Corneometry was used to assess skin hydration in 50 healthy volunteers aged 18 to 35 years. The initial skin hydration was determined in 5 areas of the back surface of the brush. Re-hydration of the skin was evaluated after 30 and 90 minutes after contact with water in one area without applying cream and in 4 areas after applying emollients: emollient 1 — cream containing 7% ectoine, as well as hydrogenated lecithin, ceramide-3; emollient 2 — a cream containing micronized colloidal pulp, avenantramides, ceramides; emollient 3 — balm containing 20% Shea butter, Canola oil enriched with omega-3 and -6 fatty acids, niacinamide 4% and the active component that normalizes skin microbiome; emollient 4 — lotion containing a complex of filaggrin derivatives with prekeramides and vitamin B3. A cream containing 7% ectoine showed an effect comparable to that used in clinical practice emollients on the indicators of skin hydration, measured by the method of corneometry. The features of this cream can be considered a longer duration of the moisturizing effect (only in 1 out of 50 cases, 90 minutes after application of the drug, significant dry skin was observed), as well as the ability to moisturize the skin well after a single application, which was not found in all of the considered emollients. This effect was completely absent in areas of the skin without applying a moisturizer.