Results of 75 biological prostheses explantations (17 stentless and 6 stented aortic, 40 mitral and 12 tricuspid) were analyzed. The main problems during excision of aortic bioprosthesis were gross calcification of biomaterial (71%) and extensive damage of paravalvular structures (17-24%). In atrioventricular positions technical difficulties were caused by gross changes of subvalvular structures and their fusion with elements of prosthetic structure (5-33%). It is drawn a conclusion that recurrent cardiac intervention necessary for bioprosthesis explantation should be considered as an opportunity to identify specific peculiarities (prosthetic calcification, necessity for prosthetic annuloplasty or prosthetic aortic root replacementt, probability of a rough fusion of subvalvular structures with prosthesis, need for pacemaker reimplantation), and general features distinctive for complications of recurrent cardiac operations.