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Manturova N.E.

Kafedra plasticheskoĭ i ésteticheskoĭ khirurgii, kosmetologii i kletochnykh tekhnologiĭ GBOU VPO "Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova" Minzdravsotsrazvitiia Rossii

Mel'nikov D.V.

Kafedra plasticheskoĭ khirurgii Pervogo Moskovskogo gosudarstvennogo meditsinskogo universiteta im. I.M. Sechenova

Startseva O.I.

Rossiĭskiĭ nauchnyĭ tsentr khirurgii im. akad. B.V. Petrovskogo RAMN, Moskva

Prudnikova D.K.

Sechenov First Moscow State Medical University of the Ministry of Health of Russia, Moscow, Russia

Petruchuk V.A.

Sechenov First Moscow State Medical University of the Ministry of Health of Russia, Moscow, Russia

Large cell breast implant-associated lymphoma — current state of the problem

Authors:

Manturova N.E., Mel'nikov D.V., Startseva O.I., Prudnikova D.K., Petruchuk V.A.

More about the authors

Journal: Plastic Surgery and Aesthetic Medicine. 2020;(1): 69‑78

DOI: 10.17116/plast.hirurgia202001169

Read: 7861 times

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Table of contents

LARGE CELL BREAST IMPLANT-ASSOCIATED LYMPHOMA — CURRENT STATE OF THE PROBLEM
LARGE CELL BREAST IMPLANT-ASSOCIATED LYMPHOMA — CURRENT STATE OF THE PROBLEM

To cite this article:

Manturova NE, Mel'nikov DV, Startseva OI, Prudnikova DK, Petruchuk VA. Large cell breast implant-associated lymphoma — current state of the problem. Plastic Surgery and Aesthetic Medicine. 2020;(1):69‑78. (In Russ.)
https://doi.org/10.17116/plast.hirurgia202001169

Подписка 2026 Пластическая хирургия и эстетическая медицина (Plastic Surgery and Aesthetic Medicine)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

We analyzed data on cases of large-cell breast implant-associated lymphoma from the first description of this disease to modern information obtained from the constantly updated PROFILE world registry, as well as state registries in Australia, France, Italy and the UK. Information on the methods of diagnosis, treatment, staging of disease and prognosis was collected.

Keywords:

anaplastic large-cell breast implant-associated lymphoma (BIA-ALCL)
non-Hodgkin lymphoma
lymphoma
textured implants
breast augmentation
breast implants

Authors:

Manturova N.E.

Kafedra plasticheskoĭ i ésteticheskoĭ khirurgii, kosmetologii i kletochnykh tekhnologiĭ GBOU VPO "Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova" Minzdravsotsrazvitiia Rossii

Mel'nikov D.V.

Kafedra plasticheskoĭ khirurgii Pervogo Moskovskogo gosudarstvennogo meditsinskogo universiteta im. I.M. Sechenova

Startseva O.I.

Rossiĭskiĭ nauchnyĭ tsentr khirurgii im. akad. B.V. Petrovskogo RAMN, Moskva

Prudnikova D.K.

Sechenov First Moscow State Medical University of the Ministry of Health of Russia, Moscow, Russia

Petruchuk V.A.

Sechenov First Moscow State Medical University of the Ministry of Health of Russia, Moscow, Russia

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References:

  1. Kaprin AD, Starinskij VV, Petrova GV. Zlokachestvennye novoobrazovaniya v Rossii v 2017 g. (zabolevaemost’ i smertnost’). M.: MNIOI im. P.A. Gercena filial FGBU «NMIRC» Minzdrava Rossii; 2018. (In Russ.)
  2. Keech J, Creech B. Anfplastic T-cell Lymphoma in Proximity to a Saline-filled Breast Implant. Plastic & Reconstructive Surgery. 1997;100(2):554-555. https://doi.org/10.1097/00006534-199708000-00065
  3. Feldman AL, Harris NL, Stein H. Breast implant-associated anaplastic large cell lymphoma. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Swerdlow SH, Campo E, Harris NL et al., eds. 4th ed. Lyon, France: International Agency for Research on Cancer; 2017.
  4. Montes-Mojarro I, Steinhilber J, Bonzheim I, Quintanilla-Martinez L, Fend F. The Pathological Spectrum of Systemic Anaplastic Large Cell Lymphoma (ALCL). Cancers (Basel). 2018;10(4):107. https://doi.org/10.3390/cancers10040107
  5. Clemens M, Horwitz S. NCCN Consensus Guidelines for the Diagnosis and Management of Breast Implant-Associated Anaplastic Large Cell Lymphoma. Aesthet Surg J. 2017;37(3):285-289. https://doi.org/10.1093/asj/sjw259
  6. Clemens M, Brody G, Mahabir R, Miranda R. How to Diagnose and Treat Breast Implant — Associated Anaplastic Large Cell Lymphoma. Plast Reconstr Surg. 2018;141(4):586-599. https://doi.org/10.1097/prs.0000000000004262
  7. Thoma A, Kaur MN, Farrokhyar F, Waltho D, Levis C, Lovrics P, Goldsmith CH. Users’ guide to the surgical literature: how to assess an article about harm in surgery. Canadian Journal of Surgery. 2016;59(5):351-357. https://doi.org/10.1503/cjs.015115
  8. Roberts J, Carr L, Jones A, Schilling A, Mackay D, Potochny J. A Prospective Approach to Inform and Treat 1340 Patients at Risk for BIA-ALCL. Plast Reconstr Surg. 2019;144(1):46-54. https://doi.org/10.1097/prs.0000000000005703
  9. Miranda RN, Medeiros LJ, Ferrufino-Schmidt MC, Keech JA Jr, Brody GS, de Jong D, Dogan A, Clemens MW. Pioneers of Breast Implant-Associated Anaplastic Large Cell Lymphoma. Plast Reconstr Surg. 2019;143:7-14. https://doi.org/10.1097/prs.0000000000005564
  10. Brody GS, Deapen D, Taylor CR, Pinter-Brown L, House-Lightner SR, Andersen JS, Carlson G, Lechner MG, Epstein AL. Anaplastic Large Cell Lymphoma Occurring in Women with Breast Implants. Plast Reconstr Surg. 2015;135(3):695-705. https://doi.org/10.1097/prs.0000000000001033
  11. Collett D, Rakhorst H, Lennox P, Magnusson M, Cooter R, Deva A. Current Risk Estimate of Breast Implant-Associated Anaplastic Large Cell Lymphoma in Textured Breast Implants. Plast Reconstr Surg. 2019;143:30-40. https://doi.org/10.1097/prs.0000000000005567
  12. Nava MB, Adams WP Jr, Botti G, Campanale A, Catanuto G, Clemens MW, Del Vecchio DA, De Vita R, Di Napoli A, Hall-Findlay E, Hammond D, Heden P, Mallucci P, Martin Del Yerro JL, Muti E, Rancati A, Randquist C, Salgarello M, Stan C, Rocco N. MBN 2016 Aesthetic Breast Meeting BIA-ALCL Consensus Conference Report. Plast Reconstr Surg. 2018;141(1):40-48. https://doi.org/10.1097/prs.0000000000003933
  13. Kadin ME, Deva A, Xu H, Morgan J, Khare P, MacLeod RA, Van Natta BW, Adams WP Jr, Brody GS, Epstein AL. Biomarkers Provide Clues to Early Events in the Pathogenesis of Breast Implant-Associated Anaplastic Large Cell Lymphoma. Aesthet Surg J. 2016;36(7):773-781. https://doi.org/10.1093/asj/sjw023
  14. Deva A, Adams W, Vickery K. The Role of Bacterial Biofilms in Device-Associated Infection. Plast Reconstr Surg. 2013;132(5):1319-1328. https://doi.org/10.1097/prs.0b013e3182a3c105
  15. Hu H, Jacombs A, Vickery K, Merten S, Pennington D, Deva A. Chronic Biofilm Infection in Breast Implants Is Associated with an Increased T-Cell Lymphocytic Infiltrate. Plast Reconstr Surg. 2015;135(2):319-329. https://doi.org/10.1097/prs.0000000000000886
  16. Clemens M, Nava M, Rocco N, Miranda R. Understanding rare adverse sequelae of breast implants: anaplastic large-cell lymphoma, late seromas, and double capsules. Gland Surg. 2017;6(2):169-184. https://doi.org/10.21037/gs.2016.11.03
  17. Clemens M, Miranda R. Commentary on: Lymphomas Associated With Breast Implants: A Review of the Literature: Table 1. Aesthet Surg J. 2015;35(5):545-547. https://doi.org/10.1093/asj/sjv056
  18. Falini B, Pileri S, Pizzolo G, Dürkop H, Flenghi L, Stirpe F, Martelli MF, Stein H. CD30 (Ki-1) molecule: a new cytokine receptor of the tumor necrosis factor receptor superfamily as a tool for diagnosis and immunotherapy. Blood. 1995;85(1):1-14. https://doi.org/10.1182/blood.v85.1.1.bloodjournal8511
  19. Taylor CR, Siddiqi IN, Brody GS. Anaplastic large cell lymphoma occurring in association with breast implants: review of pathologic and immunohistochemical features in 103 cases. Appl Immunohistochem Mol Morphol. 2013;21:13-20. https://doi.org/10.1097/PAI.0b013e318266476c
  20. Blombery P, Thompson E, Prince H. Molecular Drivers of Breast Implant — Associated Anaplastic Large Cell Lymphoma. Plast Reconstr Surg. 2019;143:59-64. https://doi.org/10.1097/prs.0000000000005570
  21. Blombery P, Thompson E, Ryland GL, Joyce R, Byrne DJ, Khoo C, Lade S, Hertzberg M, Hapgood G, Marlton P, Deva A, Lindeman G, Fox S, Westerman D, Prince M. Frequent activating STAT3 mutations and novel recurrent genomic abnormalities detected in breast implant-associated anaplastic large cell lymphoma. Oncotarget. 2018;9(90):36126-36136. https://doi.org/10.18632/oncotarget.26308
  22. Pastorello RG, D’Almeida FC, Osório C, Makdissi F, Bezerra SM, de Brot M, Campos AH, Soares FA, Vassallo J. Breast implant-associated anaplastic large cell lymphoma in a Li-FRAUMENI patient: a case report. Diagn Pathol. 2018;13:10. https://doi.org/10.1186/s13000-018-0688-x
  23. Lee Y, Filie A, Arthur D, Fojo A, Jaffe E. Breast implant-associated anaplastic large cell lymphoma in a patient with Li-Fraumeni syndrome. Histopathology. 2015;67(6):925-927. https://doi.org/10.1111/his.12737
  24. Abramo A, De Oliveira V, Ledo-Silva M, De Oliveira E. How Texture-Inducing Contraction Vectors Affect the Fibrous Capsule Shrinkage Around Breasts Implants? Aesthetic Plast Surg. 2010;34(5):555-560. https://doi.org/10.1007/s00266-010-9495-9
  25. Maxwell G, Scheflan M, Spear S, Nava M, Hedén P. Benefits and Limitations of Macrotextured Breast Implants and Consensus Recommendations for Optimizing Their Effectiveness. Aesthet Surg J. 2014;34(6):876-881. https://doi.org/10.1177/1090820x14538635
  26. de Boer M, Hauptmann M, de Jong D, van Leeuwen F, Rakhorst H, van der Hulst R. Macrotextured Breast Implants with Defined Steps to Minimize Bacterial Contamination around the Device. Plast Reconstr Surg. 2018;142(4):590-591. https://doi.org/10.1097/prs.0000000000004783
  27. Magnusson M, Beath K, Cooter R, Locke M, Prince HM, Elder E, Deva AK. The Epidemiology of Breast Implant—Associated Anaplastic Large Cell Lymphoma in Australia and New Zealand Confirms the Highest Risk for Grade 4 Surface Breast Implants. Plast Reconstr Surg. 2019;143(5):1285-1292. https://doi.org/10.1097/prs.0000000000005500
  28. Danino MA, Efanov JI, Dimitropoulos G, Moreau M, Maalouf C, Nelea M, Izadpanah A, Giot JP. Capsular Biofilm Formation at the Interface of Textured Expanders and Human Acellular Dermal Matrix. Plast Reconstr Surg. 2018;141(4):919-928. https://doi.org/10.1097/prs.0000000000004216
  29. McCarthy CM, Loyo-Berríos N, Qureshi AA, Mullen E, Gordillo G, Pusic AL, Ashar BS, Sommers K, Clemens MW. Patient Registry and Outcomes for Breast Implants and Anaplastic Large Cell Lymphoma Etiology and Epidemiology (PROFILE). Plast Reconstr Surg. 2019;143:65-73. https://doi.org/10.1097/prs.0000000000005571
  30. Clemens M, Miranda R. Coming of Age. Clin Plast Surg. 2015;42(4):605-613. https://doi.org/10.1016/j.cps.2015.06.006
  31. Clemens MW, Medeiros LJ, Butler CE, Hunt KK, Fanale MA, Horwitz S, Weisenburger DD, Liu J, Morgan EA, Kanagal-Shamanna R, Parkash V, Ning J, Sohani AR, Ferry JA, Mehta-Shah N, Dogan A, Liu H, Thormann N, Di Napoli A, Lade S, Piccolini J, Reyes R, Williams T, McCarthy CM, Hanson SE, Nastoupil LJ, Gaur R, Oki Y, Young KH, Miranda RN. Complete Surgical Excision Is Essential for the Management of Patients With Breast Implant-Associated Anaplastic Large-Cell Lymphoma. Journal of Clinical Oncology. 2016;34(2):160-168. https://doi.org/10.1200/jco.2015.63.3412
  32. Loch-Wilkinson A, Beath KJ, Knight RJW, Wessels WLF, Magnusson M, Papadopoulos T, Connell T, Lofts J, Locke M, Hopper I, Cooter R, Vickery K, Joshi PA, Prince HM, Deva AK. Breast Implant-Associated Anaplastic Large Cell Lymphoma in Australia and New Zealand. Plast Reconstr Surg. 2017;140(4):645-654. https://doi.org/10.1097/prs.0000000000003654
  33. Clemens M, Jacobsen E, Horwitz S. 2019 NCCN Consensus Guidelines on the Diagnosis and Treatment of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL). Aesthet Surg J. 2019;39(suppl 1):3-13. https://doi.org/10.1093/asj/sjy331
  34. Adrada BE, Miranda RN, Rauch GM, Arribas E, Kanagal-Shamanna R, Clemens MW, Fanale M, Haideri N, Mustafa E, Larrinaga J, Reisman NR, Jaso J, You MJ, Young KH, Medeiros LJ, Yang W. Breast implant-associated anaplastic large cell lymphoma: sensitivity, specificity, and findings of imaging studies in 44 patients. Breast Cancer Res Treat. 2014;147(1):1-14. https://doi.org/10.1007/s10549-014-3034-3
  35. Ferrufino-Schmidt MC, Medeiros LJ, Liu H, Clemens MW, Hunt KK, Laurent C, Lofts J, Amin MB, Ming Chai S, Morine A, Di Napoli A, Dogan A, Parkash V, Bhagat G, Tritz D, Quesada AE, Pina-Oviedo S, Hu Q, Garcia-Gomez FJ, Jose Borrero J, Horna P, Thakral B, Narbaitz M, Hughes RC 3rd, Yang LJ, Fromm JR, Wu D, Zhang D, Sohani AR, Hunt J, Vadlamani IU, Morgan EA, Ferry JA, Szigeti R, C Tardio J, Granados R, Dertinger S, Offner FA, Pircher A, Hosry J, Young KH, Miranda RN. Clinicopathologic Features and Prognostic Impact of Lymph Node Involvement in Patients With Breast Implant-associated Anaplastic Large Cell Lymphoma. Am J Surg Pathol. 2018;42(3):293-305. https://doi.org/10.1097/pas.0000000000000985
  36. Chott A, Vonderheid E, Olbricht S, Miao N, Balk S, Kadin M. The Same Dominant T Cell Clone Is Present in Multiple Regressing Skin Lesions and Associated T Cell Lymphomas of Patients with Lymphomatoid Papulosis. Journal of Investigative Dermatology. 1996;106(4):696-700. https://doi.org/10.1111/1523-1747.ep12345532
  37. Roden A, Macon W, Keeney G, Myers J, Feldman A, Dogan A. Seroma-associated primary anaplastic large-cell lymphoma adjacent to breast implants: an indolent T-cell lymphoproliferative disorder. Modern Pathology. 2008;21(4):455-463. https://doi.org/10.1038/modpathol.3801024
  38. Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; Italian Lymphoma Foundation; European Organisation for Research; Treatment of Cancer/Dutch Hemato-Oncology Group; Grupo Español de Médula Ósea; German High-Grade Lymphoma Study Group; German Hodgkin’s Study Group; Japanese Lymphorra Study Group; Lymphoma Study Association; NCIC Clinical Trials Group; Nordic Lymphoma Study Group; Southwest Oncology Group; United Kingdom National Cancer Research Institute. Recommendations for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The Lugano Classification. Journal of Clinical Oncology. 2014;32(27):3059-3067. https://doi.org/10.1200/jco.2013.54.8800
  39. Prince HM, Kim YH, Horwitz SM, Dummer R, Scarisbrick J, Quaglino P, Zinzani PL, Wolter P, Sanches JA, Ortiz-Romero PL, Akilov OE, Geskin L, Trotman J, Taylor K, Dalle S, Weichenthal M, Walewski J, Fisher D, Dréno B, Stadler R, Feldman T, Kuzel TM, Wang Y, Palanca-Wessels MC, Zagadailov E, Trepicchio WL, Zhang W, Lin HM, Liu Y, Huebner D, Little M, Whittaker S, Duvic M; ALCANZA study group. Brentuximab vedotin or physician’s choice in CD30-positive cutaneous T-cell lymphoma (ALCANZA): an international, open-label, randomised, phase 3, multicentre trial. The Lancet. 2017;390(10094):555-566. https://doi.org/10.1016/s0140-6736(17)31266-7
  40. Johnson L, O’Donoghue JM, McLean N, Turton P, Khan AA, Turner SD, Lennard A, Collis N, Butterworth M, Gui G, Bristol J, Hurren J, Smith S, Grover K, Spyrou G, Krupa K, Azmy IA, Young IE, Staiano JJ, Khalil H, MacNeill FA. Breast implant associated anaplastic large cell lymphoma: The UK experience. Recommendations on its management and implications for informed consent. European Journal of Surgical Oncology (EJSO). 2017;43(8):1393-1401. https://doi.org/10.1016/j.ejso.2017.05.004
  41. Wieser I, Wohlmuth C, Nunez C, Duvic M. Lymphomatoid Papulosis in Children and Adolescents: A Systematic Review. Am J Clin Dermatol. 2016;17(4):319-327. https://doi.org/10.1007/s40257-016-0192-6
  42. Carty MJ, Pribaz JJ, Antin JH, Volpicelli ER, Toomey CE, Farkash EA, Hochberg EP. A Patient Death Attributable to Implant-Related Primary Anaplastic Large Cell Lymphoma of the Breast. Plast Reconstr Surg. 2011;128(3):112-118. https://doi.org/10.1097/prs.0b013e318221db96
  43. Ivaldi C, Perchenet A, Jallut Y, Casanova D. À propos de deux cas de lymphome mammaire sur coque périprothétique: un diagnostic difficile; une pathologie méconnue. Annales de Chirurgie Plastique Esthétique. 2013;58(6):688-693. https://doi.org/10.1016/j.anplas.2013.04.003
  44. Collins MS, Miranda RN, Medeiros LJ, Silva de Meneses MP, Iyer SP, Butler CE, Liu J, Clemens MW. Characteristics and Treatment of Advanced Breast Implant — Associated Anaplastic Large Cell Lymphoma. Plast Reconstr Surg. 2019;143:41-50. https://doi.org/10.1097/prs.0000000000005568
  45. Johnson L, O’Donoghue JM, McLean N, Turton P, Khan AA, Turner SD, Lennard A, Collis N, Butterworth M, Gui G, Bristol J, Hurren J, Smith S, Grover K, Spyrou G, Krupa K, Azmy IA, Young IE, Staiano JJ, Khalil H, MacNeill FA. Breast implant associated anaplastic large cell lymphoma: The UK experience. Recommendations on its management and implications for informed consent. European Journal of Surgical Oncology (EJSO). 2017;43(8):1393-1401. https://doi.org/10.1016/j.ejso.2017.05.004
  46. Cheah M, Siotos C, Rosson G, Cooney C. MBN 2016 Aesthetic Breast Meeting BIA-ALCL Consensus Conference Report. Plast Reconstr Surg. 2018;142(6):971-972. https://doi.org/10.1097/prs.0000000000005018
  47. Horwitz SM, Zelenetz AD, Gordon LI, Wierda WG, Abramson JS, Advani RH, Andreadis CB, Bartlett N, Byrd JC, Fayad LE, Fisher RI, Glenn MJ, Habermann TM, Lee Harris N, Hernandez-Ilizaliturri F, Hoppe RT, Kaminski MS, Kelsey CR, Kim YH, Krivacic S, LaCasce AS, Lunning M, Nademanee A, Press O, Rabinovitch R, Reddy N, Reid E, Roberts K, Saad AA, Sokol L, Swinnen LJ, Vose JM, Yahalom J, Zafar N, Dwyer M, Sundar H, Porcu P. NCCN Guidelines Insights: Non-Hodgkin’s Lymphomas, Version 3.2016. Journal of the National Comprehensive Cancer Network. 2016;14(9):1067-1079. https://doi.org/10.6004/jnccn.2016.0117
  48. Duvic M, Tetzlaff M, Gangar P, Clos A, Sui D, Talpur R. Results of a Phase II Trial of Brentuximab Vedotin for CD30+Cutaneous T-Cell Lymphoma and Lymphomatoid Papulosis. Journal of Clinical Oncology. 2015;33(32):3759-3765. https://doi.org/10.1200/jco.2014.60.3787
  49. Kim YH, Tavallaee M, Sundram U, Salva KA, Wood GS, Li S, Rozati S, Nagpal S, Krathen M, Reddy S, Hoppe RT, Nguyen-Lin A, Weng WK, Armstrong R, Pulitzer M, Advani RH, Horwitz SM. Phase II Investigator-Initiated Study of Brentuximab Vedotin in Mycosis Fungoides and Sézary Syndrome With Variable CD30 Expression Level: A Multi-Institution Collaborative Project. Journal of Clinical Oncology. 2015;33(32):3750-3758. https://doi.org/10.1200/jco.2014.60.3969
  50. Richardson K, Alrifai T, Grant-Szymanski K, Kouris GJ, Venugopal P, Mahon B, Karmali R. Breast implant-associated anaplastic large-cell lymphoma and the role of brentuximab vedotin (SGN-35) therapy: A case report and review of the literature. Mol Clin Oncol. 2017;6(4):539-542. https://doi.org/10.3892/mco.2017.1170
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