Repeated liver resections for recurrent intrahepatic cholangiocarcinoma

Polyakov AN, Patyutko YuI, Chistyakova OV, et al. . Repeated liver resections for recurrent intrahepatic cholangiocarcinoma. Pirogov Russian Journal of Surgery. 2024;(9):30‑37. (In Russ., In Engl.)
https://doi.org/10.17116/hirurgia202409130

Подписка 2025 (Pirogov Russian Journal of Surgery)

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OBJECTIVE

To evaluate the safety and advisability of repeated liver resection (RLR) for recurrent intrahepatic cholangiocarcinoma (ICC).

MATERIAL AND METHODS

The results of RLR for ICC recurrence (n=10) were retrospectively analyzed between 1999 and 2023. The control group consisted of patients undergoing primary liver resection for ICC (n=195).

RESULTS

Surgery time (p=0.001) and blood loss (p=0.038) were lower in the RLR group. There were no blood transfusions (0 vs. 31.8%, p=0.034) and 90-day mortality (0 vs. 3.2%, p=1.0) in the same group. The risk of complications (30.0% vs.45.6%, p=0.517) and adverse events grade ≥ III (20.0% vs. 17.9%, p=1.0) was similar in both groups. Multifocal intrahepatic nodes were more common in the RLR group (60% vs. 37.9%, p=0.193), while there were no negative factors such as lymph nodes involvement (0 vs. 34.4%, p=0.032) and invasion of surrounding structures (0 vs. 38.5%, p=0.015). Dimensions of the largest node were smaller in repeated resection (2 vs. 8 cm, p<0.0001). Incidence of R0 resections (80.0% vs. 82.1%, p=1.0) was comparable. Long-term results were similar: five-year overall survival 17.2% and 34.7% (p=0.912), three-year disease-free survival 20.0% and 26.5% (p=0.421).

CONCLUSION

Similar results of repeated and primary liver resections confirm advisability of RLR for intrahepatic recurrence of ICC.

Keywords:

cholangiocarcinoma

intrahepatic bile duct cancer

intrahepatic recurrence

redo resection

Authors:

Polyakov A.N.

Blokhin National Cancer Research Center

SPIN RSCI: 9924-0256
Scopus AuthorID: 57190413973
ORCID: 0000-0001-5348-5011

Patyutko Yu.I.

Blokhin National Cancer Research Center

RSCI AuthorID: 137980
Scopus AuthorID: 55666204300
ORCID: 0000-0001-9254-1346

Chistyakova O.V.

Blokhin National Cancer Research Center

ORCID: 0000-0002-2958-2855

Kotelnikov A.G.

Blokhin National Cancer Research Center

ORCID: 0000-0002-2811-0549

Sergeeva O.N.

Blokhin National Cancer Research Center

SPIN RSCI: 5427-7357
ORCID: 0000-0003-1932-5983

Umirzokov A.Sh.

Blokhin National Cancer Research Center

ORCID: 0000-0001-9126-3153

Shishkina N.A.

Blokhin National Cancer Research Center

ORCID: 0000-0002-5037-9085

Podluzhny D.V.

Blokhin National Cancer Research Center

ORCID: 0000-0001-7375-3378

Received:

05.03.2024

Accepted:

28.03.2024

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