The main link in the treatment of atopic dermatitis in children is an external therapy aimed at relieving inflammation, itching, increasing the barrier function of the skin and normalizing the psycho-emotional state of the child. Objective — the study of efficacy and safety of integrated application non-halogenated topical glucocorticosteroid and local immunomodulator for the treatment of atopic dermatitis in children. Material and methods. 30 children aged from 2 to 12 years with the acute stage of moderate and severe atopic dermatitis were under observation. Standard systemic therapy and locally — step therapy were prescribed: methylprednisolone aceponate with ceramides once a day for five days, followed by tacrolimus — calcineurin inhibitor 0.03% twice a day for two weeks. Evaluation of therapy was carried out before treatment, two and four weeks from its beginning using the SCORAD index, the CDLQI questionnaire, skin moisture level in the lesions. Results. Complex treatment, including consistent use of these drugs in children with atopic dermatitis, is a highly effective method, as evidenced by the reduction of SCORAD indices 4.3 times (p<0.01) (61.7 and 14.2 points), CDLQI — 2.9 times (21.1 and 7.3 points) (p<0.05), an increase in the corneometry index 2.6 times (18.2 and 47.1 units) (p<0.05). Conclusion. The result of complex treatment of moderate and severe atopic dermatitis with sequential use of these drugs was a positive transformation of the clinical picture of the disease.