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Garbuzova E.V.

Research Institute of Internal and Preventive Medicine — Branch of the Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences

Kuznetsov A.A.

Research Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics

Nesterets A.M.

Research Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics

Afanaseva A.D.

Research Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences

Shramko V.S.

Research Institute of Internal and Preventive Medicine — Branch of the Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences

Imaeva A.E.

National Medical Research Center for Therapy and Preventive Medicine

Muromtseva G.A.

National Medical Research Centre for Therapy and Preventive Medicine

Balanova Yu.A.

National Medical Research Center for Therapy and Preventive Medicine

Simonova G.I.

Research Institute of Internal and Preventive Medicine — Branch of Federal Research Center Institute of Cytology and Genetics Siberian Division of the Russian Academy of Sciences

Fragmented QRS is associated with hyperglycemia and low HDL levels in Novosibirsk residents (part of the ESSE-RF-3)

Authors:

Garbuzova E.V., Kuznetsov A.A., Nesterets A.M., Afanaseva A.D., Shramko V.S., Imaeva A.E., Muromtseva G.A., Balanova Yu.A., Simonova G.I.

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Journal: Russian Cardiology Bulletin. 2025;20(2): 46‑53

DOI: 10.17116/Cardiobulletin20252002146

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Table of contents

FRAGMENTED QRS IS ASSOCIATED WITH HYPERGLYCEMIA AND LOW HDL LEVELS IN NOVOSIBIRSK RESIDENTS (PART OF THE ESSE-RF-3)
FRAGMENTED QRS IS ASSOCIATED WITH HYPERGLYCEMIA AND LOW HDL LEVELS IN NOVOSIBIRSK RESIDENTS (PART OF THE ESSE-RF-3)

To cite this article:

Garbuzova EV, Kuznetsov AA, Nesterets AM, et al. . Fragmented QRS is associated with hyperglycemia and low HDL levels in Novosibirsk residents (part of the ESSE-RF-3). Russian Cardiology Bulletin. 2025;20(2):46‑53. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20252002146

 
ЭндоКард
Подписка 2026 Кардиологический вестник (Russian Cardiology Bulletin)
 
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Abstract:

OBJECTIVE

To study the associations of fragmented QRS (fQRS) with cardiometabolic risk factors in a sample of Novosibirsk residents.

MATERIAL AND METHODS

There were 982 residents of Novosibirsk (477 (48.6%) men) aged 35-74 years. Survey program included demographic and social data, anthropometry, blood pressure and electrocardiography. Cardiometabolic risk factors were determined according to appropriate criteria (2013). The fQRS of the lower left ventricular wall was used.

RESULTS

There was fQRS in 119 people (12.1%). It was more common in men (83/477 (17.4%) vs. 36/505 (7.1%), p<0.001), in patients with high blood pressure (62/425 (14.6%) vs. 57/557 (10.2%), p=0.038), high triglycerides (51/307 (16.6%) vs. 68/675 (10.1%), p=0.004) and glucose (53/295 (18.0%) vs. 66/687 (9.6%), p<0.001), low HDL cholesterol (28/143 (19.6%) vs. 91/839 (10.8%), p=0.003). The risk of fQRS was higher in patients with hypertension, hypertriglyceridemia, reduced serum HDL cholesterol and hyperglycemia. Fragmented QRS was associated with male sex, HDL ≥6.1 mmol/l, HDL cholesterol <1.0 mmol/l in men and <1.2 mmol/l in women regardless of other risk factors.

CONCLUSION

Fragmented QRS is more common in men and associated with hyperglycemia and low HDL cholesterol regardless of other risk factors. Our results emphasize the role of integrated assessment of significant indicators of myocardial fibrosis.

Keywords:

fragmentation of QRS
male gender
low HDL cholesterol
hyperglycemia

Authors:

Garbuzova E.V.

Research Institute of Internal and Preventive Medicine — Branch of the Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences

Kuznetsov A.A.

Research Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics

Nesterets A.M.

Research Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics

Afanaseva A.D.

Research Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences

Shramko V.S.

Research Institute of Internal and Preventive Medicine — Branch of the Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences

Imaeva A.E.

National Medical Research Center for Therapy and Preventive Medicine

Muromtseva G.A.

National Medical Research Centre for Therapy and Preventive Medicine

Balanova Yu.A.

National Medical Research Center for Therapy and Preventive Medicine

Simonova G.I.

Research Institute of Internal and Preventive Medicine — Branch of Federal Research Center Institute of Cytology and Genetics Siberian Division of the Russian Academy of Sciences

Received:

06.09.2024

Accepted:

30.09.2024

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