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Eremkina A.K.
National Medical Research Center for Endocrinology, Ministry of Health of Russia, Moscow, Russia
Dzeranova L.K.
ndokrinologicheskiĭ nauchnyĭ tsentr Minzdrava RF, Moskva
Pigarova E.K.
National Medical Research Center for Endocrinology, Ministry of Health of Russia, Moscow, Russia
Mokrysheva N.G.
Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva
Dedov I.I.
Endocrinology Research Centre
Morphofunctional features of non-functioning pituitary adenomas
Journal: Russian Journal of Archive of Pathology. 2019;81(1): 71‑78
Read: 6140 times
To cite this article:
Eremkina AK, Dzeranova LK, Pigarova EK, Mokrysheva NG, Dedov II. Morphofunctional features of non-functioning pituitary adenomas. Russian Journal of Archive of Pathology.
2019;81(1):71‑78. (In Russ.)
https://doi.org/10.17116/patol20198101171
Non-functioning pituitary adenomas (NFPAs) account for about 30% of all pituitary tumors. NFPAs are characterized by the lack of secretory potential or its weak expression insufficient for determination of the blood level of adenohypophyseal tropic hormones and for development of a specific clinical picture. Morphologically, NFPAs are a heterogeneous group of tumors, the classification of which was previously based only on immunoreactivity for pituitary tropic hormones. The WHO revised its Classification of Tumors of Endocrine Organs (4th edition) in 2017. The main changes relate to adenohypophysial-cell lineage for the designation of adenomas into subtypes. The introduction of transcription factor antibodies has become a fundamentally new approach to the classification of NFPAs, which is necessary to recognize less differentiated tumor types. This paper provides information on the new histopathological classification of pituitary adenomas, on the theories of silent adenomas, and on the proliferative and prognostic markers of NFPAs.
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Authors:
Eremkina A.K.
National Medical Research Center for Endocrinology, Ministry of Health of Russia, Moscow, Russia
Dzeranova L.K.
ndokrinologicheskiĭ nauchnyĭ tsentr Minzdrava RF, Moskva
Pigarova E.K.
National Medical Research Center for Endocrinology, Ministry of Health of Russia, Moscow, Russia
Mokrysheva N.G.
Éndokrinologicheskiĭ nauchnyĭ tsentr, Moskva
Dedov I.I.
Endocrinology Research Centre
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