Prevention and correction of anthracycline-induced angiopathy: an experimental study

Valeev V.V.

I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg, Russia

Trashkov A.P.

St. Petersburg State Pediatric Medical University, St. Petersburg

Kovalenko A.L.

Direktsiia po nauke OOO "NTFF "Polisan", Sankt-Peterburg

Petrov A.Yu.

I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg, Russia

Vasiliev A.G.

St. Petersburg State Pediatric Medical University, St. Petersburg

Prevention and correction of anthracycline-induced angiopathy: an experimental study

Authors:

Valeev V.V., Trashkov A.P., Kovalenko A.L., Petrov A.Yu., Vasiliev A.G.

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Journal: P.A. Herzen Journal of Oncology. 2016;5(6): 31‑34

DOI: 10.17116/onkolog20165631-34

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To cite this article:

Valeev VV, Trashkov AP, Kovalenko AL, Petrov AYu, Vasiliev AG. Prevention and correction of anthracycline-induced angiopathy: an experimental study. P.A. Herzen Journal of Oncology. 2016;5(6):31‑34. (In Russ.)
https://doi.org/10.17116/onkolog20165631-34

Подписка 2025-2 (P.A. Herzen Journal of Oncology)

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Objective: to evaluate the angioprotective effect of sodium L-arginine succinate (Unifusol, «POLYSAN», Russia) in acute doxorubicin intoxication in the experiment. Material and methods. The efficacy of the drug was evaluated by its effect on the balance between vasodilators and vasoconstrictors, the ratio of pro- to anti-inflammatory cytokines, and the degree of endothelial cell apoptosis. Results. Sodium L-arginine succinate was shown to improve endothelium-dependent vasodilation and to reduce the degree of doxorubicin-induced systemic inflammatory manifestations. Conclusion. The pronounced endothelioprotective effect of the test drug is a pathogenetic rationale for further investigation of Unifusol as a complex agent for cardio- and angioprotection in cardiovascular diseases of various etiologies.

Keywords:

arginine

doxorubicin

sodium L-arginine succinate

anthracycline-induced angiopathy

endothelial dysfunction

endothelial markers

Unifusol

Authors:

Valeev V.V.

I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg, Russia

Trashkov A.P.

St. Petersburg State Pediatric Medical University, St. Petersburg

Kovalenko A.L.

Direktsiia po nauke OOO "NTFF "Polisan", Sankt-Peterburg

Petrov A.Yu.

I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg, Russia

Vasiliev A.G.

St. Petersburg State Pediatric Medical University, St. Petersburg

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