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Pavlov A.Yu.

Russian Research Center of Roentgenology and Radiology of the Ministry of Health of Russia

Galushko D.A.

Russian Research Center of Roentgenology and Radiology of the Ministry of Health of Russia

Asmaryan H.G.

Russian Research Center of Roentgenology and Radiology of the Ministry of Health of Russia

Ukhvarkin A.P.

Russian Research Center of Roentgen and Radiology of the Ministry of Health of Russia

Features of multicentric cystic and solid parathyroid cancer with the development of hypercalcemic crisis and renal failure

Authors:

Pavlov A.Yu., Galushko D.A., Asmaryan H.G., Ukhvarkin A.P.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2021;10(3): 34‑42

DOI: 10.17116/onkolog20211003134

Read: 2247 times

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Table of contents

FEATURES OF MULTICENTRIC CYSTIC AND SOLID PARATHYROID CANCER WITH THE DEVELOPMENT OF HYPERCALCEMIC CRISIS AND RENAL FAILURE
FEATURES OF MULTICENTRIC CYSTIC AND SOLID PARATHYROID CANCER WITH THE DEVELOPMENT OF HYPERCALCEMIC CRISIS AND RENAL FAILURE

To cite this article:

Pavlov AYu, Galushko DA, Asmaryan HG, Ukhvarkin AP. Features of multicentric cystic and solid parathyroid cancer with the development of hypercalcemic crisis and renal failure. P.A. Herzen Journal of Oncology. 2021;10(3):34‑42. (In Russ.)
https://doi.org/10.17116/onkolog20211003134

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)
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Abstract:

Parathyroid cancer is one of the rarest malignant tumors. It is observed in 0.5-5% of patients with primary hyperparathyroidism and, in comparison with benign and non-neoplastic parathyroid diseases, is characterized by the higher serum levels of parathyroid hormone and calcium, which causes its aggressive and rapid course. Most patients die from uncontrolled severe hypercalcemia and kidney failure, not tumor spread. Surgical treatment is the only method that allows one to get rid of carcinoma itself and associated endocrine disorders. Parathyroid carcinoma has a high local recurrence rate, reaching 50%, but with relatively high long-term survival rates due to slow growth. The paper describes a clinical case of multicentric cystic and solid parathyroid cancer with the development of hypercalcemic crisis and renal failure.

Keywords:

parathyroid carcinoma
hyperparathyroidism
renal failure

Authors:

Pavlov A.Yu.

Russian Research Center of Roentgenology and Radiology of the Ministry of Health of Russia

Galushko D.A.

Russian Research Center of Roentgenology and Radiology of the Ministry of Health of Russia

Asmaryan H.G.

Russian Research Center of Roentgenology and Radiology of the Ministry of Health of Russia

Ukhvarkin A.P.

Russian Research Center of Roentgen and Radiology of the Ministry of Health of Russia

Received:

07.02.2021

Accepted:

16.03.2021

Close metadata

References:

  1. Kolsi N, Jellali S, Koubaa J. Parathyroid carcinoma: about a case and review of the literature. Pan Afr Med J. 2017;27:27-85.  https://doi.org/10.11604/pamj.2017.27.85.11584
  2. Valentina F, Lucia IS, Giovanna DM. Current concepts in parathyroid carcinoma: a single Centre experience. BMC Endocr Disord. 2019;19(suppl 1):46.  https://doi.org/10.1186/s12902-019-0368-1
  3. Sharretts JM, Kebebew E, Simonds WF. Parathyroid cancer. Semin Oncol. 2010;37(6):580-590.  https://doi.org/10.1053/j.seminoncol.2010.10.013
  4. Hundahl SA, Fleming ID, Fremgen AM, Menck HR. Two hundred eighty-six cases of parathyroid carcinoma treated in the U.S. between 1985—1995: a National Cancer Data Base Report. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer. 1999;86(3):538-544. https://doi.org/10.1002/(SICI)1097-0142(19990801)86:3<538::AID-CNCR25>3.0.CO;2-K "> 3.0.CO;2-K" target="_blank">https://doi.org/10.1002/(SICI)1097-0142(19990801)86:3<538::AID-CNCR25>3.0.CO;2-K
  5. Pyzik AJ, Matyjaszek-Matuszek B, Zwolak A, Chrapko B, Pyzik D, Strawa-Zakościelna K. Parathyroid cancer — difficult diagnosis — a case report. Nucl Med Rev Cent East Eur. 2016;19(1):46-50.  https://doi.org/10.5603/NMR.2016.0009
  6. de Quervain F. Parastruma maligna aberrata. Dtsch Z Chir. 1909;100:334-353.  https://doi.org/10.1007/BF02819737
  7. Sainton P, Millot J. Malegne d’un adenoma parathyroidiene eosinophile. Au cours d’une de Recklinghausen. Ann Anat Pathol. 1933;10:813-814. 
  8. Diaconescu MR, Glod M, Costea I, Grigorovici M, Diaconescu S. Clinicopathological phenotype of parathyroid carcinoma: therapeutic and prognostic aftermaths. Chirurgia (Bucur). 2015;110(1):66-71. 
  9. Machado NN, Wilhelm SM. Parathyroid cancer: A review. Cancers. 2019;11(11):1676. https://doi.org/10.3390/cancers11111676
  10. Marcocci C, Cetani F, Rubin MR, Silverberg SJ, Pinchera A, Bilezikian JP. Parathyroid carcinoma. J Bone Miner Res. 2008;23(12):1869-1880. https://doi.org/10.1359/jbmr.081018
  11. McMullen T, Bodie G, Gill A, Ihre-Lundgren C, Shun A, Bergin M, Stevens G, Delbridge L. Hyperparathyroidism after irradiation for childhood malignancy. Int J Radiat Oncol. 2009;73(4):1164-1168. https://doi.org/10.1016/j.ijrobp.2008.06.1487
  12. William F. Simonds, genetics of hyperparathyroidism, including parathyroid cancer. Endocrinol Metab Clin North Am. 2017;46(2):405-418.  https://doi.org/10.1016/j.ecl.2017.01.006
  13. Cardoso L, Stevenson M, Thakker RV. Molecular genetics of syndromic and non-syndromic forms of parathyroid carcinoma. Hum Mutat. 2017;38(12):1621-1648. https://doi.org/10.1002/humu.23337
  14. Quaglino F, Manfrino L, Cestino L, Giusti M, Mazza E, Piovesan A, Palestini N, Lauro C, Castellano E. Parathyroid carcinoma: An Up-to-Date retrospective multicentric analysis. Int J Endocrinol. 2020;2020:7048185. https://doi.org/10.1155/2020/7048185
  15. Mokrysheva NG. Pervichnyi giperparatireos. Epidemiologia, klinika, sovremennye printsipy diagnostiki i lecheniya: Dis. ... d-ra. med. nauk. M. 2011. (In Russ). https://www.dissercat.com/content/pervichnyi-giperparatireoz-epidemiologiya-klinika-sovremennye-printsipy-diagnostiki-i-lechen
  16. Akirov A, Asa SL, Larouche V, Mete O, Sawka AM, Jang R, Ezzat S. The clinicopathological spectrum of parathyroid carcinoma. Front Endocrinol. (Lausanne). 2019;10:731.  https://doi.org/10.3389/fendo.2019.00731
  17. Wang L, Han D, Chen W, Zhang S, Wang Z, Li K, Gao Y, Zou S, Yang A. Non-functional parathyroid carcinoma: A case report and review of the literature. Cancer Biol. Ther. 2015;16(11):1569-1576. https://doi.org/10.1080/15384047.2015.1070989
  18. Messerer CL, Bugis SP, Baliski C, Wiseman SM. Normocalcemic parathyroid carcinoma: An unusual clinical presentation. World J Surg Oncol. 2006;4:10.  https://doi.org/10.1186/1477-7819-4-10
  19. Wilhelm SM, Wang TS, Ruan DT, Lee JA, Asa SL, Duh QY, Doherty GM, Herrera MF, Pasieka JL, Perrier ND, Silverberg SJ, Solórzano CC, Sturgeon C, Tublin ME, Udelsman R, Carty SE. The American Association of Endocrine Surgeons Guidelines for definitive management of primary hyperparathyroidism. JAMA Surg. 2016;151(10):959-968.  https://doi.org/10.1001/jamasurg.2016.2310
  20. Lavely WC, Goetze S, Friedman KP, Leal JP, Zhang Z, Garret-Mayer E, Dackiw A, Tufano R, Zeiger M, Zeissman H. Comparison of SPECT/CT, SPECT, and planar imaging with single- and dual-phase (99m)Tc-sestamibi parathyroid scintigraphy. J Nucl Med. 2007;48(7):1084-1089. https://doi.org/10.2967/jnumed.107.040428
  21. Sidhu PS, Talat N, Patel P, Mulholland NJ, Schulte K-M. Ultrasound features of malignancy in the preoperative diagnosis of parathyroid cancer: A retrospective analysis of parathyroid tumours larger than 15 mm. Eur Radiol. 2011;21(9):1865-1873. https://doi.org/10.1007/s00330-011-2141-3
  22. Abboud B, Sleilaty G, Rabaa L, Daher R, Zeid HA, Jabbour H, Hachem K, Smayra T. Ultrasonography: highly accuracy technique for preoperative localization of parathyroid adenoma. Laryngoscope. 2008;118(9):1574-1578. https://doi.org/10.1097/MLG.0b013e31817aecad
  23. Weber AL, Randolph G, Aksoy FG. The thyroid and parathyroid glands. CT and MR imaging and correlation with pathology and clinical findings. Radiol Clin North Am. 2000;38(5):1105-1129. https://doi.org/10.1016/S0033-8389(05)70224-4
  24. Evangelista L, Sorgato N, Torresan F, Boschin IM, Pennelli G, Saladini G, Piotto A, Rubello D, Pelizzo MR. FDG-PET/CT and parathyroid carcinoma: Review of literature and illustrative case series. World J Clin Oncol. 2011;2(10):348-354.  https://doi.org/10.5306/wjco.v2.i10.348
  25. Bancos I, Grant C, Nadeem S, Stan M, Reading C, Sebo T, Algeciras-Simnich A, Singh R, Dean D. Risks and benefits of parathyroid fine-needle aspiration with parathyroid hormone washout. Endocr Pract. 2012;18(4):441-449.  https://doi.org/10.4158/EP11148.OR
  26. Long KL, Sippel RS. Current and future treatments for parathyroid carcinoma. Int J Endocr Oncol. 2018;5:IJE06. https://doi.org/10.2217/ije-2017-0011
  27. Amin MB, Edge S, Greene F, Byrd DR, Brookland RK, et al, eds. AJCC cancer staging manual. 8th ed. Springer;2017;ch75:903-910. 
  28. Hoelting T, Weber T, Werner J, Herfarth C. Surgical treatment of parathyroid carcinoma. Oncol Rep. 2001;8(4):931-934.  https://doi.org/10.3892/or.8.4.931
  29. Sahasranam P, Tran MT, Mohamed H, Friedman TC. Multiglandular parathyroid carcinoma: A case report and brief review. South Med J. 2007;100:841-844.  https://doi.org/10.1097/SMJ.0b013e318073ca37
  30. Schulte K-M, Gill AJ, Barczynski M, Karakas E, Miyauchi A, Knoefel WT, Lombardi CP, Talat N, Diaz-Cano S, Grant CS. Classification of parathyroid cancer. Ann Surg Oncol. 2012;19(8):2620-2628. https://doi.org/10.1245/s10434-012-2306-6
  31. Hsu K-T, Sippel RS, Chen H, Schneider DF. Is central lymph node dissection necessary for parathyroid carcinoma? Surgery. 2014;156(6):1336-1341. https://doi.org/10.1016/j.surg.2014.08.005
  32. Koea JB, Shaw JH. Parathyroid cancer: biology and management. Surg Oncol. 1999;8(3):155-165.  https://doi.org/10.1016/s0960-7404(99)00037-7
  33. Schulte K-M, Talat N, Miell J, Moniz C, Sinha P, Diaz-Cano S. Lymph node involvement and surgical approach in parathyroid cancer. World J Surg. 2010;34(11):2611-2620. https://doi.org/10.1007/s00268-010-0722-y
  34. Rodgers SE, Perrier ND. Parathyroid carcinoma. Curr Opin Oncol. 2006;18:16-22.  https://doi.org/10.1097/01.cco.0000198019.53606.2b
  35. Asare EA, Sturgeon C, Winchester DJ, Liu L, Palis B, Perrier ND, Evans D, Winchester D, Wang T. Parathyroid carcinoma: An update on treatment outcomes and prognostic factors from the National Cancer Data Base (NCDB). Ann Surg Oncol. 2015;22(12):3990-3995. https://doi.org/10.1245/s10434-015-4672-3
  36. Kebebew E, Arici C, Duh QY, Clark OH. Localization and reoperation results for persistent and recurrent parathyroid carcinoma. Arch Surg. 2001;136(8):878-885.  https://doi.org/10.1001/archsurg.136.8.878
  37. Li Y, Simonds WF. Endocrine neoplasms in familial syndromes of hyperparathyroidism. Endocr Relat Cancer. 2016;23(6):229-247.  https://doi.org/10.1530/ERC-16-0059
  38. Mezhir JJ, Melis M, Headley RC, Pai RK, Posner MC, Kaplan EL. Successful palliation of hypercalcemia secondary to metastatic parathyroid cancer: an unusual indication for hepatic resection. J Hepatobiliary Pancreat Surg. 2007;14(4):410-411.  https://doi.org/10.1007/s00534-006-1173-6
  39. Erovic BM, Goldstein DP, Kim D, Mete O, Brierley J, Tsang R, Freeman JL, Asa SL, Rotstein L, Irish JC. Parathyroid cancer: outcome analysis of 16 patients treated at the Princess Margaret Hospital. Head Neck. 2013;35(1):35-39.  https://doi.org/10.1002/hed.22908
  40. Owen RP, Silver CE, Pellitteri PK, Shaha AR, Devaney KO, Werner JA, Rinaldo A, Ferlito A. Parathyroid carcinoma: a review. Head Neck. 2011;33(3):429-436.  https://doi.org/10.1002/hed.21376
  41. Shane E. Parathyroid carcinoma. J Clin Endocrinol Metab. 2001;86(2):485-493.  https://doi.org/10.1210/jcem.86.2.7207
  42. Mittendorf EA, McHenry CR. Parathyroid carcinoma. J Surg Oncol. 2005; 89(3):136-142.  https://doi.org/10.1002/jso.20182
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