Paracrine regulation of folliculogenesis in hysterectomy

Petrov I.A.; Tikhonovskaya O.A.; Kupriyanova I.I.; Fateeva A.S.; Petrova M.S.; Logvinov S.V.

doi:https://doi.org/10.17116/repro201622522-28

Petrov I.A.

Department of Obstetrics and Gynecology, Siberian State Medical University, Ministry of Health of Russia, Tomsk, Russia

Tikhonovskaya O.A.

Department of Obstetrics and Gynecology, Siberian State Medical University, Ministry of Health of Russia, Tomsk, Russia

Kupriyanova I.I.

Siberian State Medical University, Tomsk, Russia, 634026

Fateeva A.S.

Siberian State Medical University, Tomsk, Russia, 634026

Petrova M.S.

Department of Obstetrics and Gynecology, Siberian State Medical University, Ministry of Health of Russia, Tomsk, Russia

Logvinov S.V.

Sibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Tomsk

Paracrine regulation of folliculogenesis in hysterectomy

Authors:

Petrov I.A., Tikhonovskaya O.A., Kupriyanova I.I., Fateeva A.S., Petrova M.S., Logvinov S.V.

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Journal: Russian Journal of Human Reproduction. 2016;22(5): 22‑28

DOI: 10.17116/repro201622522-28

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To cite this article:

Petrov IA, Tikhonovskaya OA, Kupriyanova II, Fateeva AS, Petrova MS, Logvinov SV. Paracrine regulation of folliculogenesis in hysterectomy. Russian Journal of Human Reproduction. 2016;22(5):22‑28. (In Russ.)
https://doi.org/10.17116/repro201622522-28

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)

Использование инфографики авторами научных работ

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Abstract:

Objective — to study the expression of BMP15, Cx37 and AMH in follicular epithelium and oocytes after removal of the uterus and fallopian tubes. Material and methods. Sexually mature female rats, outbred stock Wistar. The main group (n=30) — laparotomy, removal of uterine horns and oviducts. Control (n=12) — sham rats. Immunohistochemical study of the expression of BMP15, Cx37, AMH by high-temperature antigen unmasking on paraffin sections using a streptavidin-biotin detection system. Results. Initiation of follicular growth (reduced expression of AMH in follicular epithelium growing follicles), high competence follicle and oogenesis (increased expression of BMP15 and Cx37 in the oocytes of growing follicles) are observed in the early period after the removal of the uterus and the fallopian tubes. Relative reduction of BMP15 and Cx37 oocytes in secondary and tertiary follicles are observed by the end of the experiment. Conclusion. Hysterectomy with uterine tubes leads to activation of processes of follicular initiation and growth in the early period with subsequent impairment of final stages of follicular development and ovarian failure.

Keywords:

hysterectomy

folliculogenesis

anti-Müllerian hormone

bone morphogenetic protein

connexin

Authors:

Petrov I.A.

Department of Obstetrics and Gynecology, Siberian State Medical University, Ministry of Health of Russia, Tomsk, Russia

Tikhonovskaya O.A.

Department of Obstetrics and Gynecology, Siberian State Medical University, Ministry of Health of Russia, Tomsk, Russia

Kupriyanova I.I.

Siberian State Medical University, Tomsk, Russia, 634026

Fateeva A.S.

Siberian State Medical University, Tomsk, Russia, 634026

Petrova M.S.

Department of Obstetrics and Gynecology, Siberian State Medical University, Ministry of Health of Russia, Tomsk, Russia

Logvinov S.V.

Sibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Tomsk

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