Аутоиммунный/воспалительный синдром, ассоциированный с адъювантами

Авторы:
  • С. Г. Раденска-Лоповок
    ФГАОУ ВО «Первый Московский государственный университет им. И.М. Сеченова» Минздрава России, Москва, Россия; ФГБОУ ДПО Российская медицинская академия непрерывного профессионального образования Минздрава России, Москва, Россия
  • П. Волкова
    Российский национальный исследовательский медицинский университет им. Н.И. Пирогова, Москва, Россия
Журнал: Архив патологии. 2018;80(5): 56-62
Просмотрено: 1866 Скачано: 24
Развитие аутоиммунного/воспалительного синдрома, вызванного адъювантами (ASIA — Autoimmune/Inflammatory Syndrome Induced by Adjuvants), связано с гиперергической реакцией иммунной системы человека. Развитию аутоиммунного воспаления предшествует контакт с внутренними или внешними триггерными факторами (адъювантами) нарушения иммунитета. ASIA ассоциируется с индивидуальной генетической предрасположенностью, вероятно, связанной с носительством HLA-DRB1*01 или HLA-DRB4. Представлены 5 возможных вариантов воздействия адъювантов в патогенезе аутоиммунных нарушений. Приведены диагностические критерии синдрома, а также его клинические, лабораторные и морфологические проявления. Подчеркивается значимость морфологических изменений в диагностике аутоиммунных нарушений. Спектр морфологических изменений при ASIA обширен. В тканях присутствуют признаки иммунного воспаления — лимфогистиоцитарная инфильтрация, гранулематозное воспаление, склеродермоподобные изменения. Характерной особенностью является регрессия клинических, лабораторных и морфологических проявлений после удаления адъюванта.
Ключевые слова:
  • ASIA
  • аутоиммунный синдром
  • адъюванты
  • аутоиммунные болезни

КАК ЦИТИРОВАТЬ:

Раденска-Лоповок С.Г., Волкова П. Аутоиммунный/воспалительный синдром, ассоциированный с адъювантами. Архив патологии. 2018;80(5):56-62. https://doi.org/10.17116/patol20188005156

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