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Monakhov S.A.

I.M. Sechenov Moscow Medical Academy

Bobrovskaya L.V.

GBUZ MO «Left-bank city polyclinic», Moscow, Russia, 141411

A new view of a dermatologist on a well-known hormonal contraceptive

Authors:

Monakhov S.A., Bobrovskaya L.V.

More about the authors

Journal: Russian Journal of Human Reproduction. 2018;24(1): 48‑52

DOI: 10.17116/repro201824148-52

Views: 17475

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To cite this article:

Monakhov SA, Bobrovskaya LV. A new view of a dermatologist on a well-known hormonal contraceptive. Russian Journal of Human Reproduction. 2018;24(1):48‑52. (In Russ.)
https://doi.org/10.17116/repro201824148-52

 
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The article descibes the aspects of the influence of female sex steroids on estrogen-dependent organs and body systems. Particular attention is paid to the role of estrogen deficiency in women after 30 years, associated with it disorders of the menstrual cycle and manifestations of relative hyperandrogenism in the form of late acne. There are four main groups of patients in whom СОС Qlaira can be the drug of choice, as well as the results of joint observation by an obstetrician-gynecologist and dermatovenereologist of women with menstrual irregularities in the form of profuse menstrual bleeding and idiopathic late acne treated with Qlaira.

Keywords:

estrogens
profuse menstrual bleeding
vaginosis
contraception
relative hyperandrogenia
dienogest
Qlaira preparation

Authors:

Monakhov S.A.

I.M. Sechenov Moscow Medical Academy

Bobrovskaya L.V.

GBUZ MO «Left-bank city polyclinic», Moscow, Russia, 141411

List of references:

  1. Monakhov SA, Ivanov OL. Estrogen-gestagennye preparaty v dermatologicheskoi praktike (metodicheskoe posobie dlya vrachei). M. 2014;32. (In Russ.)
  2. Data on file. Clinical study report number B709 (protocol JPH05995) 2000 27 Jul.
  3. Wiegratz I, Lee JH, Kutschera E. Effect of four oral contraceptives on hemostatic parameters. Contraception. 2004;70:Suppl. 2:97-106.
  4. Qlaira Summary of Product Characteristics. Bayer Schering Pharma AG. 2008. Available from URL: http://emc.medicines.org.uk/medicine/21700/SPC/Qlaira/(accessed 25 February 2010)
  5. Data on file. Clinical study report A33022 (protocol 301886), 2007 12 June.
  6. Mansour D, Nelson A, Parke S. Abstract and oral presentation at 8th Congress of the European Society of Gynecology, 10—13 September 2009. Rome, Italy. Available at http://www.seg2009.com/congressonline/swf/0183.html (accessed 1 March 2010)
  7. Palacios S, Wildt L, Parke S. Efficacy and safety of a novel oral contraceptive based on oestradiol (oestradiol valerate/dienogest): a phase III trial. Eur J Obstet Gynecol. 2010;149:Suppl. 1:57-62.
  8. Caruso S, Agnello C, Intelisano G. Sexual behavior of women taking low-dose oral contraceptive containing 15 microg ethinylestradiol/60 microg gestodene. Contraception. 2004;69:Suppl. 3:237-240.
  9. Adaskevich VP. Akne vul’garnye i rozovye. M. 2003;160. (In Russ.)
  10. Suvorova KN, Gombolevskaya SL, Kamakina MV. Giperandrogennye akne u zhenshchin. Novosibirsk. 2000;124. (In Russ.)
  11. Potekaev NN, Goryachkina MV. Nekotorye aspekty diagnostiki i lecheniya refrakternykh akne u zhenshchin. Klin dermatol i venerol. 2012;2:72-78. (In Russ.)
  12. Ivanov OL, Samgin MA, Monakhov SA, L’vov AN, Uvarova EV. Zhanin v terapii akne u zhenshchin. V sb.:. Aktual’nye problemy urogenital’nykh infektsii, peredavaemykh polovym putem. Novye lekarstvennye preparaty v dermatovenerologicheskoi praktike. M. 2003;47. (In Russ.)
  13. Astedt B, Jeppsson S, Liedholm P. Clinical trial of a new oral contraceptive pill containing the natural oestrogen 17β-oestradiol. Br J Obstet Gynaecol. 1979;86:Suppl. 9:732-736.
  14. Down RH, Whiting MJ, Watts JM, Jones W. Effect of synthetic oestrogens and progestagens in oral contraceptives on bile lipid composition. Gut. 1983;24:253-259.
  15. Parke S, Junge W, Mellinger U. Comparative effects of a four-phasic regimen of estradiol valerate/dienogest versus ethinylestradiol/levonorgestrel on haemostatic parameters. Hum Reprod. 2008;23:Suppl. 1:178-179.

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