This article deal with method of multimodal, opioid-free anesthesia for colorectal surgery in the perioperative period. The aim of this study is to improve the quality of treatment for patients with colorectal cancer using non-opioid anesthesia and analgesia in the perioperative period. Material and methods. The study included 47 patients who underwent laparoscopic colon surgery. This anesthesia method consists of epidural anesthesia with sevoflurane during surgery end epidural analgesia after surgery. We describe the method of non-opioid anesthesia technics during colorectal surgery. The pain syndrome was evaluated at various time intervals. Harvard standard for monitoring during anesthesia is presented. Results. Opioid-free anesthesia is safety method for colorectal surgery. It was also possible to reduce the incidence of postoperative nausea and vomiting, pain, intestinal paresis, the duration of hospitalization, and rise quality of medical care for patient with colorectal cancer.