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Efremova Iu.E.

Laboratoriia molekuliarnoĭ i kletochnoĭ kardiologii i otdel angiologii Rossiĭskogo kardiologicheskogo nauchno-proizvodstvennogo kompleksa Minzdravsotsrazvitiia Rossii

Andreeva E.R.

Laboratoriia molekuliarnoĭ i kletochnoĭ kardiologii i otdel angiologii Rossiĭskogo kardiologicheskogo nauchno-proizvodstvennogo kompleksa Minzdravsotsrazvitiia Rossii

Soboleva G.N.

Laboratoriia molekuliarnoĭ i kletochnoĭ kardiologii i otdel angiologii Rossiĭskogo kardiologicheskogo nauchno-proizvodstvennogo kompleksa Minzdravsotsrazvitiia Rossii

Radiukhina N.V.

Laboratoriia molekuliarnoĭ i kletochnoĭ kardiologii i otdel angiologii Rossiĭskogo kardiologicheskogo nauchno-proizvodstvennogo kompleksa Minzdravsotsrazvitiia Rossii

Beloyartsev D.F.

Vishnevskiy Surgery Institute, Moscow

Karpov Iu.A.

Laboratoriia molekuliarnoĭ i kletochnoĭ kardiologii i otdel angiologii Rossiĭskogo kardiologicheskogo nauchno-proizvodstvennogo kompleksa Minzdravsotsrazvitiia Rossii

Tararak É.M.

Laboratoriia molekuliarnoĭ i kletochnoĭ kardiologii i otdel angiologii Rossiĭskogo kardiologicheskogo nauchno-proizvodstvennogo kompleksa Minzdravsotsrazvitiia Rossii

In vitro accumulation of the photosensitizer Photosens in the atherosclerotic plaque of the human carotid artery

Authors:

Efremova Iu.E., Andreeva E.R., Soboleva G.N., Radiukhina N.V., Beloyartsev D.F., Karpov Iu.A., Tararak É.M.

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Journal: Russian Journal of Archive of Pathology. 2012;74(5): 18‑22

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IN VITRO ACCUMULATION OF THE PHOTOSENSITIZER PHOTOSENS IN THE ATHEROSCLEROTIC PLAQUE OF THE HUMAN CAROTID ARTERY
IN VITRO ACCUMULATION OF THE PHOTOSENSITIZER PHOTOSENS IN THE ATHEROSCLEROTIC PLAQUE OF THE HUMAN CAROTID ARTERY

To cite this article:

Efremova IuE, Andreeva ER, Soboleva GN, Radiukhina NV, Beloyartsev DF, Karpov IuA, Tararak ÉM. In vitro accumulation of the photosensitizer Photosens in the atherosclerotic plaque of the human carotid artery. Russian Journal of Archive of Pathology. 2012;74(5):18‑22. (In Russ.)

Подписка 2025-2 (Russian Journal of Archive of Pathology)
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The investigation was undertaken to study the accumulation of the photosensitizer Photosens in arterial atherosclerotic plaques and to immunohistochemically identify cellular elements in them. Specimens were obtained during carotid endarterectomy. The preferential accumulation of Photosens occurred in the plaque areas containing the largest number of cells, such as macrophages and lymphocytes. The photosensitizer accumulated to a greater extent in the unstable plaques than in the stable ones, which seems to be associated with the more marked infiltration of unstable plaques by the cells involved in the inflammatory reaction.

Keywords:

atherosclerosis
carotid artery
photodynamic reaction

Authors:

Efremova Iu.E.

Laboratoriia molekuliarnoĭ i kletochnoĭ kardiologii i otdel angiologii Rossiĭskogo kardiologicheskogo nauchno-proizvodstvennogo kompleksa Minzdravsotsrazvitiia Rossii

Andreeva E.R.

Laboratoriia molekuliarnoĭ i kletochnoĭ kardiologii i otdel angiologii Rossiĭskogo kardiologicheskogo nauchno-proizvodstvennogo kompleksa Minzdravsotsrazvitiia Rossii

Soboleva G.N.

Laboratoriia molekuliarnoĭ i kletochnoĭ kardiologii i otdel angiologii Rossiĭskogo kardiologicheskogo nauchno-proizvodstvennogo kompleksa Minzdravsotsrazvitiia Rossii

Radiukhina N.V.

Laboratoriia molekuliarnoĭ i kletochnoĭ kardiologii i otdel angiologii Rossiĭskogo kardiologicheskogo nauchno-proizvodstvennogo kompleksa Minzdravsotsrazvitiia Rossii

Beloyartsev D.F.

Vishnevskiy Surgery Institute, Moscow

Karpov Iu.A.

Laboratoriia molekuliarnoĭ i kletochnoĭ kardiologii i otdel angiologii Rossiĭskogo kardiologicheskogo nauchno-proizvodstvennogo kompleksa Minzdravsotsrazvitiia Rossii

Tararak É.M.

Laboratoriia molekuliarnoĭ i kletochnoĭ kardiologii i otdel angiologii Rossiĭskogo kardiologicheskogo nauchno-proizvodstvennogo kompleksa Minzdravsotsrazvitiia Rossii

List of references:

  1. Andreeva E.R., Udartseva O.O., Vozovikov I.N., Kuz'min S.G., Tararak E.M. Izuchenie in vitro fotodinamicheskogo vozdeistviya na vozmozhnye kletki-misheni sosudistoi stenki. Kardiologicheskii vestnik. 2008; 2: 12-6.
  2. Allison B.A., Crespo M.T., Jain A.K., Richter A.M., Hsiang Y.N., Levy J.G. Delivery of benzoporphyrin derivative, a photosensitizer, into atherosclerotic plaque of watanabe heritable hyperlipidemic rabbits and balloon-injured new zealand rabbits. Photochem. Photobiol. 1997; 65 (5): 877-83.
  3. Biały D., Derkacz A., Wawrzyńska M., Bednarkiewicz A., Ziofkowsky P., Nowosad H. et al. In vitro photodynamic diagnosis of atherosclerotic wall changes with the use of mono-l-aspartyl chlorin e6. A preliminary report. Kardiol. Pol. 2003; 59: 293-301.
  4. Casscells W., Naghavi M., Willerson J.T. Mini-review: expert opinions. Vulnerable atherosclerotic plaque a multifocal disease. Circulation. 2003; 107: 2072-5.
  5. Castano A.P., Demidova T.N., Hamblin M.R. Mechanisms in photodynamic therapy: part two: cellular signaling, cell metabolism and modes of cell death. Photodiagn. Photodynam. Ther. 2005; 2: 1-23.
  6. Delettre E., Brault D., Bruneval P., Vever-Bizet C., Dellinger M., Delgado O. et al. In vitro uptake of dicarboxylic porphyrins by human atheroma. Kinetic and analytical studies. Photochem. Photobiol. 1991; 54 (2): 239-46.
  7. Falk E., Shah P.K., Fuster V. Coronary plaque disruption. Circulation. 1995; 92: 657-71.
  8. Gonschior P., Erdemci A., Gerheuser F., Mack B., Gonschior G.-M., Groh J. et al. Fluorescence microscopic and histologic analysis of photosensitizer uptake in human atherosclerotic lesions. Lasers Med. Sci. 1993; 8: 289-95.
  9. Hsiang Y.N., Crespo M.T., Richter A.M., Jain A.K., Fragoso M., Levy J.G. In vitro and in vivo uptake of benzoporphyrin derivative into human and miniswine atherosclerotic plaque. Photochem. Photobiol. 1993; 57 (4): 670-4.
  10. Kwon O.C., Yoon H.J., Kim K.H., Kim H.T., Yoon Y.H., Kim J.K. Fluorescence kinetics of protoporphyrin-IX induced from 5-ALA compounds in rabbit postballoon injury model for ALA-photoangioplasty. Photochem. Photobiol. 2008; 84: 1209-14.
  11. Pollock M.E., Eugene J., Hammer-Wilson M., Berns M.W. Photosensitization of experimental atheromas by porphyrins. J. Am. Coll. Cardiol. 1987; 9: 639-46.
  12. Spears J.R., Serur J., Shropshire D., Paulin S. Fluorescence of experimental atheromatous plaques with hematoporphyrin derivative. J. Clin. Invest. 1983; 71 (2): 395-9.
  13. Spokojny A.M., Serur J.R., Skillman J., Spears J.R. Uptake of hematoporphyrin derivative by atheromatous plaques: studies in human in vitro and rabbit in vivo. J. Am. Coll. Cardiol. 1986; 8: 1387-92.
  14. Stary H.C. Natural history and histological classification of atherosclerotic lesions. Arterioscler. Thromb. Vasc. Biol. 2000; 20: 1177-8.
  15. Virmani R., Kolodgie F.D., Burke A.P., Farb A., Schwartzet S.M. Lessons from sudden coronary death. A comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler. Thromb. Vasc. Biol. 2000; 20: 1262-75.
  16. Waksman R., Pauline E., McEwan P.E., Travis I. M., Pakala R., Kolodgie F.D., Hellinga D.G. PhotoPoint photodynamic therapy promotes stabilization of atherosclerotic plaques and inhibits plaque progression. J. Am. Coll. Cardiol. 2008; 52: 1024-32.
  17. Yamaguchi S., Tsuda H., Takemori M., Nakata S., Nishimura S., Kawamura N. et al. Photodynamic therapy for cervical intraepithelial olneoplasia. Oncogy. 2005; 69: 110-6.

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