporter 2 inhibitors in treatment of type 2 diabetes mellitus

Authors:

Samoilova Iu.G., Matveeva M.V., Stankova A.E., Podchinenova D.V., Kudlay D.A., Vaizova O.E., Grishkevich I.R.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2024;27(1): 67‑71

DOI: 10.17116/profmed20242701167

Read: 1103 times

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Table of contents

EFFECT OF GENETIC POLYMORPHISMS ON THE EFFECTIVENESS AND SAFETY OF SODIUM-GLUCOSE CO-TRANSPORTER 2 INHIBITORS IN TREATMENT OF TYPE 2 DIABETES MELLITUS
EFFECT OF GENETIC POLYMORPHISMS ON THE EFFECTIVENESS AND SAFETY OF SODIUM-GLUCOSE CO-TRANSPORTER 2 INHIBITORS IN TREATMENT OF TYPE 2 DIABETES MELLITUS

To cite this article:

Samoilova IuG, Matveeva MV, Stankova AE, Podchinenova DV, Kudlay DA, Vaizova OE, Grishkevich IR. Effect of genetic polymorphisms on the effectiveness and safety of sodium-glucose co-transporter 2 inhibitors in treatment of type 2 diabetes mellitus. Russian Journal of Preventive Medicine. 2024;27(1):67‑71. (In Russ.)
https://doi.org/10.17116/profmed20242701167

Подписка 2025-2 (Russian Journal of Preventive Medicine)
 
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The review presents pharmacogenetic data proving the relationship of genetic polymorphisms of genes with the effectiveness of treatment by sodium-glucose co-transporter 2 inhibitors (SGLT2-Is) in patients with type 2 diabetes mellitus. The search of publications was carried out in the PubMed database from 2017 to 2023. Polymorphisms of some genes (SLC5A2, PNPLA3, UGT1A9) have been potentially associated with the SGLT2-Is efficacy, but obtained results do not suggest their importance for clinical practice. Further studies are necessary.

Keywords:

polymorphisms
SGLT2-Is
type 2 diabetes mellitus

Authors:

Samoilova Iu.G.

Siberian State Medical University

Matveeva M.V.

Siberian State Medical University

Stankova A.E.

Siberian State Medical University

Podchinenova D.V.

Siberian State Medical University

Kudlay D.A.

First Moscow State Medical University (Sechenov University);
Lomonosov Moscow State University;
State Scientific Center «Institute of Immunology»

Vaizova O.E.

Siberian State Medical University

Grishkevich I.R.

Siberian State Medical University

Received:

02.11.2023

Accepted:

14.12.2023

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