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Absatarova Yu.S.

Institute of Reproductive Medicine and Department of Endocrinology FSBI 'National Medical Research Center of Endocrinology' Ministry of Health of Russia, Moscow, Russia

Andreeva E.N.

Mediko-geneticheskoe otdelenie Moskovskogo oblastnogo NII akusherstva i ginekologii

Sheremet'eva E.V.

FGU "Éndokrinologicheskiĭ nauchnyĭ tsentr" Minzdravsotsrazvitiia RF, Moskva

Grigorian O.R.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr Minzdravsotsrazvitiia Rossii, Moskva

Melatonin in human reproduction

Authors:

Absatarova Yu.S., Andreeva E.N., Sheremet'eva E.V., Grigorian O.R.

More about the authors

Journal: Russian Journal of Human Reproduction. 2016;22(1): 8‑11

DOI: 10.17116/repro20162218-11

Read: 8428 times

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Table of contents

MELATONIN IN HUMAN REPRODUCTION
MELATONIN IN HUMAN REPRODUCTION

To cite this article:

Absatarova YuS, Andreeva EN, Sheremet'eva EV, Grigorian OR. Melatonin in human reproduction. Russian Journal of Human Reproduction. 2016;22(1):8‑11. (In Russ.)
https://doi.org/10.17116/repro20162218-11

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The article presents the current data about the functions of melatonin, the main hormone of the pineal gland, which in addition to its regulatory ability to the circadian rhythm can act as a powerful antioxidant that regulates the oocyte growth and maturation. Its use in cycles of assisted reproductive technology provides higher quality of oocytes, which is the key to success of infertility treatment. Perspective use of melatonin preparations in patients with anovulatory infertility (especially with polycystic ovary syndrome) may become a new landmark in the endocrine gynecology.

Keywords:

melatonin
reproductive function
polycystic ovary syndrome
ovarian follicular apparatus

Authors:

Absatarova Yu.S.

Institute of Reproductive Medicine and Department of Endocrinology FSBI 'National Medical Research Center of Endocrinology' Ministry of Health of Russia, Moscow, Russia

Andreeva E.N.

Mediko-geneticheskoe otdelenie Moskovskogo oblastnogo NII akusherstva i ginekologii

Sheremet'eva E.V.

FGU "Éndokrinologicheskiĭ nauchnyĭ tsentr" Minzdravsotsrazvitiia RF, Moskva

Grigorian O.R.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr Minzdravsotsrazvitiia Rossii, Moskva

Close metadata

References:

  1. Agez L, Laurent V, Guerrero HY, Pevet P, Masson-Pevet M, Gauer F. Endogenous melatonin provides an effective circadian message to both the suprachiasmatic nuclei and the pars tuberalis of the rat. Journal of Pineal Research. 2009;46(1):95-105.  doi: 10.1111/j.1600-079X.2008.00636.x.
  2. Arendt J. Melatonin, Circadian Rhythms, and Sleep. New England Journal of Medicine. 2000;343(15):1114-1116. doi: 10.1056/nejm200010123431510.
  3. Fisher SP, Davidson K, Kulla A, Sugden D. Acute sleep-promoting action of the melatonin agonist, ramelteon, in the rat. Journal of Pineal Research. 2008;45(2):125-132.  doi: 10.1111/j.1600-079x.2008.00565.x.
  4. Geijlswijk IM, Korzilius HP, Smits MG. The use of exogenous melatonin in delayed sleep phase disorder: a metaanalysis. Sleep. 2010; 33:1605-1614.
  5. Carrillo-Vico A, Reiter RJ, Lardone PJ, Herrera JL, Fernandez-Montesinos R, Guerrero JM, and Pozo D. The modulatory role of melatonin on immune responsiveness. Current opinion in investigational drugs. 2006;7:423-431.
  6. Reiter RJ, Tan DX, Manchester LC, Paredes SD, Mayo JC, Sainz RM. Melatonin and reproduction revisited. Biology of Reproduction. 2009;81:445-456.  doi: 10.1095/biolreprod.108.075655.
  7. Reiter RJ, Rosales-Corral SA, Manchester LC, Tan DX. Peripheral reproductive organ health and melatonin: ready for prime time. International Journal of Molecular Sciences. 2013;14:7231-7272. doi:10.3390/ijms14047231.
  8. Tamura H, Nakamura Y, Korkmaz A, Manchester LC, Tan D-X, Sugino N, Reiter R J. Melatonin and the ovary: physiological and pathophysiological implications. Fertility and Sterility. 2009;92:328-343. doi: 10.1016/j.fertnstert.2008.05.016.
  9. Lowes DA, Webster NR, Murphy MP, Galley HF. Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in rat a model of acute sepsis. British Journal of Anaesthesia. 2013;110:472-480. doi: 10.1093/bja/aes577.
  10. Hardeland R. Antioxidative protection by melatonin: multiplicity of mechanisms from radical detoxification to radical avoidance. Endocrine. 2005;27:119-130.  doi: 10.1385/endo:27:2:119
  11. Urata Y, Honma S, Goto S, Todoroki S, Iida T, Cho S, Honma K, Kondo T. Melatonin induces gammaglutamylcysteine synthase mediated by activator protein-1 in human vascular endothelial cells. Free Radical Biology and Medicine. 1999;27:838-847.  doi: 10.1016/s0891-5849(99)00131-8.
  12. Tan D, Manchester LC, Hardeland R, Lopez-Burillo S, Mayo JC, Sainz RM, Reiter RJ. Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin. Journal of Pineal Research. 2003;34:75-78.  doi: 10.1034/j.1600-079x.2003.02111.x.
  13. Itoh MT, Ishizuka B, Kudo Y, Fusama S, Amemiya A, Sumi Y. Detection of melatonin and serotonin N-acetyltransferase and hydroxyindole-O-methyltransferase activities in rat ovary. Molecular and Cellular Endocrinology. 1997;136(1):7-13.  doi: 10.1016/s0303-7207(97)00206-2.
  14. Itoh MT, Ishizuka B, Kuribayashi Y. Melatonin, its precursors and synthesizing enzyme activities in the human ovary. Molecular Human Reproduction. 1999;5:402-408.  doi: 10.1093/molehr/5.5.402.
  15. Slominski RM, Reiter RJ, Schlabritz-Loutsevitch N, Ostrom RS, Slominski AT. Melatonin membrane receptors in peripheral tissues: Distribution and functions. Molecular and Cellular Endocrinology. 2012;35:152-166.  doi: 10.1016/j.mce.2012.01.004.
  16. El-Raey M, Geshi M, Somfai T, Kaneda M, Hirako M, Abdel-Ghaffar A, Sosa G, El-Roos A, Nagai T. Evidence of melatonin synthesis in the cumulus oocyte complexes and its role in enhancing oocyte maturation in vitro in cattle. Molecular Reproduction and Development. 2011;78(4), 250-262.  doi: 10.1002/mrd.21295.
  17. Tan D-X, Manchester LC, Hardeland R, Lopez-Burillo S, Mayo JC, Sainz RM, Reiter R. Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin. Journal of Pineal Research. 2003;34:75-78.  doi: 10.1034/j.1600-079x.2003.02111.x.
  18. Nakamura Y, Tamura H, Tamayama H, Kato H. Increased endogenous level of melatonin in preovulatory human follicles does not directly influence progesterone production. Fertility and Sterility. 2003;80:1012-1016. doi: 10.1016/s0015-0282(03)01008-2.
  19. Soares JM, Masana MI, Ersahin C, Dubocovich ML. Functional melatonin receptors in rat ovaries at various stages of the estrous cycle. Journal of Pharmacology and Experimental Therapeutics. 2003;306:694-702.  doi: 10.1124/jpet.103.049916.
  20. Tamura H, Taksaki A, Taketani T, Tanabe M, Kizuka F, Lee L, Tamura I, Maekawa R, Asada H, Yamagata Y, Sugino N. Melatonin as a free radical scavenger in the ovarian follicle. Endocrine journal. 2013;60:1-13. doi: 10.1507/endocrj.ej12-0263.
  21. Zuelke K, Jones D, Perreault S. Glutathione oxidation is associated with altered microtubule function and disrupted fertilization in mature hamster oocytes. Biology of Reproduction. 1997;57:1413-1419. doi: 10.1095/biolreprod57.6.1413.
  22. Tatemoto H, Muto N, Sunagawa I. Protection of procine oocytes against cell damage caused by oxidative stress during in vitro maturation: role of superoxide dismutase activity in porcine follicular fluid. Biology of Reproduction. 2004;71:1150-1157. doi: 10.1095/biolreprod.104.029264.
  23. Tamura H, Takasaki A, Taketani T, Tanabe M, Kizuka F, Lee L, Tamura I, Maekawa R, Aasada H, Yamagata Y, Sugino N. The role of melatonin as an antioxidant in the follicle. Journal of ovarian research. 2012;5:5.  doi: 10.1186/1757-2215-5-5.
  24. Kang JT, Koo OJ, Kwon DK, Park HJ, Jang G, Kang SK, Lee BC. Effects of melatonin on in vitro maturation of porcine oocyte and expression of melatonin receptor RNA in cumulus and granulosa cells. Journal of pineal research. 2009;46(1):22-28.  doi: 10.1111/j.1600-079X.2008.00602.x.
  25. Ishizuka B, Kuribayashi Y, Murai K, Amemiya A, Itoh MT. The effect of melatonin on in vitro fertilization and embryo development in mice. Journal of pineal research. 2000;28:48-51.
  26. Tamura H, Takasaki A, Miwa I, Taniguchi K, Maekawa R, Asada H, Taketani T, Matsuoka A, Yamagata Y, Shimamura K, Morioka H, Ishikawa H, Reiter RJ, Sugino N. Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate. Journal of pineal research. 2008;44:280-287.  doi: 10.1111/j.1600-079X.2007.00524.x.
  27. Tamura H, Nakamura Y, Terron M, Flores L, Manchester L, Tan D, Sugino N, Reiter R. Melatonin and pregnancy in the human. Reproductive Toxicology. 2008;25:291-303.  doi: 10.1016/j.reprotox.2008.03.005.
  28. Kim MK, Park EA, Kim HJ, Choi WY, Cho JH, Lee WS, Cha KY, Kim YS, Lee DR, Yoon TK. Does melatonin supplementation of in-vitro culture medium with melatonin improve IVF outcome in PCOS? Reproductive biomedicine online. 2013;26:22-26. doi: 10.1016/j.rbmo.2012.10.007.
  29. Gonzalez F, Rote NS, Minium J, Kirwan JP. Reactive oxygen species induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndrome. The Journal of clinical endocrinology and metabolism. 2006;91:336-340.  doi: 10.1210/jc.2005-1696.
  30. Yildirim B, Demir S, Temur I, Erdemir R, Kaleli B. Lipid peroxidation in follicular fluid of women with polycystic ovary syndrome during assisted reproduction cycles. The Journal of reproductive medicine. 2007;52:722-726.
  31. Canuto R, Pattussi M, Macagnan J, Henn R, Olinto M. Sleep deprivation and obesity in shift workers in southern Brazil. Public Health Nutrition. 2013;29:1-5.  doi: 10.1017/S1368980013002838.
  32. Kim MJ, Son KH, Park HY, Choi DJ, Yoon CH, Lee HY, Cho EY, Cho MC. Association between shift work and obesity among female nurses: Korean Nurses' survey. BMC Public Health. 2013; 13:1204. doi: 10.1186/1471-2458-13-1204.
  33. Cipolla-Neto J, Amaral F, Afeche S, Tan D, Reiter R. Melatonin, energy metabolism, and obesity: a review. Journal of Pineal Research. 2014;56(4):371-381. doi: 10.1111/jpi.12137.
  34. Leproult R, Holmbäck U, van Cauter E. Circadian misalignment augments markers of insulin resistance and inflammation, independently of sleep loss. Diabetes. 2014;63(6):1860-1869. doi: 10.2337/db13-1546.
  35. Esquirol Y, Bongard V, Ferrieres J, Verdier H, Perret B. Shiftwork and higher pancreatic secretion: early detection of an intermediate state of insulin resistance? Chronobiology International. 2012;29(9):1258-1266. doi: 10.3109/07420528.2012.719959.
  36. Dochi M, Suwazono Y, Sakata K, Okubo Y, Oishi M, Tanaka K, Kobayashi E, Nogawa K. Shift work is a risk factor for increased total cholesterol level: a 14-year prospective cohort study in 6886 male workers. Occupational and Environmental Medicine. 2009;66(9):592-597.  doi: 10.1136/oem.2008.042176.
  37. Li Y, Sato Y, Yamaguchi N. Shift work and the risk of metabolic syndrome: a nested case-control study. International Journal of Occupational and Environmental Health. 2011;17(2):154-160.  doi: 10.1179/107735211799030960.
  38. Pai SA, Majumdar AS. Protective effects of melatonin against metabolic and reproductive disturbances in polycystic ovary syndrome in rats. The Journal of pharmacy and pharmacology. 2014;66:1710-1721. doi: 10.1111/jphp.12297.
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