PURPOSE
To compare integral tests (thrombin generation test, thromboelastometry, thrombodynamic test) in patients with COVID-19 of varying severity.
MATERIALS AND METHODS
The study included 141 patients with a confirmed diagnosis of COVID-19. Patients were divided according to severity into 3 groups: 1 mild course (n=39), 2 moderate course (n=65), 3 severe course (n=37). In group 1 (outpatient treatment), the first blood sampling for the study was on the 3rd—7th day of illness (point 1), and the second — after recovery (in 14—28 days) (point 2); group 2 and 3 — on the day of admission to the hospital (point 1) and 14 days later (point 2). In the dynamics of treatment in patients, the parameters of thromboelastometry, thrombodynamic test and thrombin generation test were evaluated. The level of heparin in the blood was determined on an automatic coagulometer ACL TOP 700 (Instrumentation Laboratory, USA).
RESULTS
It was noted that male gender, older age, overweight and obesity were an unconditional risk factor for the severity of COVID-19. Differences for structural parameters (A10, A20, MCF) in thromboelastometry were found for 3 groups of patients at the 1st point. Hypercoagulability was noted only in the group with severe COVID-19 at the onset of the disease. For thrombodynamic parameters (V, Vst, Vi, CS, D) in 3 groups, a significant decrease was found in the 2nd (at the end of treatment) point compared to the 1st (at the beginning of treatment). When comparing the parameters of the thrombin generation test at the beginning and at the end of treatment, significant changes were found for the Cmax parameter in the group with a mild course of the disease. The relationship between thrombodynamic parameters and the level of antiXa activity was revealed.
CONCLUSIONS
The results of integral tests (thrombin generation test, thromboelastometry, thrombodynamics test) show similar dynamics of recovery: normalization of hemostasis parameters during convalescence in patients with COVID-19 virus infection of varying severity.
