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Kaprin A.D.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of Ministry of Russia;
Peoples’ Friendship University of Russia

Ivanov S.A.

Tsyb Medical Radiology Research Center

Petrov L.O.

National Medical Research Center for Radiology

Kucherov V.V.

A.F. Tsyb Medical Radiology Research Center — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Pobedintseva Yu.A.

Kostroma Oncology Dispensary

Filimonov E.V.

Kostroma Oncology Dispensary

Kruglov E.A.

Kostroma Oncology Dispensary

Petrosyan A.P.

Blokhin National Medical Cancer Research Center

Nazarova V.V.

Blokhin National Cancer Research Center

Unguryan V.M.

Kostroma Oncology Center

Transarterial chemoembolization and isolated liver chemoperfusion in the treatment of uveal melanoma in patients with liver metastases (a systematic review)

Authors:

Kaprin A.D., Ivanov S.A., Petrov L.O., Kucherov V.V., Pobedintseva Yu.A., Filimonov E.V., Kruglov E.A., Petrosyan A.P., Nazarova V.V., Unguryan V.M.

More about the authors

Journal: Medical Technologies. Assessment and Choice. 2022;44(2): 72‑79

DOI: 10.17116/medtech20224402172

Views: 1549

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To cite this article:

Kaprin AD, Ivanov SA, Petrov LO, et al. . Transarterial chemoembolization and isolated liver chemoperfusion in the treatment of uveal melanoma in patients with liver metastases (a systematic review). Medical Technologies. Assessment and Choice. 2022;44(2):72‑79. (In Russ.)
https://doi.org/10.17116/medtech20224402172

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OBJECTIVE

To analyze safety, immediate and long-term results of transarterial chemoembolization and isolated liver chemoperfusion in patients with liver metastases of uveal melanoma.

MATERIAL AND METHODS

Searching for literature data (PubMed, eLibrary, Cochrane Library databases) was carried out in accordance with the PRISMA 2020 recommendations (checklist and flowchart). Seven studies were selected. Selection criteria: liver metastases of uveal melanoma, transarterial chemoembolization, isolated liver chemoperfusion. The endpoints were postoperative mortality, objective response rate, overall survival and recurrence-free survival. In all studies, these parameters were analyzed using Kaplan-Meier method.

RESULTS

Objective response rate, overall and recurrence-free survival were significantly higher after isolated liver chemoperfusion. At the same time, incidence of complications and postoperative mortality were significantly lower after transarterial chemoembolization.

CONCLUSION

Isolated chemoperfusion is a perspective method in the treatment of patients with liver metastases of uveal melanoma. Minimally invasive technique of isolated liver perfusion may be effective to reduce the incidence of postoperative complications and mortality.

Keywords:

uveal melanoma
liver metastases
transarterial chemoembolization
isolated liver chemoperfusion

Authors:

Kaprin A.D.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of Ministry of Russia;
Peoples’ Friendship University of Russia

Ivanov S.A.

Tsyb Medical Radiology Research Center

Petrov L.O.

National Medical Research Center for Radiology

Kucherov V.V.

A.F. Tsyb Medical Radiology Research Center — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Pobedintseva Yu.A.

Kostroma Oncology Dispensary

Filimonov E.V.

Kostroma Oncology Dispensary

Kruglov E.A.

Kostroma Oncology Dispensary

Petrosyan A.P.

Blokhin National Medical Cancer Research Center

Nazarova V.V.

Blokhin National Cancer Research Center

Unguryan V.M.

Kostroma Oncology Center

Received:

07.02.2022

Accepted:

05.03.2022

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