Synchronous primary multiple cancer: distal cholangiocarcinoma of the intrapancreatic common bile duct and intraductal papillary mucinous tumor associated with ductal adenocarcinoma of the pancreatic tail

Setdikova G.R.; Stepanova E.A.; Verbovsky A.N.; Semenkov A.V.

doi:https://doi.org/10.17116/hirurgia202408157

Setdikova G.R.

Vladimirsky Moscow Regional Research Clinical Institute

ORCID: 0000-0002-5262-4953

Stepanova E.A.

M.F. Vladimirsky Moscow Regional Clinical Research Institute

ORCID: 0000-0002-9037-0034

Verbovsky A.N.

Vladimirsky Moscow Regional Research Clinical Institute

ORCID: 0000-0002-0831-0973

Semenkov A.V.

Moscow Regional Research and Clinical Institute («MONIKI»);
I.M. Sechenov First Moscow State Medical University

ORCID: 0000-0002-7365-6081

Synchronous primary multiple cancer: distal cholangiocarcinoma of the intrapancreatic common bile duct and intraductal papillary mucinous tumor associated with ductal adenocarcinoma of the pancreatic tail

Authors:

Setdikova G.R., Stepanova E.A., Verbovsky A.N., Semenkov A.V.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2024;(8): 57‑63

DOI: 10.17116/hirurgia202408157

Read: 1524 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Setdikova GR, Stepanova EA, Verbovsky AN, Semenkov AV. Synchronous primary multiple cancer: distal cholangiocarcinoma of the intrapancreatic common bile duct and intraductal papillary mucinous tumor associated with ductal adenocarcinoma of the pancreatic tail. Pirogov Russian Journal of Surgery. 2024;(8):57‑63. (In Russ.)
https://doi.org/10.17116/hirurgia202408157

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

Cystic-solid transformation of the pancreas and kidneys due to von Hippel-Lindau disease. Pirogov Russian Journal of Surgery. 2025;(10):118-125

Abstract:

We present a combination of distal cholangiocarcinoma of the intrapancreatic common bile duct and intraductal papillary mucinous tumor associated with ductal adenocarcinoma of the pancreatic tail. This clinical case is unique. When analyzing the literature, we found no any case of similar primary multiple malignant tumor. Importantly, final diagnosis of simultaneous malignant pancreatobiliary neoplasia is possible only via intraoperative biopsy after adequate morphological dissection and research of resected organ complex including molecular genetic analysis due to identical histological and immunohistochemical picture of ductal neoplasia.

Keywords:

synchronous primary multiple cancer

cholangiocarcinoma

intrapancreatic common bile duct

intraductal papillary mucinous tumor

intraductal adenocarcinoma

pancreas

bile duct

Authors:

Setdikova G.R.

Vladimirsky Moscow Regional Research Clinical Institute

ORCID: 0000-0002-5262-4953

Stepanova E.A.

M.F. Vladimirsky Moscow Regional Clinical Research Institute

ORCID: 0000-0002-9037-0034

Verbovsky A.N.

Vladimirsky Moscow Regional Research Clinical Institute

ORCID: 0000-0002-0831-0973

Semenkov A.V.

Moscow Regional Research and Clinical Institute («MONIKI»);
I.M. Sechenov First Moscow State Medical University

ORCID: 0000-0002-7365-6081

Received:

14.04.2024

Accepted:

10.05.2024

Close metadata

References:

Rungsakulkij N, Boonsakan P. Synchronous gallbladder and pancreatic cancer associated with pancreaticobiliary maljunction. World Journal of Gastroenterology. 2014;20(39):14500-14504. https://doi.org/10.3748/wjg.v20.i39.14500
Taniai T, Haruki K, Shiba H, Onda S, Sakamoto T, Yanaga K. Simultaneous Resection for Synchronous Double Primary Cancers of the Pancreas and the Liver. Case Reports in Gastroenterology. 2018;12(2):504-512. https://doi.org/10.1159/000490658
Eriguchi N, Aoyagi S, Hara M, Okuda K, Tamae T, Fukuda S, Hashino K, Sato S, Fujiki K, Furukawa S, Jimi A. Synchronous or metachronous double cancers of the pancreas and other organs: report on 12 cases. Surgery Today. 2000;30(8):718-721. https://doi.org/10.1007/s005950070083
Sastry A, Wayne M, Steele J, Iskandar M, Yuan S, Cooperman AM. Three synchronous, sporadic and separate periampullary and pancreatic tumors: more than a coincidence? World Journal of Surgical Oncology. 2014;12:382. https://doi.org/10.1186/1477-7819-12-382
Nanashima A, Kondo H, Nakashima M, Abo T, Arai J, Ishii M, Hidaka S, Kunizaki M, To K, Takeshita H, Yamasaki N, Tsuchiya T, Nagayasu T. Clinicopathological characteristics of multiple primary cancers in hepatobiliary and pancreas malignancies. Anticancer Research. 2015;35(2):1073-1083.
Yamamura K, Hashimoto D, Kitano Y, Kuroda D, Eto T, Arima K, Kaida T, Miyata T, Nakagawa S, Imai K, Yamashita YI, Chikamoto A, Matsumura F, Baba H. Multiple Primary Cancers in Patients with Pancreatic Cancer. American Surgeon. 2018;84(12):e514-e516.
Shin SJ, Park H, Sung YN, Yoo C, Hwang DW, Park JH, Kim KP, Lee SS, Ryoo BY, Seo DW, Kim SC, Hong SM. Prognosis of Pancreatic Cancer Patients with Synchronous or Metachronous Malignancies from Other Organs Is Better than Those with Pancreatic Cancer Only. Cancer Research and Treatment. 2018;50(4):1175-1185. https://doi.org/10.4143/crt.2017.494
Likhvantsev VV, Zabelina TS, Grebenchikov OA, Shapkin MA. Perioperative management of patients with diabetes mellitus. Anesteziologiya i reanimatologiya. 2016;61(4):290-293. (In Russ.). https://doi.org/10.18821/0201-7563-2016-4-290-293
Dasanu CA, Shimanovsky A, Rotundo EK, Posteraro AF, Cooper DL, Atienza JA. Collision tumors: pancreatic adenocarcinoma and mantle cell lymphoma. JOP. 2013;14(4):458-462. https://doi.org/10.6092/1590-8577/1533
Pokataev IA, Gladkov OA, Zagainov VE, Kudashkin NE, Kuchin DM, Lyadov VK, Podluzhny DV, Tryakin AA, Fedyanin MYu, Chernykh MV. Practical recommendations for drug treatment of pancreatic cancer. Malignant tumors. 2022;12(3s2-1):530-544. (In Russ.). https://doi.org/10.18027/2224-5057-2021-11-3s2-27
Fendrich V, Waldmann J, Bartsch DK, Schlosser K, Rothmund M, Gerdes B. Multiple primary malignancies in patients with sporadic pancreatic endocrine tumors. Journal of Surgical Oncology. 2008;97(7):592-595. https://doi.org/10.1002/jso.21044
Paklina OV, Setdikova GR, Rotin DL. Key moments of morphological examination of pancreatic tumors considering modern morphological classification. Annals of HPB Surgery. 2019;24(3):12-21. (In Russ.). https://doi.org/10.16931/1995-5464.2019312-21
Kodaganur S, Hosamani IR. Synchronous malignancies of the gall bladder and common bile duct: a case report. World Journal of Surgical Oncology. 2016;14:106. https://doi.org/10.1186/s12957-016-0848-y
Luo J. KRAS mutation in pancreatic cancer. Seminars in Oncology. 2021;48(1):10-18. https://doi.org/10.1053/j.seminoncol.2021.02.003
Wang X, Allen S, Blake JF, Bowcut V, Briere DM, Calinisan A, Dahlke JR, Fell JB, Fischer JP, Gunn RJ, Hallin J, Laguer J, Lawson JD, Medwid J, Newhouse B, Nguyen P, O’Leary JM, Olson P, Pajk S, Rahbaek L, Rodriguez M, Smith CR, Tang TP, Thomas NC, Vanderpool D, Vigers GP, Christensen JG, Marx MA. Identification of MRTX1133, a Noncovalent, Potent, and Selective KRASG12D Inhibitor. Journal of Medicinal Chemistry. 2022;65(4):3123-3133. https://doi.org/10.1021/acs.jmedchem.1c01688
Shen H, Lundy J, Strickland AH, Harris M, Swan M, Desmond C, Jenkins BJ, Croagh D. KRAS G12D Mutation Subtype in Pancreatic Ductal Adenocarcinoma: Does It Influence Prognosis or Stage of Disease at Presentation? Cells. 2022;11(19):3175. https://doi.org/10.3390/cells11193175
Sedakov IE, Ishchenko RV, Antipov VN, Pivovarov NN, Bondar AV, Kolomiets KS. Short-term results of regional chemotherapy in locally advanced cancer of the head of the pancreas. Neoplasm. 2019;1(24):15-20. (In Russ.). https://doi.org/10.26435/neoplasm.v11i1.270
Setdikova GR Karpov AA, Paklina OV, Knyshinsky GV, Tavobilov MM, Shabunin AV. Morphological background of intraoperative radiation therapy appliance to prevent locoregional progression in patients with pancreatic ductal adenocarcinoma. Malignant Tumours. 2017;(1):52-60. (In Russ.). https://doi.org/10.18027/2224-5057-2017-1-52-60