Assessing the effect of immunotropic agents on microbiological contamination of the skin in patients with pyoderma

Vislobokov A.V.; Mel`nikova E.F.; Khmel`nitskiy R.A.

doi:https://doi.org/10.17116/klinderma201716110-15

Vislobokov A.V.

Meditsinskij institut Orlovskogo gosudarstvennogo universiteta im. I.S. Turgeneva, Orel, Rossija, 302026

Mel`nikova E.F.

Meditsinskij institut Orlovskogo gosudarstvennogo universiteta im. I.S. Turgeneva, Orel, Rossija, 302026

Khmel`nitskiy R.A.

FGBOU VPO «Kurskij gosudarstvennyj meditsinskij universitet», Kursk, Rossija, 305000

Assessing the effect of immunotropic agents on microbiological contamination of the skin in patients with pyoderma

Authors:

Vislobokov A.V., Mel`nikova E.F., Khmel`nitskiy R.A.

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Journal: Russian Journal of Clinical Dermatology and Venereology. 2017;16(1): 10‑15

DOI: 10.17116/klinderma201716110-15

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To cite this article:

Vislobokov AV, Mel`nikova EF, Khmel`nitskiy RA. Assessing the effect of immunotropic agents on microbiological contamination of the skin in patients with pyoderma. Russian Journal of Clinical Dermatology and Venereology. 2017;16(1):10‑15. (In Russ.)
https://doi.org/10.17116/klinderma201716110-15

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)

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Abstract:

Objective — the study was aimed at providing clinical rationale for the use of natural immunomodulators in treatment of patients with skin and soft tissue infections. Material and methods. Patients were divided into three groups: group 1 patients (n=35) were administered with antibiotic therapy in combination with the peptide, comprising immunoactive signaling molecules; group 2 patients (n=36) received a combination that included immunomodulator, which is an analogue of muramyl dipeptide, a peptidoglycan from the bacterial cell wall. Group 3 patients (n=36) received only antimicrobial therapy. Results. Treatment with immune agents showed high clinical efficacy. Administration of immunoactive drugs was associated with significant inhibition of pathogenic microflora growth and fivefold decrease in CFU/ml. Conclusion. Glucosaminylmuramyl dipeptide is the most effective immunomodulating agent in the complex treatment of chronic and complicated forms of pyoderma.

Keywords:

pyoderma

immunomodulators

treatment

microbiological contamination

Authors:

Vislobokov A.V.

Meditsinskij institut Orlovskogo gosudarstvennogo universiteta im. I.S. Turgeneva, Orel, Rossija, 302026

Mel`nikova E.F.

Meditsinskij institut Orlovskogo gosudarstvennogo universiteta im. I.S. Turgeneva, Orel, Rossija, 302026

Khmel`nitskiy R.A.

FGBOU VPO «Kurskij gosudarstvennyj meditsinskij universitet», Kursk, Rossija, 305000

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