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Volkova Yu.I.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Zikiryakhodzhayev A.D.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia;
I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia;
Peoples’ Friendship University of Russia

Kazaryan L.P.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia;
I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia

Starkova M.V.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Maksimov K.V.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Volchenko N.N.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Biopsy of the sentinel lymph node and targeted axillary lymph node dissection in patients with breast cancer after neoadjuvant chemotherapy

Authors:

Volkova Yu.I., Zikiryakhodzhayev A.D., Kazaryan L.P., Starkova M.V., Maksimov K.V., Volchenko N.N.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2022;11(6): 44‑48

DOI: 10.17116/onkolog20221106144

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Table of contents

BIOPSY OF THE SENTINEL LYMPH NODE AND TARGETED AXILLARY LYMPH NODE DISSECTION IN PATIENTS WITH BREAST CANCER AFTER NEOADJUVANT CHEMOTHERAPY
BIOPSY OF THE SENTINEL LYMPH NODE AND TARGETED AXILLARY LYMPH NODE DISSECTION IN PATIENTS WITH BREAST CANCER AFTER NEOADJUVANT CHEMOTHERAPY

To cite this article:

Volkova YuI, Zikiryakhodzhayev AD, Kazaryan LP, Starkova MV, Maksimov KV, Volchenko NN. Biopsy of the sentinel lymph node and targeted axillary lymph node dissection in patients with breast cancer after neoadjuvant chemotherapy. P.A. Herzen Journal of Oncology. 2022;11(6):44‑48. (In Russ.)
https://doi.org/10.17116/onkolog20221106144

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)
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Abstract:

After neoadjuvant chemotherapy (NACT), patients with locally advanced breast cancer can show a complete morphopathological response not only in the breast, but also in the lymph nodes. There is now an ongoing discussion about the optimal volume of a surgical intervention in this category of patients. Targeted axillary dissection (TAD), a new technique, has been introduced in addition to axillary lymph node dissection and sentinel lymph node biopsy (SLNB). This paper provides an overview of the most important studies on the efficiency and safety of SLNB and TAD in patients after NACT.

Keywords:

locally advanced breast cancer
neoadjuvant chemotherapy
sentinel lymph node biopsy
targeted axillary dissection

Authors:

Volkova Yu.I.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Zikiryakhodzhayev A.D.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia;
I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia;
Peoples’ Friendship University of Russia

Kazaryan L.P.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia;
I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia

Starkova M.V.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Maksimov K.V.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Volchenko N.N.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Received:

18.05.2022

Accepted:

08.07.2022

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References:

  1. Fisher B, Redmond C, Poisson R, Margolese R, Wolmark N, Wickerham L, Fisher E, Deutsch M, Caplan R, Pilch Y, et al. Eight-year results of a randomized clinical trial comparing total mastectomy and lumpectomy with or without irradiation in the treatment of breast cancer. N Engl J Med. 1989;320(13):822-828.  https://doi.org/10.1056/NEJM198903303201302
  2. Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher ER, Jeong JH, Wolmark N. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347(16):1233-1241. https://doi.org/10.1056/NEJMoa022152
  3. Veronesi U, Saccozzi R, Del Vecchio M, Banfi A, Clemente C, De Lena M, Gallus G, Greco M, Luini A, Marubini E, et al. Comparing radical mastectomy with quadrantectomy, axillary dissection, and radiotherapy in patients with small cancers of the breast. N Engl J Med. 1981;305(1):6-11.  https://doi.org/10.1056/NEJM198107023050102
  4. Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini A, Aguilar M, Marubini E. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med. 2002;347(16):1227-1232. https://doi.org/10.1056/NEJMoa020989
  5. Lucci A, McCall LM, Beitsch PD, Whitworth PW, Reintgen DS, Blumencranz PW, Leitch AM, Saha S, Hunt KK, Giuliano AE; American College of Surgeons Oncology Group. Surgical complications associated with sentinel lymph node dissection (SLND) plus axillary lymph node dissection compared with SLND alone in the American College of Surgeons Oncology Group Trial Z0011. J Clin Oncol. 2007;25(24):3657-3663. https://doi.org/10.1200/JCO.2006.07.4062
  6. Giuliano AE, Ballman KV, McCall L, Beitsch PD, Brennan MB, Kelemen PR, Ollila DW, Hansen NM, Whitworth PW, Blumencranz PW, et al. Effect of axillary dissection vs no axillary dissection on 10-year overall survival among women with invasive breast cancer and sentinel node metastasis: the ACOSOG Z0011 (Alliance) randomized clinical trial. JAMA. 2017;318(10):918-926.  https://doi.org/10.1001/jama.2017.11470
  7. Kuehn T, Bauerfeind I, Fehm T, Fleige B, Hausschild M, Helms G, Lebeau A, Liedtke C, von Minckwitz G, Nekljudova V, et al. Sentinel-lymph-node biopsy in patients with breast cancer before and after neoadjuvant chemotherapy (SENTINA): a prospective, multicentre cohort study. Lancet Oncol. 2013;14(7):609-618.  https://doi.org/10.1016/S1470-2045(13)70166-9
  8. Boughey JC, Ballman KV, Le-Petross HT, McCall LM, Mittendorf EA, Ahrendt GM, Wilke LG, Taback B, Feliberti EC, Hunt KK, et al. Identification and resection of the clipped node decreases the false negative rate of sentinel lymph node surgery in patients presenting with node-positive breast cancer (T0-T4, N1-2) who receive neoadjuvant chemotherapy — results from ACOSOG Z1071 (Alliance). Ann Surg. 2016;263(4):802-807.  https://doi.org/10.1097/SLA.0000000000001375
  9. Enokido K, Watanabe C, Nakamura S, Ogiya A, Osako T, Akiyama F, Yoshimura A, Iwata H, Ohno S, Kojima Y, et al. Sentinel lymph node biopsy after neoadjuvant chemotherapy in patients with an initial diagnosis of cytology-proven lymph node-positive breast cancer. Clin Breast Cancer. 2016:16(4):299-304.  https://doi.org/10.1016/j.clbc.2016.02.009
  10. Bi Z, Liu J, Chen P, Liu Y, Zhao T, Wang C, Zhang Z, Sun X, Qiu P, Cong B, et al. Neoadjuvant chemotherapy and timing of sentinel lymph node biopsy in different molecular subtypes of breast cancer with clinically negative axilla. Breast Cancer. 2019;26(3):373-377.  https://doi.org/10.1007/s12282-018-00934-3
  11. Donker M, van Tienhoven G, Straver ME, Meijnen P, van de Velde CJ, Mansel RE, Cataliotti L, Westenberg AH, Klinkenbijl JH, Orzalesi L, et al. Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981-22023 AMAROS): a randomised, multicentre, open-label, phase 3 non-inferiority trial. Lancet Oncol. 2014;15(12):1303-1310. https://doi.org/10.1016/S1470-2045(14)70460-7
  12. Zetterlund LH, Frisell J, Zouzos A, Axelsson R, Hatschek T, de Boniface J, Celebioglu F. Swedish prospective multicenter trial evaluating sentinel lymph node biopsy after neoadjuvant systemic therapy in clinically node-positive breast cancer. Breast Cancer Res Treat. 2017;163(1):103-110.  https://doi.org/10.1007/s10549-017-4164-1
  13. Carrera D, de la Flor M, Galera J, Amillano K, Gomez M, Izquierdo V, Aguilar E, López S, Martínez M, Martínez S, et al. Validation of sentinel lymph node biopsy in breast cancer women N1—N2 with complete axillary response after neoadjuvant chemotherapy. Multicentre study in Tarragona. Rev Esp Med Nucl Imagen Mol. 2016;35(4):221-225.  https://doi.org/10.1016/j.remnie.2015.12.010
  14. Boileau JF, Poirier B, Basik M, Holloway CM, Gaboury L, Sideris L, Meterissian S, Arnaout A, Brackstone M, McCready DR, et al. Sentinel node biopsy after neoadjuvant chemotherapy in biopsy-proven node-positive breast cancer: the SN FNAC study. J Clin Oncol. 2015;33(3):258-264.  https://doi.org/10.1200/JCO.2014.55.7827
  15. Choy N, Lipson J, Porter C, Ozawa M, Kieryn A, Pal S, Kao J, Trinh L, Wheeler A, Ikeda D, et al. Initial results with preoperative tattooing of biopsied axillary lymph nodes and correlation to sentinel lymph nodes in breast cancer patients. Ann Surg Oncol. 2015;22(2):377-382.  https://doi.org/10.1245/s10434-014-4034-6
  16. Natsiopoulos I, Intzes S, Liappis T, Zarampoukas K, Zarampoukas T, Zacharopoulou V, Papazisis K. Axillary lymph node tattooing and targeted axillary dissection in breast cancer patients who presented as cN+ before neoadjuvant chemotherapy and became cN0 after treatment. Clin Breast Cancer. 2019;19(3):208-215.  https://doi.org/10.1016/j.clbc.2019.01.013
  17. Kanesalingam K, Sriram N, Heilat G, Ng EE, Meybodi F, Elder E, Brennan M, French J. Targeted axillary dissection after neoadjuvant systemic therapy in patients with node‐positive breast cancer. ANZ J Surg. 2020;90(3):332-338.  https://doi.org/10.1111/ans.15604
  18. Flores-Funes D, Aguilar-Jiménez J, Martínez-Gálvez M, Ibáñez-Ibáñez MJ, Carrasco-González L, Gil-Izquierdo JI, Chaves-Benito MA, Ayala-De La Peña F, Nieto-Olivares A, Aguayo-Albasini JL. Validation of the targeted axillary dissection technique in the axillary staging of breast cancer after neoadjuvant therapy: preliminary results. Surg Oncol. 2019;30:52-57.  https://doi.org/10.1016/j.suronc.2019.05.019
  19. Caudle AS, Yang WT, Krishnamurthy S, Mittendorf EA, Black DM, Gilcrease MZ, Bedrosian I, Hobbs BP, DeSnyder SM, Hwang RF, et al. Improved axillary evaluation following neoadjuvant therapy for patients with node-positive breast cancer using selective evaluation of clipped nodes: implementation of targeted axillary dissection. J Clin Oncol. 2016;34(10):1072-1078. https://doi.org/10.1200/JCO.2015.64.0094
  20. Donker M, Straver ME, Wesseling J, Loo CE, Schot M, Drukker CA, van Tinteren H, Sonke GS, Rutgers EJ, Vrancken Peeters MJ. Marking axillary lymph nodes with radioactive iodine seeds for axillary staging after neoadjuvant systemic treatment in breast cancer patients: the MARI procedure. Ann Surg. 2015;261(2):378-372.  https://doi.org/10.1097/SLA.0000000000000558
  21. Lee J, Jung JH, Kim W, Lee RK, Kim HJ, Kim WH, Park JY, Jeong JY, Chae YS, Lee SJ, et al. 5-year oncological outcomes of targeted axillary sampling in pT1-2N1 breast cancer. Asian J Surg. 2019;42(6):681-687.  https://doi.org/10.1016/j.asjsur.2018.10.004
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