HPV infection of the male urogenital tract: is there aa association with infertility and chronic prostatitis?

Kovalyk V.P.; Gomberg M.A.; Vladimirova E.V.; Yurlov K.I.; Kushch A.A.

doi:https://doi.org/10.17116/klinderma202322031296

Kovalyk V.P.

Academy of postgraduate education under Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of Russia;
Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

ORCID: 0000-0002-0453-2771

Gomberg M.A.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

ORCID: 0000-0002-1070-5229

Vladimirova E.V.

Academy of postgraduate education under Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of Russia

ORCID: 0000-0002-4123-4204

Yurlov K.I.

N.F. Gamaleya Federal Research Centre of Epidemiology and Microbiology

ORCID: 0000-0002-4694-2445

Kushch A.A.

N.F. Gamaleya Federal Research Centre of Epidemiology and Microbiology

ORCID: 0000-0002-3396-5533

HPV infection of the male urogenital tract: is there aa association with infertility and chronic prostatitis?

Authors:

Kovalyk V.P., Gomberg M.A., Vladimirova E.V., Yurlov K.I., Kushch A.A.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2023;22(3): 296‑301

DOI: 10.17116/klinderma202322031296

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To cite this article:

Kovalyk VP, Gomberg MA, Vladimirova EV, Yurlov KI, Kushch AA. HPV infection of the male urogenital tract: is there aa association with infertility and chronic prostatitis? Russian Journal of Clinical Dermatology and Venereology. 2023;22(3):296‑301. (In Russ.)
https://doi.org/10.17116/klinderma202322031296

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)

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INTRODUCTION

The role of human papilloma viruses is well-studied in a number of cancers. However, the role of urogenital HPV infection and its association with pathospermia, male infertility, and genitourinary tract inflammatory diseases are understudied. Objective. To determine the prevalence of HPV in patients with chronic prostatitis and infertility.

MATERIALS AND METHODS

Quantitative PCR was used to detect high carcinogenic risk (HCR) HPV in the ejaculate of 489 males aged 22–65. Group 1 included infertile males with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), Group 2 included males with idiopathic infertility (without CP/CPPS), Group 3 included fertile males with CP/CPPS, Group 4 included healthy fertile males (control group).

RESULTS

64 (14.6%) of the examined males had HPV. None of the males from the control group had HCR HPV in the ejaculate. Group 1 had a significantly higher number of all HPV genotypes (40 (22.2%) of 180) than Group 2 (25 (14.3%) of 175) and Group 3 (13 (15.9%) of 82). HPV viral load was highest in Group 3 (~2500 copies/100.000 cells).

CONCLUSION

HCR HPV is associated with male infertility and chronic prostatitis/chronic pelvic pain syndrome. The association of mixed infection with various HPV types with infertility and high HPV viral load with CP/CPPS was shown.

Keywords:

HPV of high carcinogenic risk

male infertility

chronic prostatitis

Authors:

Kovalyk V.P.

ORCID: 0000-0002-0453-2771

Gomberg M.A.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

ORCID: 0000-0002-1070-5229

Vladimirova E.V.

Academy of postgraduate education under Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of Russia

ORCID: 0000-0002-4123-4204

Yurlov K.I.

N.F. Gamaleya Federal Research Centre of Epidemiology and Microbiology

ORCID: 0000-0002-4694-2445

Kushch A.A.

N.F. Gamaleya Federal Research Centre of Epidemiology and Microbiology

ORCID: 0000-0002-3396-5533

Received:

21.02.2023

Accepted:

24.03.2023

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References:

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