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Manturova N.E.

Pirogov Russian National Research Medical University

Stupin V.A.

Pirogov Russian National Research Medical University

Silina E.V.

Sechenov First Moscow State Medical University (Sechenov University)

Cerium oxide nanoparticles for surgery, plastic surgery and aesthetic medicine

Authors:

Manturova N.E., Stupin V.A., Silina E.V.

More about the authors

Journal: Plastic Surgery and Aesthetic Medicine. 2023;(3): 120‑129

DOI: 10.17116/plast.hirurgia2023031120

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Table of contents

CERIUM OXIDE NANOPARTICLES FOR SURGERY, PLASTIC SURGERY AND AESTHETIC MEDICINE
CERIUM OXIDE NANOPARTICLES FOR SURGERY, PLASTIC SURGERY AND AESTHETIC MEDICINE

To cite this article:

Manturova NE, Stupin VA, Silina EV. Cerium oxide nanoparticles for surgery, plastic surgery and aesthetic medicine. Plastic Surgery and Aesthetic Medicine. 2023;(3):120‑129. (In Russ., In Engl.)
https://doi.org/10.17116/plast.hirurgia2023031120

Подписка 2025-2 (Plastic Surgery and Aesthetic Medicine)
 
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The rapid development of nanotechnology and obtaining high results in the use of metal nanoparticles with variable valence, including cerium oxide nanoparticles (CONPs), makes it necessary to analyze the possibilities of its application for medical purposes.

OBJECTIVE

To review the world literature and study the achievements in the issue of new biological effects of CONPs, which may be useful in the professional work of general and plastic surgeons.

MATERIAL AND METHODS

We searched the Scopus and PubMed/Medline databases to July 2023. Inclusion criteria were publications that investigated the role of cerium oxide nanoparticles. According to the Scopus database, there were 15.762 such works, in PubMed — 2.870 (since 1997). Additional filters were chosen for biological activity: antioxidant, anti-inflammatory, antimicrobial action, wound healing, regeneration, surgery, plastic surgery.

RESULTS

It has been shown that the efficiency of CONPs depends on the size and shape of nanoparticles, concentration, chemical composition of the particle surface, surface coating, pH of the medium, and others. The possibilities of creating multicomponent implants with CONPs and cell cultures, including created through 3D printing. Despite the overall significant number of publications about CONPs and the receipt of a large number of encouraging results, the road to the creation of new drugs based on CONPs is just beginning.

CONCLUSION

An integrated interdisciplinary approach with the interaction of specialists in the fields of chemistry, biophysics, biology, and medicine will overcome difficulties by creating a new smart connection that can form the basis of several series of different medical devices, highly effective drugs and bionanotechnologies, including for general and plastic surgery, cosmetologists and aesthetic medicine.

Keywords:

nanoparticles
cerium oxide
antioxidant
antimicrobial effect
regeneration
nanotechnology for implants and 3D printing

Authors:

Manturova N.E.

Pirogov Russian National Research Medical University

Stupin V.A.

Pirogov Russian National Research Medical University

Silina E.V.

Sechenov First Moscow State Medical University (Sechenov University)

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