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Shelygin Yu.A.

Ryzhikh National Medical Research Centre for Coloproctology;
Russian Medical Academy of Continuous Professional Education

Sushkov O.I.

Ryzhikh National Medical Research Centre for Coloproctology

Sukhina M.A.

Ryzhikh National Medical Research Centre for Coloproctology

Saifutdinova K.R.

Russian Medical Academy of Continuous Professional Education

Muratov I.I.

Central Clinical Hospital of the Presidential Administration of the Russian Federation

Shakhmatov D.G.

Ryzhikh National Medical Research Centre of Coloproctology;
Russian Medical Academy of Postgraduate Education

Achkasov S.I.

State Research Centre of Coloproctology

Effectiveness of intraperitoneal chemotherapy for t4 colon cancer

Authors:

Shelygin Yu.A., Sushkov O.I., Sukhina M.A., Saifutdinova K.R., Muratov I.I., Shakhmatov D.G., Achkasov S.I.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2020;(10): 36‑43

DOI: 10.17116/hirurgia202010136

Read: 1908 times

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Table of contents

EFFECTIVENESS OF INTRAPERITONEAL CHEMOTHERAPY FOR T4 COLON CANCER
EFFECTIVENESS OF INTRAPERITONEAL CHEMOTHERAPY FOR T4 COLON CANCER

To cite this article:

Shelygin YuA, Sushkov OI, Sukhina MA, Saifutdinova KR, Muratov II, Shakhmatov DG, Achkasov SI. Effectiveness of intraperitoneal chemotherapy for t4 colon cancer. Pirogov Russian Journal of Surgery. 2020;(10):36‑43. (In Russ.)
https://doi.org/10.17116/hirurgia202010136

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To determine the effect of intraperitoneal chemotherapy (IPC) with mitomycin C on expression of intraperitoneal cancer cells markers in patients with T4 colon cancer.

MATERIAL AND METHODS

For the period from January 2019 to April 2020, 65 patients with T4 colon cancer were included in prospective comparative study. There were 46 patients in the main group and 19 patients in the control group. In the main group, surgical procedure was followed by IPC with mitomycin C. No IPC was performed in the control group. An effectiveness of IPC was evaluated using CD133, CD24, CD26, CD44, CD184 markers expression in peritoneal lavages.

RESULTS

Significant between-group differences were observed for CD133 (p=0.0168), CD24 (p=0.0455) and CD44 (p=0.0012). There was a tendency to decrease in the level of CD184 expression in both groups in the second lavage (p=0.0605).

CONCLUSION

IPC in patients with T4 colon cancer can reduce the expression and proliferative potential of free cancer cells.

Keywords:

intraperitoneal chemotherapy
cancer cell markers
colon cancer
fluorescence intensity

Authors:

Shelygin Yu.A.

Ryzhikh National Medical Research Centre for Coloproctology;
Russian Medical Academy of Continuous Professional Education

Sushkov O.I.

Ryzhikh National Medical Research Centre for Coloproctology

Sukhina M.A.

Ryzhikh National Medical Research Centre for Coloproctology

Saifutdinova K.R.

Russian Medical Academy of Continuous Professional Education

Muratov I.I.

Central Clinical Hospital of the Presidential Administration of the Russian Federation

Shakhmatov D.G.

Ryzhikh National Medical Research Centre of Coloproctology;
Russian Medical Academy of Postgraduate Education

Achkasov S.I.

State Research Centre of Coloproctology

Received:

08.06.2020

Accepted:

29.06.2020

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