Aim — to assess clinico-biochemical and functional parameters in patients with Q-AMI at different stages of the disease on background of dietary correction with selenium and standard therapy. Material and methods. The trial involved 90 STEMI patients (mean age 58.3±1.4 years). Patients were divided into 2 comparable groups: control group (standard therapy) and main group (selenium-enriched dietary product in addition to standard therapy). Results. In the main group anthropometric values was significantly improved: body weight decreased by 2.9%, waist circumference by 3.7% and hips circumference by 2.4%, body mass index (BMI) decreased by 3.2% (p<0.005) in contrast to the control group. There was significant correlation between serum selenium level and myocardial necrosis marker of creatine phosphokinase (CK) (r=–0.3; p=0.016) and CK-MB (r=–0.4; p=0.0001); some blood tests: atherogenicity coefficient (r=–0.2; p=0.071), potassium (r=0.4; p=0.00001), international normalized ratio (INR) (r=–0.3; p=0.001), prothrombin index (PI) (r=0.2; p=0.017), leukocytes (r=–0.2; p=0.042), neutrophils (r=–0.3; p=0.016) and thrombocytes (r=–0.4; p=0.01). Echocardiography revealed inverse correlation between serum selenium level and LV end-diastolic and end-systolic dimensions (–0.3; p=0.028 and –0.3; p=0.024, respectively), LA dimensions (–0.3; p=0.025), mitral regurgitation (MR) severity (–0.4; p=0.001), the number of akinesia segments (–0.3; p=0.018) and direct relationship with LV ejection fraction (0.3; p=0.004). This contributed to significant improvement of functional myocardial state in the main group that was confirmed by ECG data: signs of ischemia, damage and myocardial necrosis were significantly decreased. There was significant positive effect of selenium on arterial compliance and vascular dilatation in the main group. According to various questionnaires selenium contributed to significant improvement of quality of life and the course of the disease. Conclusion. Selenium promotes positive dynamics of clinico-functional and biochemical values in STEMI patients in addition to standard therapy.