Immunological features of children born after very early premature births depending on gender

Lyapunov V.A.; Remizova I.I.; Gazieva I.A.

doi:https://doi.org/10.17116/repro2016225159-163

Lyapunov V.A.

FGBU «Ural Research Institute of Maternity and Infancy Welfare» Ministry Health of the Russia, Ekaterinburg, Russia, 620028

Remizova I.I.

FGBU "Ural'skiĭ nauchno-issledovatel'skiĭ institut okhrany materinstva i mladenchestva", Ekaterinburg

Gazieva I.A.

FGBU "Ural'skiĭ nauchno-issledovatel'skiĭ institut okhrany materinstva i mladenchestva", Ekaterinburg

Immunological features of children born after very early premature births depending on gender

Authors:

Lyapunov V.A., Remizova I.I., Gazieva I.A.

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Journal: Russian Journal of Human Reproduction. 2016;22(5): 159‑163

DOI: 10.17116/repro2016225159-163

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To cite this article:

Lyapunov VA, Remizova II, Gazieva IA, Remizova II. Immunological features of children born after very early premature births depending on gender. Russian Journal of Human Reproduction. 2016;22(5):159‑163. (In Russ.)
https://doi.org/10.17116/repro2016225159-163

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)

Использование инфографики авторами научных работ

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Abstract:

Objective. To identify the immunological features of the child born after very early premature births depending on the gender. Material and methods. We examined 39 boys and 35 girls with extremely low birth weight. The comparison group consisted of 31 full-term infants with uncomplicated early period of adaptation. Flow cytometry was used to determine the number of lymphocyte subpopulations and cytokine-producing cells (CD3+IFN-γ+, CD3+IL-4+); and enzyme immunoassay — for determing the levels of cytokines (IL-4, IFN-γ) and neopterin concentration in serum. Results. The boys had decreased number of CD3+, CD4+ and CD8+ subpopulyatsy, reduced content of CD3+IL-4+ cells at birth, as well as low production of IL-4 in the 1st day of life and to achieve post-conceptual age compared with term infants. The girls recorded an increase of neopterin level in the first day of life and the content of B-cell stage for nursing, the quantitative characteristics of the T-lymphocytes consistent with indicators of full-term infants, except for CD3+IL-4+ cells, the contents of which to postconceptional age significantly decreased. Conclusion.The results are indicative of greater functional immaturity of the immune system in preterm boys.

Keywords:

extremely low birth weight

immunity

gender differences

Authors:

Lyapunov V.A.

FGBU «Ural Research Institute of Maternity and Infancy Welfare» Ministry Health of the Russia, Ekaterinburg, Russia, 620028

Remizova I.I.

FGBU "Ural'skiĭ nauchno-issledovatel'skiĭ institut okhrany materinstva i mladenchestva", Ekaterinburg

Gazieva I.A.

FGBU "Ural'skiĭ nauchno-issledovatel'skiĭ institut okhrany materinstva i mladenchestva", Ekaterinburg

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References:

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