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Belov Yu.V.

Petrovsky National Research Center of Surgery;
Sechenov First Moscow State Medical University

Lysenko A.V.

Petrovsky Russian Scientific Center of Surgery

Akselrod B.A.

Petrovsky National Research Center of Surgery

Kulinchenko O.S.

Petrovsky National Research Center of Surgery

Lednev P.V.

Petrovsky Russian Scientific Center of Surgery

Salagaev G.I.

Petrovsky Russian Scientific Center of Surgery

Solovyova S.E.

Petrovsky National Research Center of Surgery

Ivanova A.G.

Petrovsky National Research Centre of Surgery

Clinical, biochemical and histological indicators of Del Nido cardioplegia efficacy in patients with severe myocardial hypertrophy

Authors:

Belov Yu.V., Lysenko A.V., Akselrod B.A., Kulinchenko O.S., Lednev P.V., Salagaev G.I., Solovyova S.E., Ivanova A.G.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2023;(12): 59‑66

DOI: 10.17116/hirurgia202312159

Views: 1209

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Table of contents

CLINICAL, BIOCHEMICAL AND HISTOLOGICAL INDICATORS OF DEL NIDO CARDIOPLEGIA EFFICACY IN PATIENTS WITH SEVERE MYOCARDIAL HYPERTROPHY
CLINICAL, BIOCHEMICAL AND HISTOLOGICAL INDICATORS OF DEL NIDO CARDIOPLEGIA EFFICACY IN PATIENTS WITH SEVERE MYOCARDIAL HYPERTROPHY

To cite this article:

Belov YuV, Lysenko AV, Akselrod BA, et al. . Clinical, biochemical and histological indicators of Del Nido cardioplegia efficacy in patients with severe myocardial hypertrophy. Pirogov Russian Journal of Surgery. 2023;(12):59‑66. (In Russ.)
https://doi.org/10.17116/hirurgia202312159

Подписка 2025-2 (Pirogov Russian Journal of Surgery)
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OBJECTIVE

To evaluate the effectiveness of two cardioplegia techniques in patients with severe myocardial hypertrophy undergoing septal myectomy or aortic valve replacement.

MATERIAL AND METHODS

A comparative pilot prospective single-center randomized study included 46 patients between 2022 and 2023. Patients were randomized into 2 groups: Del Nido (n=23) and Custodiol (n=23). We analyzed perioperative echocardiography data, troponin I at several time points, perioperative complications and histological data.

RESULTS

Both groups were comparable in time of myocardial ischemia, cardiopulmonary bypass, duration of anesthesia and surgery (p>0.05). The maximum ischemia time in the Del Nido group was 84 min. The same group showed significantly higher percentage of spontaneous rhythm recovery (65.2% vs. 30%, p=0.008). None patient required mechanical support, high-dose inotropes or vasopressors. Troponin I in 2 hours after cardiopulmonary bypass (p=0.415), 12 (p=0.528) and 24 hours after admission to the intensive care unit (p=0.281) were similar in both groups. No significant difference was found in ventilation time, ICU- and hospital-stay.

CONCLUSION

Del Nido cardioplegia has some advantages compared to Custodiol and does not lead to perioperative complications in case of aortic cross-clamping time <90 min in patients with myocardial hypertrophy.

Keywords:

cardioplegia
myocardial hypertrophy
myocardial protection
del Nido

Authors:

Belov Yu.V.

Petrovsky National Research Center of Surgery;
Sechenov First Moscow State Medical University

Lysenko A.V.

Petrovsky Russian Scientific Center of Surgery

Akselrod B.A.

Petrovsky National Research Center of Surgery

Kulinchenko O.S.

Petrovsky National Research Center of Surgery

Lednev P.V.

Petrovsky Russian Scientific Center of Surgery

Salagaev G.I.

Petrovsky Russian Scientific Center of Surgery

Solovyova S.E.

Petrovsky National Research Center of Surgery

Ivanova A.G.

Petrovsky National Research Centre of Surgery

Received:

10.09.2023

Accepted:

29.09.2023

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