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Chernova N.I.

Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet im. A.I. Evdokimova

Bagaeva M.I.

Kafedra akusherstva i ginekologii Rossiĭskoĭ gosudarstvennoĭ meditsinskoĭ akademii poslediplomnogo obrazovaniia, Moskva

Stovbun S.V.

Institut khimicheskoĭ fiziki im. N.N. Semenova RAN, Moskva

Sci Dr.

N.N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia

Kucherov A.V.

FGBUN «Institut himicheskoj fiziki im. N.N. Semenova» RAN, Moskva, Rossija, 119991, OOO «Lihvinskie vody», Tul'skaja obl., pos. Rozhdestveno, Rossija

Experience in management of patients with lichen sclerosus and HPV infection of the vulva

Authors:

Chernova N.I., Bagaeva M.I., Stovbun S.V., Sci Dr., Kucherov A.V.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2016;15(5): 72‑76

DOI: 10.17116/klinderma201615572-76

Views: 3824

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To cite this article:

Chernova NI, Bagaeva MI, Stovbun SV, Sci Dr, Kucherov AV. Experience in management of patients with lichen sclerosus and HPV infection of the vulva. Russian Journal of Clinical Dermatology and Venereology. 2016;15(5):72‑76. (In Russ.)
https://doi.org/10.17116/klinderma201615572-76

 
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This problem is relevant due to increased number of patients with lichen sclerosus of the vulva and the complexity of disease control. Objective. The study is aimed at improving treatment of lichen sclerosus accompanied by co-infections, using Panavir, platelet-rich autoplasma obtained using Swiss technology RegenLab, and exposure of affected area to infrared laser radiation. Material and methods. The study included 40 females diagnosed with lichen sclerosus of the vulva. All patients underwent outpatient complex therapy with platelet-rich autoplasma obtained using Swiss technology RegenLab and exposure of affected area to infrared laser radiation with Panavir gel. Treatment course included 10 sessions (on a daily basis). A total of 2—3 courses have been carried out with 4-week-long intervals. Results. Combination therapy using platelet-rich autoplasma, infrared laser radiation, and Panavir gel for external and topical application in patients with early signs of lichen sclerosus was effective in 90% of cases.

Keywords:

lichen sclerosus
vulva
urogenital tract infections
low-intensity laser radiation
PRP
collagenesis
Panavir
antiviral activity
repair

Authors:

Chernova N.I.

Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet im. A.I. Evdokimova

Bagaeva M.I.

Kafedra akusherstva i ginekologii Rossiĭskoĭ gosudarstvennoĭ meditsinskoĭ akademii poslediplomnogo obrazovaniia, Moskva

Stovbun S.V.

Institut khimicheskoĭ fiziki im. N.N. Semenova RAN, Moskva

Sci Dr.

N.N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia

Kucherov A.V.

FGBUN «Institut himicheskoj fiziki im. N.N. Semenova» RAN, Moskva, Rossija, 119991, OOO «Lihvinskie vody», Tul'skaja obl., pos. Rozhdestveno, Rossija

List of references:

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  2. Levis FM. Vulva disease from the 1800s to the new millennium. J Cutan Med Surg. 2002;6(4):340-344.
  3. Micheletti L, Preti M, Bogliatto F, Lynch PJ. Vulvology: a proposal for a multidisciplinary subspecialty. J Reprod Med. 2002;47:715-717.
  4. Lynch PJ, Moyal-Barracco M, Scurry J, Stockdale C. Terminology and Classification of Vulvar Dermatological Disorders: an approach to clinical diagnosis. J Lower Gen Tract Dis. 2012.
  5. Manukhin IB, Kondrikov NI, Kraposhina TP. Zabolevaniya naruzhnykh polovykh organov u zhenshchin. Moscow: MIA. 2002. (In Russ)
  6. Kaufman R, Faro S, Braun D. Dobrokachestvennye zabolevaniya vul'vy i vlagalishcha. Moscow. 2009;320–343. (In Russ)
  7. Powell JJ, Wojnarowska F. Chilhood vulvar lichen sclerosus:an increasingly common problem. J Am Acad Dermatol. 2001;44(5):803–806.
  8. Markina EI. Rol' infektsionnykh faktorov i gormonal'nykh narusheniy v geneze distroficheskikh zabolevaniy vul'vy i ikh kompleksnoe lechenie. Candidate of medicine thesis. Moscow. 2003. (In Russ)
  9. Stucker M, Grape J, Bechara FG, et al. The outcome after cryosurgery and intralesional steroid injection in vulvar lichen sclerosus corresponds to preoperative histopathological findings. Dermatology. 2005;210:3:218–222.
  10. Broneshter D.Sh. Lechenie distroficheskikh protsessov vul'vy s pomoshch'yu IK-lazernogo izlucheniya. Candidate of medicine thesis: Moscow. 1991. (In Russ)
  11. Clinical guidelines of the Russian Society of Dermatologists, Venereologists and Cosmetologists. Moscow. 2015. (In Russ)
  12. Marx R. Platelet-reach plasma (PRP): what is PRP and what is not PRP? Implant dentistry. 2001;10(4):121–125.
  13. Marx R, Carlson T, Eichstaedt R, Schimmele S, Struss J. Platelet- reach plasma: growth factor enhancement for bone grafts. Oral Surgery, Oral Medicine, Oral Pathology. 1998;85(6):6438–6446.
  14. Achkasov EE, Bezuglov EN, Ul'yanov AA. et al. Application of platelet-rich autoplasma in clinical practice. Biomeditsina. 2013; 4: 46–59. (In Russ)

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