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Lokshin V.N.

Institute of Reproductive Medicine, IVF Center LLP, Almaty, The Republic of Kazakhstan, 050012

Kozlova N.V.

Institute of Reproductive Medicine, IVF Center LLP, Almaty, The Republic of Kazakhstan, 050012

Nigmatova N.P.

(Executive Director — obstetrician-gynecologist of the highest category, MD, PhD — T.M. Dzhusubalieva) ,The National Research Center of Maternity and Childhood, ART Department, Astana, The Republic of Kazakhstan, 010000

Modern methods of mitochondrial DNA mutations transmission preventing

Authors:

Lokshin V.N., Kozlova N.V., Nigmatova N.P.

More about the authors

Journal: Russian Journal of Human Reproduction. 2015;21(6): 77‑84

DOI: 10.17116/repro201521669-76

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MODERN METHODS OF MITOCHONDRIAL DNA MUTATIONS TRANSMISSION PREVENTING
MODERN METHODS OF MITOCHONDRIAL DNA MUTATIONS TRANSMISSION PREVENTING

To cite this article:

Lokshin VN, Kozlova NV, Nigmatova NP. Modern methods of mitochondrial DNA mutations transmission preventing. Russian Journal of Human Reproduction. 2015;21(6):77‑84. (In Russ.)
https://doi.org/10.17116/repro201521669-76

Подписка 2025-2 (Russian Journal of Human Reproduction)
 
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Prospective micromanipulation techniques with pronuclei of zygotes, division spindle and polar bodies are promising in addressing the urgent problem of the clinical treatment of mitochondrial disorders. Despite the technical and ethical problems of these approaches, mitochondrial donation has great potential to enable women carrying mutations in mtDNA have a genetically related child without transfer of mutant mtDNA, thereby preventing transmission of the mtDNA disease.

Keywords:

mitochondrial replacement
mtDNA
assisted reproduction

Authors:

Lokshin V.N.

Institute of Reproductive Medicine, IVF Center LLP, Almaty, The Republic of Kazakhstan, 050012

Kozlova N.V.

Institute of Reproductive Medicine, IVF Center LLP, Almaty, The Republic of Kazakhstan, 050012

Nigmatova N.P.

(Executive Director — obstetrician-gynecologist of the highest category, MD, PhD — T.M. Dzhusubalieva) ,The National Research Center of Maternity and Childhood, ART Department, Astana, The Republic of Kazakhstan, 010000

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