Due to the progressive decrease in the number of women of childbearing age, as well as children and adolescents in the Russian Federation, the primary medical and social task at the present stage is to preserve the reproductive health and life of women by preserving each desired preg-nancy. It is known that in more than 40% of observations the genesis of reproductive losses re-mains unclear. In Russia, the rate of miscarriage is 15—23%, in UK — 2.8%, in the USA — 15%. The share of non-developing (missed) pregnancy in the structure of early losses is up to 10—20%, while its frequency in our country increases annually. Missed abortion, as a rule, is the result of the combined effect of several factors of exogenous and endogenous origins. Exogenous factors are difficult to analyze and predict, can have a tera-togenic effect, leading to the occurrence of chromosomal abnormalities and the formation of an abnormal embryo. Endogenous factors are due to the characteristics of the female body, creating unfavorable conditions for the normal development of the embryo: anatomical, endocrine, immu-nological, infectious, etc. At the stage of pregnancy planning, endogenous factors are available for analysis and are considered conditionally controllable. Against the background of declining birth rates, the problem of non-developing pregnancy is becoming especially relevant and requires a serious analysis of the causes of its occurrence, as well as the development of possible methods of forecasting and prevention. The review article is devoted to a detailed analysis of foreign and domestic sources of literature concerning the role of maternal factors in the genesis of non-developing pregnancy as an important resource in reducing the frequency of miscarriage.