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Kornoukhova L.A.

North-Western Centre of Evidence-based Medicine Co., Saint Petersburg, Russia;
Federal State Budgetary Educational Institution of Higher Education «Academician I.P. Pavlov First Saint Petersburg State Medical University» of the Ministry of Healthcare of the Russia, Saint Petersburg, Russia

Emanuel’ V.L.

Federal State Budgetary Educational Institution of Higher Education «Academician I.P. Pavlov First Saint Petersburg State Medical University» of the Ministry of Healthcare of the Russia, Saint Petersburg, Russia

Denisov N.L.

N.I.Pirogov Clinic of High Medical Technologies of the Saint-Petersburg State University

Laboratory predictors of metabolic liver dysfunction in obesity (in Russian only)

Authors:

Kornoukhova L.A., Emanuel’ V.L., Denisov N.L.

More about the authors

Journal: Russian Journal of Evidence-Based Gastroenterology. 2019;8(1): 16‑22

DOI: 10.17116/dokgastro2019801116

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Table of contents

LABORATORY PREDICTORS OF METABOLIC LIVER DYSFUNCTION IN OBESITY (IN RUSSIAN ONLY)
LABORATORY PREDICTORS OF METABOLIC LIVER DYSFUNCTION IN OBESITY (IN RUSSIAN ONLY)

To cite this article:

Kornoukhova LA, Emanuel’ VL, Denisov NL. Laboratory predictors of metabolic liver dysfunction in obesity (in Russian only). Russian Journal of Evidence-Based Gastroenterology. 2019;8(1):16‑22. (In Russ., In Engl.)
https://doi.org/10.17116/dokgastro2019801116

Подписка 2025-2 (Russian Journal of Evidence-Based Gastroenterology)
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Aim — to create a set of laboratory predictors of liver steatosis in abdominal obesity (AO). Material and methods. There were 108 clinically healthy patients aged 18—68 years who were divided into two groups: group 1 included 23 people with metabolically «healthy» obesity, group 2 — 85 patients with metabolically unhealthy phenotype of AO. Patients with clinical signs of liver disease, complications of atherosclerosis and hypertension were excluded. Results. It was revealed the predictor of liver steatosis with a lesion of more than 32% of hepatocytes (LS32) with a threshold value of 0.69 (sensitivity 81%, specificity 88%; p<0.001). Area under ROC-curve was 0.910 (95% CI 0.837—0.958). Conclusion. The results of the study confirm the predictability of laboratory parameters even among patients with metabolically «healthy» phenotype of AO.

Keywords:

abdominal obesity
non-alcoholic fatty liver disease (NAFLD)
preventive medicine
metabolically healthy obesity

Authors:

Kornoukhova L.A.

North-Western Centre of Evidence-based Medicine Co., Saint Petersburg, Russia;
Federal State Budgetary Educational Institution of Higher Education «Academician I.P. Pavlov First Saint Petersburg State Medical University» of the Ministry of Healthcare of the Russia, Saint Petersburg, Russia

Emanuel’ V.L.

Federal State Budgetary Educational Institution of Higher Education «Academician I.P. Pavlov First Saint Petersburg State Medical University» of the Ministry of Healthcare of the Russia, Saint Petersburg, Russia

Denisov N.L.

N.I.Pirogov Clinic of High Medical Technologies of the Saint-Petersburg State University

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