Clinical and morphological characteristics of gastrointestinal stromal tumors

Khalikov D.D.; Akhmetzyanov F.Sh.; Petrov S.V.

doi:https://doi.org/10.17116/patol201779448-55

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Abstract:

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Despite this, GISTS comprise about 2% in the structure of digestive tract cancers. They are usually localized in the stomach; however, they can be found in the small intestine and more rarely in the colon and esophagus. Although approximately 70% of the GISTs consist predominantly of spindle cells; the epithelioid cell tumors represent 20% of cases; there are also mixed variants. This variability in the morphological structure of GISTs complicates their diagnosis.

Keywords:

GIST

gastrointestinal stromal tumors

KIT

PDFGRA

targeted therapy

Authors:

Khalikov D.D.

Kazan State Medical University, Ministry of Health of the Russian Federation, Kazan, Russia;
Republican Clinical Oncology Dispensary, Ministry of Heath of the Republic of Tatarstan, Kazan, Russia

Akhmetzyanov F.Sh.

Kazan State Medical University, Ministry of Health of the Russian Federation, Kazan, Russia;
Republican Clinical Oncology Dispensary, Ministry of Heath of the Republic of Tatarstan, Kazan, Russia;
Volga Branch, N.N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation, Kazan, Russia

Petrov S.V.

North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia, Elizabethan hospital, Saint-Petersburg, Russia

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References:

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