The relevance of patients’ management with long-term healing wounds and ulcers is beyond doubt. Poor nutrition, a sedentary lifestyle, a deteriorating environment, an increasing life expectancy of the population cause the development of a large number of somatic diseases (oncological and neurodegenerative diseases, diabetes mellitus, obesity, etc.), resulting that infectious skin diseases becomes chronic and often non-responsive to ongoing therapy. An ulcer is a defect in the skin or mucous membrane, which is characterized by a chronic course without a tendency to spontaneous healing, or periodic recurrence of the disease. An integrated approach to managing patients with chronic wounds and ulcers has been successfully applied in clinical practice. The wound process is a complex of local and general biological reactions of tissues and body systems, aimed at delimiting and rejecting necrotic masses, fighting infection, restoring and replacing damaged structures. The infectious process is the process of the introduction and development of microorganisms in habitats unusual for them (tissues, internal cavities and organs) with the subsequent development of complex interactions between macro- and microorganisms.