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Borodina T.N.

Federal Scientific Research Centre «Crystallography and Photonics» of Russian Academy of Sciences

Tolordava E.R.

N.F. Gamaleya National Research Center

Nikolaeva M.E.

MIREA — Russian Technological University

Solovyev A.I.

S.M. Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation

Romanova Yu.M.

N.F. Gamaleya Federal research Center for Epidemiology and Microbiology of the Ministry of Public Health of Russia

Khaydukov E.V.

Federal Scientific Research Centre «Crystallography and Photonics» of Russian Academy of Sciences

Panchenko V.Ya.

Federal Scientific Research Centre «Crystallography and Photonics» of Russian Academy of Sciences

Antimicrobial photodynamic activity of hydrophilic riboflavin derivatives

Authors:

Borodina T.N., Tolordava E.R., Nikolaeva M.E., Solovyev A.I., Romanova Yu.M., Khaydukov E.V., Panchenko V.Ya.

More about the authors

Journal: Molecular Genetics, Microbiology and Virology. 2021;39(4): 21‑26

DOI: 10.17116/molgen20213904121

Read: 1557 times

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Table of contents

ANTIMICROBIAL PHOTODYNAMIC ACTIVITY OF HYDROPHILIC RIBOFLAVIN DERIVATIVES
ANTIMICROBIAL PHOTODYNAMIC ACTIVITY OF HYDROPHILIC RIBOFLAVIN DERIVATIVES

To cite this article:

Borodina TN, Tolordava ER, Nikolaeva ME, Solovyev AI, Romanova YuM, Khaydukov EV, Panchenko VYa. Antimicrobial photodynamic activity of hydrophilic riboflavin derivatives. Molecular Genetics, Microbiology and Virology. 2021;39(4):21‑26. (In Russ.)
https://doi.org/10.17116/molgen20213904121

Подписка 2026 Молекулярная генетика, микробиология и вирусология (Molecular Genetics, Microbiology and Virology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

THE AIM OF THIS WORK

To investigate the antibacterial and antiviral properties of the riboflavin derivative (Vitamin B2) — flavin mononucleotide and its derivative synthesized by conjugation with polyethylene glycol (Rf-PEG).

MATERIALS AND METHODS

Flavin mononucleotide and a conjugate of riboflavin with polyethylene glycol were investigated. Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Salmonella typhimurium were used as clinical isolates.

RESULTS

With the growing number of antibiotic-resistant microorganisms, it is necessary to search for new strategies aimed at inactivating pathogens and preventing the development of their drug resistance. Antimicrobial photodynamic therapy (aPDT) is a promising approach to inactivate pathogens regardless of their antibiotic resistance status. The work investigated the antibacterial and antiviral properties of the derivative of riboflavin (Vitamin B2) — flavin mononucleotide and its derivative synthesized by conjugation with polyethylene glycol (Rf-PEG).

CONCLUSION

It has been shown that hydrophilic riboflavin derivatives are effective photosensitizers and provide inactivation of both gram-positive and gram-negative microorganisms during aPDT in vitro.

Keywords:

pathogenic microorganisms
antimicrobial photodynamic therapy
photosensitizer
riboflavin

Authors:

Borodina T.N.

Federal Scientific Research Centre «Crystallography and Photonics» of Russian Academy of Sciences

Tolordava E.R.

N.F. Gamaleya National Research Center

Nikolaeva M.E.

MIREA — Russian Technological University

Solovyev A.I.

S.M. Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation

Romanova Yu.M.

N.F. Gamaleya Federal research Center for Epidemiology and Microbiology of the Ministry of Public Health of Russia

Khaydukov E.V.

Federal Scientific Research Centre «Crystallography and Photonics» of Russian Academy of Sciences

Panchenko V.Ya.

Federal Scientific Research Centre «Crystallography and Photonics» of Russian Academy of Sciences

Received:

03.09.2021

Accepted:

30.09.2021

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References:

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