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Maĭborodin I.V.

NII klinicheskoĭ i éksperimental'noĭ limfologii SO RAMN, Novosibirsk

Figurenko N.F.

The Center of New Medical Technologies Institute of Chemical Biology and Fundamental Medicine, The Russian Academy of Sciences, Siberian Branch Novosibirsk, Russia

Maiborodina V.I.

Laboratory of ultrastructural bases of pathology, Institute of Molecular Pathology and Pathomorphology, Federal State Budget Scientific Institution «Federal Research Center of Fundamental and Translational Medicine», Novosibirsk, Russia

Onoprienko N.V.

Kafedra akusherstva i ginekologii Novosibirskogo gosudarstvennogo meditsinskogo universiteta Roszdrava

Liver regeneration after resection in clinical and experimental conditions

Authors:

Maĭborodin I.V., Figurenko N.F., Maiborodina V.I., Onoprienko N.V.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2020;(4): 47‑52

DOI: 10.17116/hirurgia202004147

Read: 24776 times

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Table of contents

LIVER REGENERATION AFTER RESECTION IN CLINICAL AND EXPERIMENTAL CONDITIONS
LIVER REGENERATION AFTER RESECTION IN CLINICAL AND EXPERIMENTAL CONDITIONS

To cite this article:

Maĭborodin IV, Figurenko NF, Maiborodina VI, Onoprienko NV. Liver regeneration after resection in clinical and experimental conditions. Pirogov Russian Journal of Surgery. 2020;(4):47‑52. (In Russ.)
https://doi.org/10.17116/hirurgia202004147

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The researches devoted to postoperative liver regeneration and influence in this process were analyzed. Liver injury is followed by hypertrophy of residual liver parenchyma. The use of various cytokines is perspective for activation, acceleration and inhibition of liver recovery. Cellular technologies in the treatment of liver diseases can affect its repair. Moreover, these methods could make unnecessary resection and transplantation of liver in certain cases. It is generally accepted that the main effect of multipotent stromal cells (MSC) in liver failure is associated with their differentiation to the cellular elements of this organ. At the same time, recent reports revealed that MSC injection to the liver is followed by their quick death, dissemination to other organs and tissues or even elimination from the organism. Regeneration of non-parenchymal structures (vascular network and bile ducts) should be considered in addition to functional recovery of liver parenchyma after resection. Clarification of indications and contraindications for MSC therapy, as well as prevention of possible complications associated with cellular technologies are required.

Keywords:

liver
resection
regeneration
hypertrophy
hyperplasia
sclerosis
multipotent stromal cells

Authors:

Maĭborodin I.V.

NII klinicheskoĭ i éksperimental'noĭ limfologii SO RAMN, Novosibirsk

Figurenko N.F.

The Center of New Medical Technologies Institute of Chemical Biology and Fundamental Medicine, The Russian Academy of Sciences, Siberian Branch Novosibirsk, Russia

Maiborodina V.I.

Laboratory of ultrastructural bases of pathology, Institute of Molecular Pathology and Pathomorphology, Federal State Budget Scientific Institution «Federal Research Center of Fundamental and Translational Medicine», Novosibirsk, Russia

Onoprienko N.V.

Kafedra akusherstva i ginekologii Novosibirskogo gosudarstvennogo meditsinskogo universiteta Roszdrava

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