The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Grishenkova A.S.

Pirogov Russian National Research Medical University

Gavrilov S.G.

Pirogov Russian National Research Medical University

Current Data on Pathogenesis, Diagnosis and Correction of Pelvic Venous Pain

Authors:

Grishenkova A.S., Gavrilov S.G.

More about the authors

Journal: Journal of Venous Disorders. 2022;16(2): 145‑155

Read: 1668 times


To cite this article:

Grishenkova AS, Gavrilov SG. Current Data on Pathogenesis, Diagnosis and Correction of Pelvic Venous Pain. Journal of Venous Disorders. 2022;16(2):145‑155. (In Russ.)
https://doi.org/10.17116/flebo202216021145

Recommended articles:

References:

  1. Borghi C, Dell’Atti L. Pelvic congestion syndrome: the current state of the literature. Arch Gynecol Obstet 2016;293(2):291-301.  https://doi.org/10.1007/s00404-015-3895-7
  2. Zondervan KT, Yudkin PL, Vessey MP, Jenkinson CP, Dawes MG, Barlow DH, Kennedy SH. The community prevalence of chronic pelvic pain in women and associated illness behaviour. The British Journal of General Practice: The Journal of the Royal College of General Practitioners. 2001;51(468):541-547. 
  3. Mathias SD, Kuppermann M, Liberman RF, Lipschutz RC, Steege JF. Chronic pelvic pain: prevalence, health-related quality of life, and economic correlates. Obstetrics and gynecology. 1996;87(3):321-327.  https://doi.org/10.1016/0029-7844(95)00458-0
  4. Zondervan K, Barlow DH. Epidemiology of chronic pelvic pain. Bailliere’s best practice & research. Clinical obstetrics & gynaecology. 2000;14(3):403-414.  https://doi.org/10.1053/beog.1999.0083
  5. Park SJ, Lim JW, Ko YT, Lee DH, Yoon Y, Oh JH, Lee HK, Huh CY. Diagnosis of pelvic congestion syndrome using transabdominal and transvaginal sonography. American journal of roentgenology. 2004;182(3):683-688.  https://doi.org/10.2214/ajr.182.3.1820683
  6. O’Brien MT, Gillespie DL. Diagnosis and treatment of the pelvic congestion syndrome. J Vasc Surg Venous Lymphat Disord. 2015;3(1):96-106.  https://doi.org/10.1016/j.jvsv.2014.05.007
  7. Hansrani V, Morris J, Caress AL, Payne K, Seif M, McCollum CN. Is pelvic vein incompetence associated with symptoms of chronic pelvic pain in women? A pilot study. European journal of obstetrics, gynecology, and reproductive biology. 2016;196:21-25.  https://doi.org/10.1016/j.ejogrb.2015.10.023
  8. Ignacio EA, Dua R, Sarin S, Harper AS, Yim D, Mathur V, Venbrux AC. Pelvic congestion syndrome: diagnosis and treatment. Seminars in interventional radiology. 2008;25(4):361-368.  https://doi.org/10.1055/s-0028-1102998
  9. Pain terms: a list with definitions and notes on usage. Recommended by the IASP Subcommittee on Taxonomy. Pain. 1979;6(3):249. 
  10. Stenyaeva N.N., Apolixina I.A. Xronicheskaya tazovaya bol’: psixosomaticheskie aspekty. Consilium Medicum. 2012;14(6):19-20. (In Russ.).
  11. Eklof B, Perrin M, Delis KT, Rutherford RB, Gloviczki P; American Venous Forum; European Venous Forum; International Union of Phlebology; American College of Phlebology; International Union of Angiology. Updated terminology of chronic venous disorders: the VEIN-TERM transatlantic interdisciplinary consensus document. J Vasc Surg. 2009;49(2):498-501.  https://doi.org/10.1016/j.jvs.2008.09.014
  12. Fomina EE, Akhmetzyanov RV, Bredikhin RA, Tukhbatullin MG. A current view on the problem of varicose veins of the pelvis (review). Sovremennye tehnologii v medicine. 2018;10(2):166-174.  https://doi.org/10.17691/stm2018.10.2.20
  13. Khilnani NM, Meissner MH, Learman LA, Gibson KD, Daniels JP, Winokur RS, et al. Research Priorities in Pelvic Venous Disorders in Women: Recommendations from a Multidisciplinary Research Consensus Panel. Journal of vascular and interventional radiology: JVIR. 2019;30(6):781-789.  https://doi.org/10.1016/j.jvir.2018.10.008
  14. Ctojko YuM, Kirienko AI, Zatevahin II, Pokrovskij AV, Karpenko AA, Zolotuhin IA, Sapelkin SV, Ilyuhin EA, Gavrilov SG, Porembskaya OYa, Borsuk DA, Seliverstov EI, Aluhanyan OA, Andriyashkin AV, Andriyashkin VV, Barinov VE, Belencov SM, Bogdanec LI, Bredihin RA, Bukina OV, Burleva EP, Vahitov MSh, Vinogradov LA, Volkov AYu, Golovanova OV, Guzhkov ON, Ivanov EV, Katel’nickaya OV, Katorkin SE, Kleckin AE, Koshevoj AP, Krylov AYu, Kudykin MN, Kuzovlev SP, Laberko LA, Larin SI, Lishov DE, Lobastov KV, Mazajshvili KV, Markin SM, Parikov MA, Pelevin AV, Potapov MP, Pryadko SI, Rapovka VG, Sabel’nikov VV, Slavin DA, Sokolov AL, Soldatskij EYu, Son’kin IN, Starodubcev VN, Subbotin YuG, Suchkov IA, Sushkov SA, Tolstihin VYu, Fokin AA, Hitar’yan AG, Hodkevich MB, Horev NG, Cukanov YuT, Chabbarov RG, Chernookov AN, Chechetka DYu, Shevela AI, Shimanko AI, Shonov OA, Yashkin MN, Bogachev VYu, Bubnova NA, Dibirov MD, Zhukov BN, Kalinin RE, Katel’nickij II, Plechev VV, Shajdakov EV, Shulutko AM. Rossijskie klinicheskie rekomendacii po diagnostike i lecheniyu hronicheskih zabolevanij ven. Flebologiya. 2018;12(3):146-240. (In Russ.). https://doi.org/10.17116/flebo20187031146
  15. Liddle AD, Davies AH. Pelvic congestion syndrome: chronic pelvic pain caused by ovarian and internal iliac varices. Phlebology. 2007;22(3):100-104.  https://doi.org/10.1258/026835507780807248
  16. Phillips D, Deipolyi AR, Hesketh RL, Midia M, Oklu R. Pelvic congestion syndrome: etiology of pain, diagnosis, and clinical management. J Vasc Interv Radiol. 2014;25(5):725-733. 
  17. Nazarov IP. Patofiziologiya bolevyh sindromov, principy lecheniya (Sobshchenie 1). Sibirskoe medicinskoe obozrenie. 2006;4(41):102-107. (In Russ.).
  18. Gavrilov SG, Balashov AV, Yanina AM, Kamchatnov PR. Mechanisms of the formation of chronic pelvic pain in venous plethora. Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. 2013;113(2):71-75. (In Russ.).
  19. Arndt JO, Klement W. Pain evoked by polymodal stimulation of hand veins in humans. The Journal of physiology. 1991;440:467-478.  https://doi.org/10.1113/jphysiol.1991.sp018719
  20. Shekoyan AO, Bogachev VYu. Venous pain: pathophysiology and treatment principles. Flebolimfologiya. 2010;(36):2-7. (In Russ.).
  21. Kukushkin ML, Tabeeva GR, Podchufarova EV, Yahno NN. Bolevoj sindrom: patofiziologiya, klinika, lechenie. M.: Izdatel’stvo IMA-PRESS; 2011. (In Russ.).
  22. Perry CP. Current concepts of pelvic congestion and chronic pelvic pain. JSLS: Journal of the Society of Laparoendoscopic Surgeons. 2001;5(2):105-110. 
  23. Danziger N. Pathophysiology of pain in venous disease. Phlebolymphology. 2008;15:107-114. 
  24. Riding DM, Hansrani V, McCollum C. Pelvic vein incompetence: clinical perspectives. Vascular health and risk management. 2017;13:439-447.  https://doi.org/10.2147/VHRM.S132827
  25. Hurst DR, Forauer AR, Bloom JR, Greenfield LJ, Wakefield TW, Williams DM. Diagnosis and endovascular treatment of iliocaval compression syndrome. Journal of vascular surgery. 2001;34(1):106-113.  https://doi.org/10.1067/mva.2001.114213
  26. Shadrina AS, Zolotuhin IA, Filipenko ML. Molecular mechanisms of the development of varicose veins of the lower extremities. Flebologiya. 2017;11(2):71-75. (In Russ.). https://doi.org/10.17116/flebo201711271-75
  27. Pocock ES, Alsaigh T, Mazor R, Schmid-Schonbein GW. Cellular and molecular basis of Venous insufficiency. Vasc Cell. 2014;6:24.  https://doi.org/10.1186/s13221-014-0024-5
  28. Dos Santos SJ, Holdstock JM, Harrison CC, Lopez AJ, Whiteley MS. Ovarian Vein Diameter Cannot Be Used as an Indicator of Ovarian Venous Reflux. Eur J Vasc Endovasc Surg. 2015;49(1):90-94.  https://doi.org/10.1016/j.ejvs.2014.10.013
  29. Gavrilov SG, Moskalenko EP, Karalkin AV, Lebedev IS, Son DA, Turishcheva OO. Is the diameter of the pelvic veins a predictor of pelvic venous congestion? Flebologiya. 2017;11(1):28-31. (In Russ.). https://doi.org/10.17116/flebo201711128-31
  30. Dormandy JA. Influence of blood cells and blood flow on venous endothelium. International angiology: a journal of the International Union of Angiology. 1996;15(2):119-123. 
  31. Stones RW. Chronic pain in women: New perspectives on pathophysiology and management. Reproductive Medicine Review. 2000;8(3):229-240.  https://doi.org/10.1017/S096227990000034X
  32. Shevchenko YuL, Stojko YuM, Mazajshvili KV. Lazernaya hirurgiya varikoznoj bolezni. M. 2010. (In Russ.).
  33. Stones RW, Loesch A, Beard RW, Burnstock G. Substance P: endothelial localization and pharmacology in the human ovarian vein. Obstetrics and gynecology. 1995;85(2):273-278.  https://doi.org/10.1016/0029-7844(94)00368-N
  34. Payan DG. Neuropeptides and inflammation: the role of substance P. Annual review of medicine. 1989;40:341-352.  https://doi.org/10.1146/annurev.me.40.020189.002013
  35. Ma Y, Wang ZL, Sun ZX, Men B, Shen BQ. Common TCM syndrome pattern of chronic pelvic pain syndrome relates to plasma substance p and beta endorphin. National journal of andrology. 2014;20(4):363-366. 
  36. Kee Z, Kodji X, Brain SD. The Role of Calcitonin Gene Related Peptide (CGRP) in Neurogenic Vasodilation and Its Cardioprotective Effects. Frontiers in physiology. 2018;9:1249. https://doi.org/10.3389/fphys.2018.01249
  37. Gavrilov SG, Vasilieva GY, Vasiliev IM, Efremova OI. Calcitonin Gene-Related Peptide and Substance P as Predictors of Venous Pelvic Pain. Actanaturae. 2019;11(4):88-92.  https://doi.org/10.32607/20758251-2019-11-4-88-92
  38. Ahmetzyanov RV, Bredihin RA, Fomina EE. Assessment of the quality of life in patients with varicose pelvic disease. Flebologiya. 2019;13(2):133-140. (In Russ.). https://doi.org/10.17116/flebo201913021133
  39. Anisimova EN, Zoryan EV, Dzgoeva OV. Analysis of modern methods for assessing nociceptive pain and the effectiveness of pain relief. Rossijskaya stomatologiya. 2012;5(4):65-69. (In Russ.).
  40. Breivik H, Borchgrevink PC, Allen SM, Rosseland LA, Romundstad L, Hals EK, Kvarstein G, Stubhaug A. Assessment of pain. British journal of anaesthesia. 2008;101(1):17-24.  https://doi.org/10.1093/bja/aen103
  41. Byval’cev VA, Belyh EG, Sorokovnikov VA, Arsent’eva NI. Use of scales and questionnaires in vertebrology. Zhurnal nevrologii i psihiatrii. 2011;9(2):51-56. (In Russ.).
  42. Cleeland CS, Ryan KM. Pain assessment: global use of the Brief Pain Inventory. Annals of the Academy of Medicine, Singapore. 1994;23(2):129-138. 
  43. Melzack R. The McGill Pain Questionnaire: major properties and scoring methods. Pain. 1975;1(3):277-299.  https://doi.org/10.1016/0304-3959(75)90044-5
  44. Harchenko YuA. Adequate pain assessment is the key to its successful treatment. Medicina i farmakologiya. 2014;4(5):4. (In Russ.).
  45. Gavrilov SG, Lebedev IS, Son DA, Turishcheva OO. Von Korff questionnaire in assessment of social disadaptation and therapeutic results in women with pelvic varicose veins. Angiologiya i sosudistaya hirurgiya. 2017;23(1):97-101. (In Russ.).
  46. Gloviczki P, Comerota AJ, Dalsing MC, Eklof BG, Gillespie DL, Gloviczki ML, Lohr JM, McLafferty RB, Meissner MH, Murad MH, Padberg FT, Pappas PJ, Passman MA, Raffetto JD, Vasquez MA, Wakefield TW; Society for Vascular Surgery; American Venous Forum. The care of patients with varicose veins and associated chronic venous diseases: clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum. Journal of vascular surgery. 2011;53(5 suppl):2-48.  https://doi.org/10.1016/j.jvs.2011.01.079
  47. Thors A, Haurani MJ, Gregio TK, Go MR. Endovascular intervention for pelvic congestion syndrome is justified for chronic pelvic pain relief and patient satisfaction. Journal of vascular surgery. Venous and lymphatic disorders. 2014;2(3):268-273.  https://doi.org/10.1016/j.jvsv.2013.12.002
  48. Ahmetzyanov RV, Bredihin RA, Fomina EE, Ignat’ev IM. Method of determining disease severity in women with pelvic varicose veins. Antiologiya i sosudistaya hirurgiya. 2019;25(3):79-87. (In Russ.). https://doi.org/10.33529/ANGIO2019306
  49. Kucher AN. Nejrogennoe vospalenie: bioximicheskie markery’, geneticheskij kontrol’ i bolezni. Byulleten’ sibirskoj mediciny’. 2020;19(2):171-181. (In Russ.). https://doi.org/10.20538/1682-0363-2020-2-171-181
  50. Stones RW, Thomas DC, Beard RW. Suprasensitivity to calcitonin gene-related peptide but not vasoactive intestinal peptide in women with chronic pelvic pain. Clinical autonomic research: official journal of the Clinical Autonomic Research Society. 1992;2(5):343-348.  https://doi.org/10.1007/BF01824305
  51. Dubenko OE. Calcitonin-gene-linked peptide in migraine: pathogenetic factor and therapeutic target. Mezhdunarodnyj nevrologicheskij zhurnal. 2018;2:38-42. (In Russ.).
  52. Whiteley MS, Dos Santos SJ, Harrison CC, Holdstock JM, Lopez AJ. Transvaginal duplex ultrasonography appears to be the gold standard investigation for the haemodynamic evaluation of pelvic venous reflux in the ovarian and internal iliac veins in women. Phlebology. 2015;30(10):706-713.  https://doi.org/10.1177/0268355514554638
  53. White AM, Holdstock JM. Ultrasound assessment of pelvic venousreflux. Indian J Vasc Endovasc Surg. 2018;5:234-243. 
  54. Tsukanov A, Levdanskiy E, Tsukanov Y. Secondary varicose small pelvic veins and their treatment with micronized purified flavonoid fraction. International Journal of Angiology. 2015;25(2):121-127.  https://doi.org/10.1055/s-0035-1570118
  55. Gavrilov SG, Turishcheva OO. Conservative treatment of pelvic varicose veins: indications for and possibilities of therapy. Angiologiya i sosudistaya hirurgiya. 2016;22(3):98-103. (In Russ.).
  56. Gavrilov SG, Moskalenko EP, Karalkin AV. Effectiveness and safety of micronized purified flavonoid fraction for the treatment of concomitant varicose veins of the pelvis and lower extremities. Flebologiya. 2018;12(3):109-117. (In Russ.). https://doi.org/10.17116/flebo2018123109
  57. Simsek M, Burak F, Taskin O. Effects of micronized purified flavonoid fraction (Daflon) on pelvic pain in women with laparoscopically diagnosed pelvic congestion syndrome: a randomized crossover trial. Clinical and experimental obstetrics & gynecology. 2007;34(2):96-98. 
  58. Soysal ME, Soysal S, Vicdan K, Ozer S. A randomized controlled trial of goserelin and medroxyprogesterone acetate in the treatment of pelvic congestion. Human reproduction. 2001;16(5):931-939.  https://doi.org/10.1093/humrep/16.5.931
  59. Shokeir T, Amr M, Abdelshaheed M. The efficacy of Implanon for the treatment of chronic pelvic pain associated with pelvic congestion: 1-year randomized controlled pilot study. Archives of gynecology and obstetrics. 2009;280(3):437-443.  https://doi.org/10.1007/s00404-009-0951-1
  60. Sator-Katzenschlager SM, Scharbert G, Kress HG, Frickey N, Ellend A, Gleiss A, Kozek-Langenecker SA. Chronic pelvic pain treated with gabapentin and amitriptyline: a randomized controlled pilot study. Wiener klinische Wochenschrift. 2005:117(21-22):761-768.  https://doi.org/10.1007/s00508-005-0464-2
  61. Turishcheva OO, Belyaeva ES, Moskalenko EP, Gavrilov SG. Compression treatment of pelvic congestion syndrome. Annaly hirurgii. 2015;6:20-24. (In Russ.).
  62. Gavrilov SG, Kirienko AI, Revyakin VI, Kapranov SA, Karalkin AV. Principy hirurgicheskogo lecheniya varikoznoj bolezni ven taza. Vestnik Rossijskogo gosudarstvennogo medicinskogo universiteta. 2009;5:11-15. (In Russ.).
  63. Hobbs JT. Varicose veins arising from the pelvis due to ovarian vein incompetence. International journal of clinical practice. 2005;59(10):1195-1203. https://doi.org/10.1111/j.1368-5031.2005.00631.x
  64. Gargiulo T, Mais V, Brokaj L, Cossu E, Melis G. Bilateral laparoscopic transperitoneal ligation of ovarian veins for treatment of pelvic congestion syndrome. The Journal of the American Association of Gynecologic Laparoscopists. 2003;10(4):501-504.  https://doi.org/10.1016/s1074-3804(05)60156-9
  65. Kim HS, Malhotra AD, Rowe PC, Lee JM, Venbrux AC. Embolotherapy for pelvic congestion syndrome: long-term results. Journal of vascular and interventional radiology. 2006;17(2 Pt 1):289-297.  https://doi.org/10.1097/01.RVI.0000194870.11980.F8
  66. Kirienko AI, Gavrilov SG, Yanina AM, Turishheva OO. Ocenka effektivnosti hirurgicheskih sposobov lecheniya tazovogo venoznogo polnokroviya. Flebologiya. 2016;10(1):44-49. (In Russ.). https://doi.org/10.17116/flebo201610144-49
  67. Laborda A, Medrano J, de Blas I, Urtiaga I, Carnevale FC, de Gregorio MA. Endovascular treatment of pelvic congestion syndrome: visual analog scale (VAS) long-term follow-up clinical evaluation in 202 patients. Cardiovasc Intervent Radiol. 2013;36(4):1006-1014.
  68. Pyra K, Woźniak S, Drelich-Zbroja A, Wolski A, Jargiełło T. Evaluation of Effectiveness of Embolization in Pelvic Congestion Syndrome with the New Vascular Occlusion Device (ArtVentive EOS): Preliminary Results. Cardiovascular and interventional radiology. 2016;39(8):1122-1127. https://doi.org/10.1007/s00270-016-1380-8
  69. Thors A, Haurani MJ, Gregio TK, Go MR. Endovascular intervention for pelvic congestion syndrome is justified for chronic pelvic pain relief and patient satisfaction. Journal of vascular surgery. Venous and lymphatic disorders. 2014;2(3):268-273.  https://doi.org/10.1016/j.jvsv.2013.12.002
  70. Guirola JA, Sánchez-Ballestin M, Sierre S, Lahuerta C, Mayoral V, De Gregorio MA. A Randomized Trial of Endovascular Embolization Treatment in Pelvic Congestion Syndrome: Fibered Platinum Coils versus Vascular Plugs with 1-Year Clinical Outcomes. Journal of vascular and interventional radiology. 2018;29(1):45-53.  https://doi.org/10.1016/j.jvir.2017.09.011
  71. Dos Santos SJ, Holdstock JM, Harrison CC, Whiteley MS. Long-term results of transjugular coil embolisation for pelvic vein reflux — Results of the abolition of venous reflux at 6—8 years. Phlebology: The Journal of Venous Disease. 2016;31(7):456-462.  https://doi.org/10.1177/0268355515591306
  72. Scultetus AH, Villavicencio JL, Gillespie DL, Kao TC, Rich NM. The pelvic venous syndromes: analysis of our experience with 57 patients. Journal of vascular surgery. 2002;36(5):881-888.  https://doi.org/10.1067/mva.2002.129114
  73. https://doi.org/10.17116/flebo202014031175 
  74. Traber J, Jeanneret-Gris C. Pelvines Stauungssyndrom der Frau — ein Überblick. Gefäßmedizin Scan. 2018;05(01):49-62.  https://doi.org/10.1055/a-0541-2905

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.