Activity of proliferative and apoptotic processes in the integration of human papillomavirus type 16 DNA into the cervical epithelium

Ershov V.A.

SPb GUZ "Gorodskoĭ klinicheskiĭ onkologicheskiĭ dispanser"

Chirsky V.S.

S.M. Kirov Military Medical Academy, Saint Petersburg

Viazovaia A.A.

FGUN "Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut épidemiologii i mikrobiologii im. Pastera" Rospotrebnadzora

Narvskaia O.V.

FGUN "Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut épidemiologii i mikrobiologii im. Pastera" Rospotrebnadzora

Lisianskaia A.S.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova

Activity of proliferative and apoptotic processes in the integration of human papillomavirus type 16 DNA into the cervical epithelium

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Ershov V.A., Chirsky V.S., Viazovaia A.A., Narvskaia O.V., Lisianskaia A.S.

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Journal: Russian Journal of Archive of Pathology. 2013;75(2): 16‑19

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Ershov VA, Chirsky VS, Viazovaia AA, Narvskaia OV, Lisianskaia AS. Activity of proliferative and apoptotic processes in the integration of human papillomavirus type 16 DNA into the cervical epithelium. Russian Journal of Archive of Pathology. 2013;75(2):16‑19. (In Russ.)

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Sixty 60 human papillomavirus (HPV) type 16-positive cervical epithelium biopsy specimens were studied by cytological, histological, immunomorphological, and PCR assays. No correlation was found between proliferation markers and the degree of integration of HPV 16 DNA integration into the cell genome. The number of cells with Ki-67 expression, mitoses, and their alteration was related to the grade of epithelial lesion. Expression of p53 was detected only in the episomal form of HPV DNA and its low integration.

Keywords:

proliferation

apoptosis

cervix uteri

human papillomavirus

Authors:

Ershov V.A.

SPb GUZ "Gorodskoĭ klinicheskiĭ onkologicheskiĭ dispanser"

Chirsky V.S.

S.M. Kirov Military Medical Academy, Saint Petersburg

Viazovaia A.A.

FGUN "Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut épidemiologii i mikrobiologii im. Pastera" Rospotrebnadzora

Narvskaia O.V.

FGUN "Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut épidemiologii i mikrobiologii im. Pastera" Rospotrebnadzora

Lisianskaia A.S.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova

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