Hibernating myocardium volume in patients with chronic ischemic heart failure under modulation of myocardial contractility

Amanatova V.A.; Uskach T.M.; Safiullina A.A.; Ansheles A.A.; Tereshchenko S.N.; Sergienko V.B.

doi:https://doi.org/10.17116/Cardiobulletin20211603145

Amanatova V.A.

National Medical Research Center of Cardiology

Uskach T.M.

ORCID: 0000-0003-4318-0315

Safiullina A.A.

National Medical Research Center of Cardiology

Ansheles A.A.

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0002-2675-3276

Tereshchenko S.N.

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0001-9234-6129

Sergienko V.B.

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0002-0487-6902

Hibernating myocardium volume in patients with chronic ischemic heart failure under modulation of myocardial contractility

Authors:

Amanatova V.A., Uskach T.M., Safiullina A.A., Ansheles A.A., Tereshchenko S.N., Sergienko V.B.

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Journal: Russian Cardiology Bulletin. 2021;16(3): 45‑52

DOI: 10.17116/Cardiobulletin20211603145

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To cite this article:

Amanatova VA, Uskach TM, Safiullina AA, Ansheles AA, Tereshchenko SN, Sergienko VB. Hibernating myocardium volume in patients with chronic ischemic heart failure under modulation of myocardial contractility. Russian Cardiology Bulletin. 2021;16(3):45‑52. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20211603145

Подписка 2026 Кардиологический вестник (Russian Cardiology Bulletin)

Использование инфографики авторами научных работ

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Abstract:

OBJECTIVE

To analyze myocardial contractility and perfusion parameters according to single-photon myocardial perfusion scintigraphy (SPECT) under cardiac contractility modulation (CCM) and optimal drug therapy in patients with chronic ischemic heart failure (CHF).

MATERIAL AND METHODS

The study included 31 patients with CHF NYHA class II—III and coronary artery disease (CAD). All patients underwent perfusion SPECT of the myocardium with Technetium [99mTc] sestamibi before implantation of CCM-device and 6 months later. Perfusion defects were assessed using standard 17-segment mapping with Summed Rest Score (SRS), Extent and Total perfusion deficit (TPD) parameters. We analyzed myocardial contractility considering left ventricular ejection fraction (LVEF), end diastolic (EDV) and systolic volumes (ESV). Hibernating myocardium volume was assessed by comparison of resting polar maps of perfusion and contractility.

RESULTS

According to SPECT before implantation of CCM-device, median LVEF was 21% [17.5; 26.0]. After 6 months, this value significantly increased up to 25% [18.0; 25.0] (p=0.01). There was a tendency towards reduction of LV EDV from 255 [221; 290] to 221 [209; 262] ml (p=0.09) and LV ESV from 192 [171; 226] to 166 [155; 220] ml (p=0.08). No significant changes in perfusion defect volumes were revealed. CCM resulted significant decrease in hibernating myocardium volume after 6 months from 33 [12; 60] to 24% [12; 42] (p=0.04).

CONCLUSION

MCC therapy is able to improve myocardial contractility and reduce the volume of hibernating myocardium in patients with ischemic CHF.

Keywords:

perfusion single-photon-emission computed tomography

chronic heart failure with reduced ejection fraction

modulation of cardiac contractility

Authors:

Amanatova V.A.

National Medical Research Center of Cardiology

Uskach T.M.

ORCID: 0000-0003-4318-0315

Safiullina A.A.

National Medical Research Center of Cardiology

Ansheles A.A.

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0002-2675-3276

Tereshchenko S.N.

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0001-9234-6129

Sergienko V.B.

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0002-0487-6902

Received:

29.07.2021

Accepted:

18.08.2021

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