Connective tissue dysplasia (CTD) is a heterogeneous group of diseases caused by defects in genes responsible for synthesis of all components of extracellular matrix and subsequent post-transcriptional modifications. Phenotypic signs of CTD are described in the form of clinical and functional syndromes such as cosmetic syndrome accompanied by specific changes in appearance and early signs of aging. CTD-related changes are often observed in periorbital region and include folds, creases, hernias and furrows. This leads to dysphoria, decrease in quality of life and referring to cosmetologists and plastic surgeons. Patients with CTD have low regenerative potential of skin, barrier dysfunction, impaired regulatory molecular mechanisms and signaling pathways of connective tissue metabolism. This changes reparative processes and increases the risk of pathological scarring and complications. Various clinical manifestations complicate diagnosis and require a good knowledge of associated changes in all organs and systems. To optimize outpatient screening of CTD, a questionnaire “Characteristics of dysplastic phenotype in invasive procedures and manipulations” was developed. This tool is valuable in assessing the state of connective tissue. CURACEN intradermal biocorrector in complex protocols makes possible to reduce severity of metabolic disorders associated with dysplasia. Indeed, this biocorrector regulates metabolism of dermal connective tissue, activates self-regulation mechanisms and restores signaling pathways.