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Ershov V.A.

SPb GUZ "Gorodskoĭ klinicheskiĭ onkologicheskiĭ dispanser"

Chirsky V.S.

S.M. Kirov Military Medical Academy, Saint Petersburg

Viazovaia A.A.

FGUN "Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut épidemiologii i mikrobiologii im. Pastera" Rospotrebnadzora

Narvskaia O.V.

FGUN "Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut épidemiologii i mikrobiologii im. Pastera" Rospotrebnadzora

Lisianskaia A.S.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova

Activity of proliferative and apoptotic processes in the integration of human papillomavirus type 16 DNA into the cervical epithelium

Authors:

Ershov V.A., Chirsky V.S., Viazovaia A.A., Narvskaia O.V., Lisianskaia A.S.

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Journal: Russian Journal of Archive of Pathology. 2013;75(2): 16‑19

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Table of contents

ACTIVITY OF PROLIFERATIVE AND APOPTOTIC PROCESSES IN THE INTEGRATION OF HUMAN PAPILLOMAVIRUS TYPE 16 DNA INTO THE CERVICAL EPITHELIUM
ACTIVITY OF PROLIFERATIVE AND APOPTOTIC PROCESSES IN THE INTEGRATION OF HUMAN PAPILLOMAVIRUS TYPE 16 DNA INTO THE CERVICAL EPITHELIUM

To cite this article:

Ershov VA, Chirsky VS, Viazovaia AA, Narvskaia OV, Lisianskaia AS. Activity of proliferative and apoptotic processes in the integration of human papillomavirus type 16 DNA into the cervical epithelium. Russian Journal of Archive of Pathology. 2013;75(2):16‑19. (In Russ.)

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Sixty 60 human papillomavirus (HPV) type 16-positive cervical epithelium biopsy specimens were studied by cytological, histological, immunomorphological, and PCR assays. No correlation was found between proliferation markers and the degree of integration of HPV 16 DNA integration into the cell genome. The number of cells with Ki-67 expression, mitoses, and their alteration was related to the grade of epithelial lesion. Expression of p53 was detected only in the episomal form of HPV DNA and its low integration.

Keywords:

proliferation
apoptosis
cervix uteri
human papillomavirus

Authors:

Ershov V.A.

SPb GUZ "Gorodskoĭ klinicheskiĭ onkologicheskiĭ dispanser"

Chirsky V.S.

S.M. Kirov Military Medical Academy, Saint Petersburg

Viazovaia A.A.

FGUN "Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut épidemiologii i mikrobiologii im. Pastera" Rospotrebnadzora

Narvskaia O.V.

FGUN "Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ institut épidemiologii i mikrobiologii im. Pastera" Rospotrebnadzora

Lisianskaia A.S.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.P. Pavlova

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References:

  1. Pyeon D., Pearce S.M., Lank S.M., Ahlquist P., Lambert P.F. Establishment of human papillomavirus infection requires cell cycle progression. PloS Pathog 2009; 5 (2): e1000318.
  2. Ershov V.A., Narvskaya O.V. Fonovye protsessy i neoplaziya epiteliya sheiki matki. SPb: OOO Chelovek; 2007. 80 s.
  3. Vyazovaya A.A., Kuevda D.A., Trofimova O.B., Ershov V.A., Narvskaya O.V. Integratsiya DNK virusa papillomy cheloveka 16 genotipa v genom kletok tservikal'nogo epiteliya pri fonovykh protsessakh i neoplazii sheiki matki. V kn.: Papillomavirusnaya infektsiya i rak. Integrirovannaya sistema nadzora i profilaktiki: Materialy II simpoziuma s mezhdunarodnym uchastiem. SPb: NIIEM im. Pastera; 2011: 12-4.
  4. Doorbar J. The papillomavirus life cycle. J. Clin. Virol. 2005; 32 (Suppl. 1): 7-15.
  5. Wang H-K., Duffy A.A., Broker T.R., Chow L.T. Robust production and passaging of infectious HPV in sguamous epithelium of primary human keratinocytes. Genes Dev. 2009; 23: 181-94.
  6. Wang X., Meyers C., Guo M., Zheng Z.M. Upregulation of p18Ink4c expression by oncogenic HPV E6 via p53-miR-34a pathway. Int. J. Cancer 2011; 129 (6): 1362-72.
  7. Apgar B.S., Zoschnick L., Wright JR T.C. The 2001 Bethesda system terminology. Am. Fam. Physician. 2003; 68 (15): 1992-8.
  8. Tavassoli F.A., Devilee P., eds. Pathology and genetics of tumours of the breast and female genital organs. WHO classification of tumours. Lyon: IARC Press; 2003. 432 p.
  9. Kuevda D.A., Ermakova N.V., Shipulina O.Yu., Minkina G.N., Kiseleva V.I., Shinkarkina A.P. Vysokaya virusnaya nagruzka i integratsiya VPCh v genom cheloveka kak molekulyarnye markery displasticheskikh izmenenii sheiki matki. V kn.: Pokrovskii V.I., red. Genodiagnostika infektsionnykh boleznei - 2007. t. 3. M: Universitetskaya kniga, Pais; 2007. 430 s.
  10. Andersson S., Safari H., Mints M., Lewensohn-Fuchs I., Gyllensten U., Johansson B. Type distribution, viral load and integration status of high-risk human papillomaviruses in pre-stages of cervical cancer (CIN). Br. J. Cancer 2005; 92: 2195-200.
  11. Jiang M., Baseman J., Koutsky L., Feng Q., Mao C., Kiviat N., Fu L. Sequence variation of Human Papillomavirus type 16 and measurement of viral integration by quantitative PCR. J. Clin. Microbiol. 2009; 47 (3): 521-6.
  12. Danilova N.V., Andreeva Yu.Yu., Mal'kov P.G. Differentsial'nyi diagnoz predrakovykh i regenerativnykh izmenenii v epitelii sheiki matki s primeneniem immunogistokhimicheskogo issledovaniya. Arkhiv patologii 2011; 73 (2): 10-4.
  13. Korolenkova L.I., Stepanova E.V., Ermilova V.D., Baryshnikov A.Yu., Briuzgin V.V. Ekspressiya Ki-67, timidin fosforilazy i PTEN v intraepitelial'noi tservikal'noi kartsinome. Voprosy onkologii 2011; 57 (2): 199-203.
  14. Tan G.C., Sharifah N.A., Shiran M.S., Salwati S., Hatta A.Z., Paul-Ng H.O. Utility of Ki-67 and p53 in distinguishing cervical intraepithelial neoplasia 3 from squamous cell carcinoma of the cervix. Asian Pac. J. Cancer Prev. 2008; 9 (4): 781-4.
  15. Kazantseva I.A. Patologiya mitoza v opukholyakh cheloveka. Novosibirsk: Nauka; 1981. 114 s.
  16. Conesa-Zamora P., Doménech-Peris A., Orantes-Casado F.J., Ortiz-Reina S., Sahuquillo-Frías L., Acosta-Ortega J., García-Solano J., Pérez-Guillermo M. Effect of human papillomavirus on cell cycle-related proteins p16, Ki-67, Cyclin D1, p53, and ProEx C in precursor lesions of cervical carcinoma: a tissue microarray study. Am. J. Clin. Pathol. 2009; 132 (3): 378-90.
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