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Protsenko E.V.

Peretiatko L.P.

FGBU "Ivanovskiĭ NII materinstva i detstva im. V.N. Gorodkova" Minzdrava Rossii

Saryeva O.P.

Laboratoriia patomorfologii i lektronnoĭ mikroskopii FGBU "Ivanovskiĭ NII materinstva i detstva im. V.N. Gorodkova" Minzdrava Rossii, Ivanovo

Pathomorphology of the ventricular germinal zone and neocortex in newborn infants with posthemorrhagic hydrocephalus

Authors:

Protsenko E.V., Peretiatko L.P., Saryeva O.P.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2017;79(2): 36‑40

DOI: 10.17116/patol201779236-40

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To cite this article:

Protsenko EV, Peretiatko LP, Saryeva OP. Pathomorphology of the ventricular germinal zone and neocortex in newborn infants with posthemorrhagic hydrocephalus. Russian Journal of Archive of Pathology. 2017;79(2):36‑40. (In Russ.)
https://doi.org/10.17116/patol201779236-40

Подписка 2025 (Russian Journal of Archive of Pathology)
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Objective. Тo study the morphological features of the ventricular germinal zone and neocortex in newborns at 22—40 weeks’ gestation with posthemorrhagic hydrocephalus. Material and methods. The brains of fetuses and newborns at 22—40 weeks’ gestation with posthemorrhagic hydrocephalus (n=12) were examined; a control group included the brains with a lateral ventricle lumen width of not more than 0.5 cm (n=30). The investigators conducted a comprehensive pathomorphological study of the ventricular germinal zone and neocortex in the projection field No. 6. Results. Posthemorrhagic hydrocephalus is characterized by a deceleration in the reduction of the ventricular germinal zone and by the corresponding level of differentiation of the cortex and neurons to gestational age in the presence of the physiological expression of reelin in the Cajal-Retzius neurons and in that of the impaired expression of matrix metalloproteinase 9 (a decrease) and the glial protein S-100 (an increase) in the cells of the ventricular germinal zone. Conclusion. The morphological features of the ventricular germinal zone and neocortex of fetuses and newborns at 22—40 weeks’ gestation with posthemorrhagic hydrocephalus should be considered as morphological differential diagnostic criteria for the disease.

Keywords:

ventricular germinal zone
neocortex
posthemorrhagic hydrocephalus
newborns

Authors:

Protsenko E.V.

Peretiatko L.P.

FGBU "Ivanovskiĭ NII materinstva i detstva im. V.N. Gorodkova" Minzdrava Rossii

Saryeva O.P.

Laboratoriia patomorfologii i lektronnoĭ mikroskopii FGBU "Ivanovskiĭ NII materinstva i detstva im. V.N. Gorodkova" Minzdrava Rossii, Ivanovo

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  4. Harris CA, McAllister JP. What we should know about the cellular and tissue response causing catheter obstruction in the treatment of hydrocephalus. Neurosurgery. 2012;70(6):1589-1602. doi:10.1227/neu.0b013e318244695f
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  12. Lockwood C, Oner C, Uz Y, Kayisli U, Huang S, Buchwalder L et al. Matrix metalloproteinase 9 (MMP 9) expression in preeclamptic decidua and MMP 9 induction by tumor necrosis factor alpha and interleukin 1 beta in human first trimester desidual cells. Biol Reprod. 2008;78(6):1064-1072. doi:10.1095/biolreprod.107.063743
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