Prurigo refers to neurodermatosis and is clinically manifested in three forms: prurigo infantum (strofulus), prurigo adultorum and prurigo nodularis of Hyde (nodular prurigo). Hyde prurigo nodularis is the rarest clinical form of prurigo, characterized by lichenoid, severely itchy papules and nodes mainly on the skin of the limbs, as well as a long, persistent course. In children and teenagers, this form is extremely rare. Described a case of a Hyde prurigo nodularis, complicated by pyoderma, in a 13-year-old adolescent. The pathological process was localized on the skin of the face, trunk, inguinal folds, buttocks, upper and lower extremities and was represented by itchy papules, single nodes and individual erythematous-squamous foci, as well as excoriations covered with serous-hemorrhagic and purulent crusts. In addition, on the back surface of the right lower leg above the skin was towered an infiltrative fluctuating foci 3 cm in diameter, painful on palpation. Upon consultation with the surgeon, a diagnosis of abscess of the right lower leg was confirmed. Comprehensive treatment included intravenous drip of 0.9% sodium chloride solution, intramuscular injection of 10% calcium gluconate solution (No. 11), chloropyramine (No. 10), ceftriaxone (No. 10) and betaspan depo (once), the total medium-wave UV-, UHF-therapy on the abscess area, as well as the use of external drugs: 1% aqueous solution of methylene blue, 5% DAS paste, betamethasone genta cream, on the abscess area — a solution of dioxidine and baneocin powder. After treatment, itching decreased, rashes were partially resolved, regression of an abscess on the right lower leg, complete rejection of the crusts followed by the development of post-inflammatory hypopigmentation were noted.