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Matsko D.E.

Zrelov A.A.

Polenov’s neurosurgery institute — the branch of V.A. Almazov National Medical Research Centre, Saint-Petersburg, Russia;
North-Western State Medical University n. a. I.I. Mechnikov, Saint-Petersburg, Russia

Ulitin A.Yu.

Polenov Neurosurgical Institute, a branch of the Almazov National Medical Research Centre under the Ministry of Health of the Russia 12 Mayakovsky str., Saint Petersburg, Russia, 191014

Matsko M.V.

Polenov’s neurosurgery institute — the branch of V.A. Almazov National Medical Research Centre, Saint-Petersburg, Russia;
Saint-Petersburg Clinical Research Center Specialized Types of Medical Care, Saint-Petersburg, Russia;
Saint-Petersburg State University, Saint-Petersburg, Russia;
Saint-Petersburg Medico-Social Institute, Saint-Petersburg, Russia

Skliar S.S.

Polenov’s neurosurgery institute — the branch of V.A. Almazov National Medical Research Centre, Saint-Petersburg, Russia

Baksheeva A.O.

Polenov’s neurosurgery institute — the branch of V.A. Almazov National Medical Research Centre, Saint-Petersburg, Russia;
North-Western State Medical University n. a. I.I. Mechnikov, Saint-Petersburg, Russia

Imianitov E.N.

NII onkologii im. N.N. Petrova, Sankt-Peterburg

Gemistocytic astrocytomas

Authors:

Matsko D.E., Zrelov A.A., Ulitin A.Yu., Matsko M.V., Skliar S.S., Baksheeva A.O., Imianitov E.N.

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Journal: Russian Journal of Archive of Pathology. 2018;80(4): 27‑38

DOI: 10.17116/patol201880427

Views: 4546

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To cite this article:

Matsko DE, Zrelov AA, Ulitin AYu, Matsko MV, Skliar SS, Baksheeva AO, Imianitov EN. Gemistocytic astrocytomas. Russian Journal of Archive of Pathology. 2018;80(4):27‑38. (In Russ.)
https://doi.org/10.17116/patol201880427

Подписка 2025 (Russian Journal of Archive of Pathology)
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Gemistocytic astrocytomas (GA) are a variant of diffuse astrocytomas GII (WHO, 2016). Like all diffuse astrocytomas, GA recur with time, which is often accompanied by malignant degeneretion into the anaplastic astrocytoma GIII or to the secondary glioblastoma GIV. However, the progression-free survival and overall survival in patients with GA is less than in patients with diffuse astrocytomas. Given that this group of patients, according to the WHO classification (2016), is classified as GII, patients with GA usually do not receive comprehensive treatment. We have conducted a thorough analysis of research on this problem for the period from 1956 to 2017. Differences in the histological pattern, immunohistochemical and molecular-genetic profiles, survival of patients with GA and diffuse astrocytomas GII are shown there. A clinical case of a patient with transformation of a diffuse astrocytoma in GA (GIII) and then into a secondary glioblastoma is presented.

Keywords:

gemistocytic astrocytoma
diffuse astrocytoma
molecular-genetic features

Authors:

Matsko D.E.

Zrelov A.A.

Polenov’s neurosurgery institute — the branch of V.A. Almazov National Medical Research Centre, Saint-Petersburg, Russia;
North-Western State Medical University n. a. I.I. Mechnikov, Saint-Petersburg, Russia

Ulitin A.Yu.

Polenov Neurosurgical Institute, a branch of the Almazov National Medical Research Centre under the Ministry of Health of the Russia 12 Mayakovsky str., Saint Petersburg, Russia, 191014

Matsko M.V.

Polenov’s neurosurgery institute — the branch of V.A. Almazov National Medical Research Centre, Saint-Petersburg, Russia;
Saint-Petersburg Clinical Research Center Specialized Types of Medical Care, Saint-Petersburg, Russia;
Saint-Petersburg State University, Saint-Petersburg, Russia;
Saint-Petersburg Medico-Social Institute, Saint-Petersburg, Russia

Skliar S.S.

Polenov’s neurosurgery institute — the branch of V.A. Almazov National Medical Research Centre, Saint-Petersburg, Russia

Baksheeva A.O.

Polenov’s neurosurgery institute — the branch of V.A. Almazov National Medical Research Centre, Saint-Petersburg, Russia;
North-Western State Medical University n. a. I.I. Mechnikov, Saint-Petersburg, Russia

Imianitov E.N.

NII onkologii im. N.N. Petrova, Sankt-Peterburg

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