The purpose of the study was to estimate the combined effects of hazardous occupational exposures on the development of cardiovascular diseases. 160 male patients with hand-arm vibration syndrome (HAVS) were studied (55 having stage 1, mild, and 105 with stage 2, moderate; controls being 47 males with no HAVS). The HAVS patients were also having the initial signs of lung fibrosis resulting from their exposure to industrial dust, hearing impairment and vertebrogenic pain syndrome worsening with physically demanding activity. Standard diagnostic protocols along with high-resolution rhytmocardiography were used. Cardiovascular dysregulation was found in most of the patients and its severity well correlated with the duration of the combined exposure to occupational hazards.