Aim. To analyze the features of perfusion, intensive care and the results of pulmonary endarterectomy. Material and methods. The study included 17 patients with CTEPH. There were 58.8% of women, 17.6% of cases of diabetes type 2. Congenital thrombophilia was observed in 70.5% of cases, antiphospholipid syndrome (APS) — in 29.4%, chronic kidney disease stage II—III — in 23.5%. All patients underwent pulmonary endarterectomy. In 2 cases pulmonary endarterectomy was combined with other interventions including CABG in one case and removal of interatrial septal stent followed by IAS repair in other case. Lethal outcomes after surgery were observed in three cases (17.6%) including in-hospital mortality in 2 of them (11.7%). The causes of death were massive pulmonary hemorrhage, multiple organ failure, hemothorax on the background of recurrent pulmonary hypertension, progressive pulmonary-cardiac insufficiency. Acute renal failure (ARF) developed in 2 cases. In one patient we obtained reversible ARF stage II according to RIFLE 2004 [1] with maximum increase of plasma creatinine more than two times in 24 hours after surgery and normalization by the 5th day. In this case we noted urine NGAL augmentation up to 439 ng/mL in 4 hours after surgery followed by decrease to 37.4 and 7.1 ng/ml by the 2nd and the 3rd day respectively. In the second case ARF was accompanied by multiple organ failure that resulted death.