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Akulenko L.V.

Department of obstetrics and Gynecology, Stomatologic Faculty, Moscow State University of Medicine and Dentistry named after A.I. Evdokomov, Russian Federation, Moscow, Delegatskaya street, 20/1, 127473

Dzansolova A.V.

Department of obstetrics and Gynecology, Stomatologic Faculty, Moscow State University of Medicine and Dentistry named after A.I. Evdokomov, Russian Federation, Moscow, Delegatskaya street, 20/1, 127473

Mugadova Z.V.

Departvent of obstretrics and Gynecology, Stomatologic Faculty, Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, Russia, 127473

Balios L.V.

Kafedra akusherstva i ginekologii stomatologicheskogo fakul'teta Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta;
rodil'nyĭ dom #8, Moskva

Sozaeva L.G.

Kafedra akusherstva i ginekologii Rossiĭskoĭ gosudarstvennoĭ meditsinskoĭ akademii poslediplomnogo obrazovaniia, Moskva

Kuznecov V.M.

Moscow State Medico-Stomatological University A.I. Evdokimova, Department of Obstetrics and Gynecology faculty of dentistry, Branch of City Clinical Hospital 68 ,Maternity Hospital 8, Moscow, Russia, 109507

Individual approach to pridicting preeclampsia

Authors:

Akulenko L.V., Dzansolova A.V., Mugadova Z.V., Balios L.V., Sozaeva L.G., Kuznecov V.M.

More about the authors

Journal: Russian Journal of Human Reproduction. 2017;23(2): 84‑87

DOI: 10.17116/repro201723284-87

Read: 526 times

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Table of contents

INDIVIDUAL APPROACH TO PRIDICTING PREECLAMPSIA
INDIVIDUAL APPROACH TO PRIDICTING PREECLAMPSIA

To cite this article:

Akulenko LV, Dzansolova AV, Mugadova ZV, Balios LV, Sozaeva LG, Kuznecov VM. Individual approach to pridicting preeclampsia. Russian Journal of Human Reproduction. 2017;23(2):84‑87. (In Russ.)
https://doi.org/10.17116/repro201723284-87

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Objective — to develop the method of personal prediction of preeclampsisa progression on the basis of multivariant analysis of clinical, anamnestic and genotypic data. Material and methods. The results of screening of 49 patients with preeclampsisa and 48 patients with physiological pregnancy were presented. The outcome analysis was performed by methods of binary and multiple mathematical statistics. Results. Comparative analysis revealed a high frequency of cardiovascular pathology, metabolic disorders, premature birth, family history in patients of the main group compared with the control. Genetic analysis of blood samples showed a higher frequency of C4599A polymorphism of AGTR2 in patients with preeclampsia compared with healthy pregnant women (p=0.009). Conclusion. On the basis of clinical, anamnestic and genotypic data analysis a prognostic test was developed.

Keywords:

preeclampsia
the polymorphism AGTR1
AGTR2 gene

Authors:

Akulenko L.V.

Department of obstetrics and Gynecology, Stomatologic Faculty, Moscow State University of Medicine and Dentistry named after A.I. Evdokomov, Russian Federation, Moscow, Delegatskaya street, 20/1, 127473

Dzansolova A.V.

Department of obstetrics and Gynecology, Stomatologic Faculty, Moscow State University of Medicine and Dentistry named after A.I. Evdokomov, Russian Federation, Moscow, Delegatskaya street, 20/1, 127473

Mugadova Z.V.

Departvent of obstretrics and Gynecology, Stomatologic Faculty, Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, Russia, 127473

Balios L.V.

Kafedra akusherstva i ginekologii stomatologicheskogo fakul'teta Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta;
rodil'nyĭ dom #8, Moskva

Sozaeva L.G.

Kafedra akusherstva i ginekologii Rossiĭskoĭ gosudarstvennoĭ meditsinskoĭ akademii poslediplomnogo obrazovaniia, Moskva

Kuznecov V.M.

Moscow State Medico-Stomatological University A.I. Evdokimova, Department of Obstetrics and Gynecology faculty of dentistry, Branch of City Clinical Hospital 68 ,Maternity Hospital 8, Moscow, Russia, 109507

Close metadata

References:

  1. Baranov VS. Genetic passport — the basis of individual and predictive medicine. St. Petersburg. 2009;528. (In Russ.).
  2. Sidorova VN, Markin SA, Lubnin AYu. Eclampsia. M.: MIA. 2002;206.
  3. Boehlen F. Thrombocytopenia during pregnancy. Importance, diagnosis and management. Hamostaseologie. 2006;26(1):72-74.
  4. Foidart JM, Schaaps JP, Chantraine F, et al. Dysregulation of anti-angiogenic agent (sFlt-1, PLGF, and sEndoglin) in preeclampsia step forword but not the definitive answer. J Reprod Immunol. 2009;82:2:106-111.
  5. Laasanen J, Romppanen EL, Hiltunen M, et al. Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are jointly associated with preeclampsia. Eur J Hum Genet. 2002;10:9:569-573.
  6. Levine RJ, Maynard SE, Qian C, et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med. 2004;350:672-683.
  7. Matthews DE, Farewell MT. Using and understanding medical statistics. KARGER. 1988.
  8. Miller RGJr. Simultaneous statistical inference. New York: McGraw Hill. 1981.
  9. Xia Y, Kellems RE. Is preeclampsia an autoimmune disease. Clin Immunol. 2009; 133:l:1-12.
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