The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Maĭborodin I.V.

NII klinicheskoĭ i éksperimental'noĭ limfologii SO RAMN, Novosibirsk

Figurenko N.F.

The Center of New Medical Technologies Institute of Chemical Biology and Fundamental Medicine, The Russian Academy of Sciences, Siberian Branch Novosibirsk, Russia

Maiborodina V.I.

Laboratory of ultrastructural bases of pathology, Institute of Molecular Pathology and Pathomorphology, Federal State Budget Scientific Institution «Federal Research Center of Fundamental and Translational Medicine», Novosibirsk, Russia

Onoprienko N.V.

Kafedra akusherstva i ginekologii Novosibirskogo gosudarstvennogo meditsinskogo universiteta Roszdrava

Liver regeneration after resection in clinical and experimental conditions

Authors:

Maĭborodin I.V., Figurenko N.F., Maiborodina V.I., Onoprienko N.V.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2020;(4): 47‑52

DOI: 10.17116/hirurgia202004147

Read: 25567 times

Download PDF (RU)
Contact the author
Table of contents

LIVER REGENERATION AFTER RESECTION IN CLINICAL AND EXPERIMENTAL CONDITIONS
LIVER REGENERATION AFTER RESECTION IN CLINICAL AND EXPERIMENTAL CONDITIONS

To cite this article:

Maĭborodin IV, Figurenko NF, Maiborodina VI, Onoprienko NV. Liver regeneration after resection in clinical and experimental conditions. Pirogov Russian Journal of Surgery. 2020;(4):47‑52. (In Russ.)
https://doi.org/10.17116/hirurgia202004147

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Textbook outcome for liver rese­ction. Survey of respondents in national centers. Piro­gov Russian Journal of Surgery. 2025;(4):5-11
Stru­ctural and functional tissue response to implants in patients with recu­rrent abdo­minal wall hernias in long-term period. Piro­gov Russian Journal of Surgery. 2025;(4):39-45
Effe­ctiveness of local treatment of venous trophic ulcers in gero­ntological patients. Piro­gov Russian Journal of Surgery. 2025;(8):45-54
Clinical, labo­ratory and morphological comparisons in cellular alte­ration under conditions of hypo­xia. Russian Journal of Archive of Pathology. 2024;(5):42-52
Arti­ficial inte­lligence-based software for digi­tal asse­ssment of repa­rative bone tissue rege­neration. Rege­nerative Biotechnologies, Preventive, Digi­tal and Predictive Medi­cine. 2025;(1):19-24
Analysis of differential gene expression in myocardial tissue from patients with hype­rtrophic cardiomyopathy. Mole­cular Gene­tics, Microbiology and Viro­logy. 2025;(1):17-23
Role of post-procedure care in skin reha­bilitation after hardware procedures with skin cove­rage damage. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(2):240-244
Liver invo­lvement in Gaucher disease in children: A lite­rature review and clinical obse­rvations. Russian Journal of Evidence-Based Gastroenterology. 2025;(2):78-93
New possibilities for professional skin care after hardware procedures in aesthetic cosmetology. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(3):376-380
The type 1 diabetes mellitus treatment. Russian Journal of Preventive Medi­cine. 2025;(8):131-137
Abstract:

The researches devoted to postoperative liver regeneration and influence in this process were analyzed. Liver injury is followed by hypertrophy of residual liver parenchyma. The use of various cytokines is perspective for activation, acceleration and inhibition of liver recovery. Cellular technologies in the treatment of liver diseases can affect its repair. Moreover, these methods could make unnecessary resection and transplantation of liver in certain cases. It is generally accepted that the main effect of multipotent stromal cells (MSC) in liver failure is associated with their differentiation to the cellular elements of this organ. At the same time, recent reports revealed that MSC injection to the liver is followed by their quick death, dissemination to other organs and tissues or even elimination from the organism. Regeneration of non-parenchymal structures (vascular network and bile ducts) should be considered in addition to functional recovery of liver parenchyma after resection. Clarification of indications and contraindications for MSC therapy, as well as prevention of possible complications associated with cellular technologies are required.

Keywords:

liver
resection
regeneration
hypertrophy
hyperplasia
sclerosis
multipotent stromal cells

Authors:

Maĭborodin I.V.

NII klinicheskoĭ i éksperimental'noĭ limfologii SO RAMN, Novosibirsk

Figurenko N.F.

The Center of New Medical Technologies Institute of Chemical Biology and Fundamental Medicine, The Russian Academy of Sciences, Siberian Branch Novosibirsk, Russia

Maiborodina V.I.

Laboratory of ultrastructural bases of pathology, Institute of Molecular Pathology and Pathomorphology, Federal State Budget Scientific Institution «Federal Research Center of Fundamental and Translational Medicine», Novosibirsk, Russia

Onoprienko N.V.

Kafedra akusherstva i ginekologii Novosibirskogo gosudarstvennogo meditsinskogo universiteta Roszdrava

Close metadata

References:

  1. Sipahi M, Şahin S, Arslan E, Börekci H, Metin B, Cantürk NZ. Effect of the human amniotic membrane on liver regeneration in rats. 2015;2015:706186.
  2. Rozga J. Hepatocyte proliferation in health and in liver failure. 2002;8(2):RA32-8.
  3. Kwon KH, Kim YW, Kim SI, Kim KS, Lee WJ, Choi JS. Postoperative liver regeneration and complication in live liver donor after partial hepatectomy for living donor liver transplantation. 2003;44(6):1069-1077.
  4. Ibis C, Asenov Y, Akin M, Azamat IF, Sivrikoz N, Gurtekin B. Factors affecting liver regeneration in living donors after hepatectomy. 2017;23:5986-5993.
  5. Aoki T, Imamura H, Matsuyama Y, Kishi Y, Kobayashi T, Sugawara Y, Makuuchi M, Kokudo N. Convergence process of volumetric liver regeneration after living-donor hepatectomy. . 2011;15(9):1594-1601.
  6. Weiss TS, Dayoub R. Thy-1 (CD90)-positive hepatic progenitor cells, hepatoctyes, and non-parenchymal liver cells isolated from human livers. 2017;1506:75-89.
  7. Andersen KJ, Knudsen AR, Kannerup AS, Sasanuma H, Nyengaard JR, Hamilton-Dutoit S, Erlandsen EJ, Jørgensen B, Mortensen FV. The natural history of liver regeneration in rats: description of an animal model for liver regeneration studies. . 2013;11(9):903-908. 
  8. Schleimer K, Stippel DL, Kasper HU, Allwissner R, Yavuzyasar S, Hölscher AH, Beckurts KT. Competition between native liver and graft in auxiliary liver transplantation in a rat model. 2008;40(4):967-970. 
  9. Masson S, Daveau M, Hiron M, Lyoumi S, Lebreton JP, Ténière P, Scotté M. Differential regenerative response and expression of growth factors following hepatectomy of variable extent in rats. . 1999;19(4):312-317.
  10. Sakaguchi K, Takeuchi E, Suzuki M, Oda K, Nagino M, Nimura Y, Yoshida S. DNA polymerases and Ki-67 nuclear antigen are induced in correlation with the resected mass of rat liver up to 90%. 2000;385(2):135-142.
  11. Makino H, Togo S, Kubota T, Morioka D, Morita T, Kobayashi T, Tanaka K, Shimizu T, Matsuo K, Nagashima Y, Shimada H. A good model of hepatic failure after excessive hepatectomy in mice. 2005;127(2):171-176. 
  12. Mayborodin IV, Figurenko NF, Morozov VV, Maslov RV, Mikheeva TV, Mayborodina VI, Filipovich ON, Kadyrova AI, Shevela AI. Damage of the vessels in the time of liver resection may result in atrophy and fibrose of the whole organ’s lobe in experiment. 2018;7(4):18-27. (In Russ.)
  13. Swiderska-Syn M, Syn WK, Xie G, Krüger L, Machado MV, Karaca G, Michelotti GA, Choi SS, Premont RT, Diehl AM. Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy. . 2014;63(8):1333-1344.
  14. Umeda Y, Iwagaki H, Ozaki M, Ogino T, Iwamoto T, Yoshida R, Shinoura S, Matsuda H, Sadamori H, Tanaka N, Yagi T. Refractory response to growth factors impairs liver regeneration after hepatectomy in patients with viral hepatitis. . 2009;56(93):971-977.
  15. Masson S, Scotté M, Garnier S, François A, Hiron M, Ténière P, Fallu J, Salier JP, Daveau M. Differential expression of apoptosis-associated genes post-hepatectomy in cirrhotic vs. normal rats. . 2000;5(2):173-179.
  16. Kaido T, Yoshikawa A, Seto S, Yamaoka S, Sato M, Ishii T, Imamura M. Portal branch ligation with a continuous hepatocyte growth factor supply makes extensive hepatectomy possible in cirrhotic rats. . 1998;28(3):756-760. 
  17. Ueno M, Uchiyama K, Nakamori M, Ueda K, Iwahashi M, Ozawa S, Yamaue H. Adenoviral vector expressing hepatocyte growth factor promotes liver regeneration by preoperative injection: the advantages of performing selective injection to the remnant lobe. . 2007;141(4):511-519. 
  18. Zhang M, Gong Y, Corbin I, Mellon A, Choy P, Uhanova J, Minuk GY. Light ethanol consumption enhances liver regeneration after partial hepatectomy in rats. . 2000;119(5):1333-1339.
  19. Stutchfield BM, Antoine DJ, Mackinnon AC, Gow DJ, Bain CC, Hawley CA, Hughes MJ, Francis B, Wojtacha D, Man TY, Dear JW, Devey LR, Mowat AM, Pollard JW, Park BK, Jenkins SJ, Simpson KJ, Hume DA, Wigmore SJ, Forbes SJ. CSF1 restores innate immunity after liver injury in mice and serum levels indicate outcomes of patients with acute liver failure. . 2015;149(7):1896-1909.e14. 
  20. Haga H, Yan IK, Borrelli DA, Matsuda A, Parasramka M, Shukla N, et al. Extracellular vesicles from bone marrow-derived mesenchymal stem cells protect against murine hepatic ischemia/reperfusion injury. . 2017;23(6):791-803. 
  21. Booth C, Soker T, Baptista P, Ross CL, Soker S, Farooq U, Stratta RJ, Orlando G. Liver bioengineering: current status and future perspectives. 2012;18(47):6926-6934.
  22. Adas G, Koc B, Adas M, Duruksu G, Subasi C, Kemik O, Kemik A, Sakiz D, Kalayci M, Purisa S, Unal S, Karaoz E. Effects of mesenchymal stem cells and VEGF on liver regeneration following major resection. 2016;401(5):725-740. 
  23. Inagaki NF, Inagaki FF, Kokudo N, Miyajima A. Use of mouse liver mesothelial cells to prevent postoperative adhesion and promote liver regeneration after hepatectomy. 2015;62(5):1141-1147.
  24. Haga J, Enosawa S, Kobayashi E. Cell therapy for liver disease using bioimaging rats. . 2016;9(1-2):3-7. 
  25. Xu LJ, Wang SF, Wang DQ, Ma LJ, Chen Z, Chen QQ, Wang J, Yan L. Adipose-derived stromal cells resemble bone marrow stromal cells in hepatocyte differentiation potential in vitro and in vivo. 2017;23(38):6973-6982.
  26. Wang M, Zhang X, Xiong XI, Yang Z, Li P, Wang J, Sun YU, Yang Z, Hoffman RM. Bone marrow mesenchymal stem cells reverse liver damage in a carbon tetrachloride-induced mouse model of chronic liver injury. 2016;30(3):187-193.
  27. Cai Y, Zou Z, Liu L, Chen S, Chen Y, Lin Z, Shi K, Xu L, Chen Y. Bone marrow-derived mesenchymal stem cells inhibits hepatocyte apoptosis after acute liver injury. . 2015;8(1):107-116.
  28. Chen S, Xu L, Lin N, Pan W, Hu K, Xu R. Activation of Notch1 signaling by marrow-derived mesenchymal stem cells through cell-cell contact inhibits proliferation of hepatic stellate cells. 2011;89(25-26):975-981. 
  29. Liu JJ, Hu XJ, Li ZR, Yan RH, Li D, Wang J, Shan H. In vivo bioluminescence imaging of transplanted mesenchymal stromal cells and their rejection mediated by intrahepatic NK cells. 2017;19(1):31-40. 
  30. Witte de SFH, Merino AM, Franquesa M, Strini T, van Zoggel JAA, Korevaar SS, et al. Cytokine treatment optimises the immunotherapeutic effects of umbilical cord-derived MSC for treatment of inflammatory liver disease. 2017;8(1):140. 
  31. Mayborodin IV, Figurenko NF, Elovsky AA, Mikheeva TV, Maslov RV, Mayborodina VI, Shevela AI. Possibility of inflammatory injures development in intact liver after the multipotent stromal cell injection in experiment. 2019;27(1):5-15. (In Russ.)
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.