Objective — to study the features of the course of pregnancy in women with antiphospholipid syndrome (APS), depending on the therapy and the presence of TORCH infection. Material and methods. 137 cards of women with a history of pregnancy termination were analyzed, divided into 2 groups according to the principle of presence/absence of plasmapheresis in the treatment regimen at the stage of pregravid preparation, followed by ranking into 2 subgroups according to the principle of presence/absence of TORCH infection activity. Results. The features of the course of pregnancy in women with APS depending on the complex therapy and the presence of TORCH infection were as follows: early toxicosis developed more than 2 times more often, regardless of the treatment regimen used, the presence or absence of TORCH infection. The threat of spontaneous miscarriage in the first trimester was almost 10 times higher than in the control group. The absence of efferent therapy in patients with TORCH infection against the background of APS led to an increase in the risk of spontaneous miscarriage up to 73%, which was more than twice as much as in patients whose plasmapheresis was included in the treatment regimen. Placental insufficiency developed 3 times more often than in the control group and 2 times more often than in the main group. In the third trimester, an increase in the risk of preterm birth was observed in all subgroups, with the exception of I2, which did not differ from the control group and was 2.9 times smaller than in the comparison subgroup. Fetal hypoxia in patients with APS, but without TORCH infection, regardless of the therapy, developed with the same probability as in the control group. The presence of TORCH infection in women with APS, whose plasmapheresis was included in the complex therapy, increased the probability of developing fetal hypoxia by more than 50%, while the absence of efferent therapy methods led to a three-fold increase in the probability of fetal suffering in relation to the control group and double — in relation to the main subgroup. Conclusion. Combined therapy for miscarriage in women with APS with the inclusion of plasmapheresis at the preconception stage, which developed against the background of TORCH infection, significantly reduces the development of pregnancy complications.