Autoimmune pemphigus belongs to the group of autoimmune bullous dermatoses where the etiopathogenetic role is played by circulating autoantibodies against the antigens of the desmosomal apparatus of the stratified squamous epithelium. The presence of HLA haptotypes suggests that the organism is genetically predisposed to this disease. However, additional factors contributing to the development of the immunopathological process are required for pemphigus. The performed investigation indicates that the occurrence and further course of pemphigus are favored by at least two provoking factors, among which there must be psychoemotional overstress. Other additional pathogenic factors are most commonly drugs, hyperinsolation, and contact with chemicals. At the same time the drugs are involved mainly in the development of pemphigus vulgaris and insolation is responsible for pemphigus seborrhea or foliaceus.